Format

Send to:

Choose Destination

HCRT hypocretin (orexin) neuropeptide precursor [ Homo sapiens (human) ]

Gene ID: 3060, updated on 22-May-2016
Official Symbol
HCRTprovided by HGNC
Official Full Name
hypocretin (orexin) neuropeptide precursorprovided by HGNC
Primary source
HGNC:HGNC:4847
See related
Ensembl:ENSG00000161610 HPRD:03836; MIM:602358; Vega:OTTHUMG00000180107
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OX; PPOX; NRCLP1
Summary
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]
Orthologs
Location:
17q21
Exon count:
2
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (42184060..42185452, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40336078..40337470, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RAB5C, member RAS oncogene family Neighboring gene uncharacterized LOC105371781 Neighboring gene potassium voltage-gated channel subfamily H member 4 Neighboring gene GH3 domain containing Neighboring gene signal transducer and activator of transcription 5B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Orexin and neuropeptides FF and QRFP bind to their respective receptors, organism-specific biosystem (from REACTOME)
    Orexin and neuropeptides FF and QRFP bind to their respective receptors, organism-specific biosystemThe orphan G protein-coupled receptors mentioned here regulate sleep and appetite.
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
neuropeptide hormone activity IEA
Inferred from Electronic Annotation
more info
 
type 1 hypocretin receptor binding IEA
Inferred from Electronic Annotation
more info
 
type 2 hypocretin receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
eating behavior IEA
Inferred from Electronic Annotation
more info
 
excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
 
negative regulation of potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transmission of nerve impulse IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
phospholipase C-activating G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transmission of nerve impulse IEA
Inferred from Electronic Annotation
more info
 
protein kinase C-activating G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
postsynapse IEA
Inferred from Electronic Annotation
more info
 
rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
secretory granule IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle TAS
Traceable Author Statement
more info
PubMed 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011448.1 RefSeqGene

    Range
    5001..6393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001524.1NP_001515.1  orexin precursor

    See identical proteins and their annotated locations for NP_001515.1

    Status: REVIEWED

    Source sequence(s)
    AF041240
    Consensus CDS
    CCDS11421.1
    UniProtKB/Swiss-Prot
    O43612
    Related
    ENSP00000293330, OTTHUMP00000263356, ENST00000293330, OTTHUMT00000449792
    Conserved Domains (1) summary
    pfam02072
    Location:1131
    Orexin; Prepro-orexin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    42184060..42185452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    40571806..40573198 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)