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Csf1r colony stimulating factor 1 receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 307403, updated on 27-Nov-2014
Official Symbol
Csf1rprovided by RGD
Official Full Name
colony stimulating factor 1 receptorprovided by RGD
Primary source
RGD:2425
See related
Ensembl:ENSRNOG00000018414
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
c-fms; mrfms; CSF-1R; CSF-1-R; M-CSF-R
Summary
may mediate normal and neoplastic growth of muscular cells [RGD, Feb 2006]
See Csf1r in MapViewer
Location:
18q12.1
Exon count:
26
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (56414493..56458300)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (55662670..55689297)

Chromosome 18 - NC_005117.4Genomic Context describing neighboring genes Neighboring gene caudal type homeo box 1 Neighboring gene uncharacterized LOC102555480 Neighboring gene platelet derived growth factor receptor, beta polypeptide Neighboring gene HMG box domain containing 3 Neighboring gene solute carrier family 26 (anion exchanger), member 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
    Transcriptional misregulation in cancer, organism-specific biosystem
    Transcriptional misregulation in cancer
  • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
    Transcriptional misregulation in cancer, conserved biosystem
    Transcriptional misregulation in cancer

Markers

Homology

Clone Names

  • MGC125014

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cytokine binding IEA
Inferred from Electronic Annotation
more info
 
cytokine binding ISO
Inferred from Sequence Orthology
more info
 
cytokine binding ISS
Inferred from Sequence or Structural Similarity
more info
 
macrophage colony-stimulating factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
macrophage colony-stimulating factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
macrophage colony-stimulating factor receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
molecular_function ND
No biological Data available
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction maintenance IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction maintenance ISO
Inferred from Sequence Orthology
more info
 
cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to cytokine stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to macrophage colony-stimulating factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to macrophage colony-stimulating factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
macrophage colony-stimulating factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
macrophage colony-stimulating factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
macrophage colony-stimulating factor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
osteoclast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol metabolic process ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell motility ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of chemokine secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chemokine secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of Stat3 protein IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of Stat3 protein ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of Stat3 protein ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of actin cytoskeleton reorganization IEA
Inferred from Electronic Annotation
more info
 
regulation of actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
regulation of actin cytoskeleton reorganization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
 
ruffle organization IEA
Inferred from Electronic Annotation
more info
 
ruffle organization ISO
Inferred from Sequence Orthology
more info
 
ruffle organization ISS
Inferred from Sequence or Structural Similarity
more info
 
skeletal muscle tissue development IEP
Inferred from Expression Pattern
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular_component ND
No biological Data available
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex IEA
Inferred from Electronic Annotation
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
macrophage colony-stimulating factor 1 receptor
Names
macrophage colony-stimulating factor 1 receptor
CSF-1 receptor
fms proto-oncogene
proto-oncogene fms
proto-oncogene c-Fms
NP_001025072.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029901.1NP_001025072.1  macrophage colony-stimulating factor 1 receptor precursor

    Status: PROVISIONAL

    Source sequence(s)
    AABR07032246
    Conserved Domains (6) summary
    cd05106
    Location:585957
    PTKc_CSF-1R; Catalytic domain of the Protein Tyrosine Kinase, Colony-Stimulating Factor-1 Receptor
    cd00096
    Location:264336
    Ig; Immunoglobulin domain
    smart00410
    Location:253339
    IG_like; Immunoglobulin like
    pfam07714
    Location:624948
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13895
    Location:64129
    Ig_2; Immunoglobulin domain
    cl11960
    Location:343442
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005117.4 

    Range
    56414493..56458300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772148.1XP_008770370.1  

    See proteins identical to XP_008770370.1

    UniProtKB/TrEMBL
    D4ACA7
    Conserved Domains (7) summary
    cd05106
    Location:541913
    PTKc_CSF-1R; Catalytic domain of the Protein Tyrosine Kinase, Colony-Stimulating Factor-1 Receptor
    cd00096
    Location:220292
    Ig; Immunoglobulin domain
    smart00409
    Location:311395
    IG; Immunoglobulin
    smart00410
    Location:209295
    IG_like; Immunoglobulin like
    pfam07714
    Location:580904
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13895
    Location:2085
    Ig_2; Immunoglobulin domain
    cl11960
    Location:299398
    Ig; Immunoglobulin domain
  2. XM_008772147.1XP_008770369.1  

    See proteins identical to XP_008770369.1

    UniProtKB/TrEMBL
    D4ACA7
    Conserved Domains (7) summary
    cd05106
    Location:541913
    PTKc_CSF-1R; Catalytic domain of the Protein Tyrosine Kinase, Colony-Stimulating Factor-1 Receptor
    cd00096
    Location:220292
    Ig; Immunoglobulin domain
    smart00409
    Location:311395
    IG; Immunoglobulin
    smart00410
    Location:209295
    IG_like; Immunoglobulin like
    pfam07714
    Location:580904
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13895
    Location:2085
    Ig_2; Immunoglobulin domain
    cl11960
    Location:299398
    Ig; Immunoglobulin domain
  3. XM_006254813.2XP_006254875.1  

    See proteins identical to XP_006254875.1

    UniProtKB/TrEMBL
    D4ACA7
    Related
    ENSRNOP00000040411
    Conserved Domains (7) summary
    cd05106
    Location:541913
    PTKc_CSF-1R; Catalytic domain of the Protein Tyrosine Kinase, Colony-Stimulating Factor-1 Receptor
    cd00096
    Location:220292
    Ig; Immunoglobulin domain
    smart00409
    Location:311395
    IG; Immunoglobulin
    smart00410
    Location:209295
    IG_like; Immunoglobulin like
    pfam07714
    Location:580904
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13895
    Location:2085
    Ig_2; Immunoglobulin domain
    cl11960
    Location:299398
    Ig; Immunoglobulin domain

Alternate Rn_Celera

Genomic

  1. AC_000086.1 

    Range
    52716221..52742736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)