U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pla2g4aa phospholipase A2, group IVAa (cytosolic, calcium-dependent) [ Danio rerio (zebrafish) ]

Gene ID: 30554, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
pla2g4aaprovided by ZNC
Official Full Name
phospholipase A2, group IVAa (cytosolic, calcium-dependent)provided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-45
See related
Ensembl:ENSDARG00000024546 AllianceGenome:ZFIN:ZDB-GENE-990415-45
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cpla2; pla2g4; PLA2G4A
Summary
Enables phospholipase activity. Acts upstream of or within inflammatory response to wounding; ovarian follicle development; and regulation of G1/S transition of mitotic cell cycle. Predicted to be located in cytoplasmic vesicle. Predicted to be active in several cellular components, including Golgi apparatus; cytosol; and endoplasmic reticulum. Is expressed in brain; otic vesicle; and ovary. Orthologous to human PLA2G4A (phospholipase A2 group IVA). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See pla2g4aa in Genome Data Viewer
Location:
chromosome: 2
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (20925899..20957362)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (21267837..21299300)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene phosducin a Neighboring gene prostaglandin-endoperoxide synthase 2a Neighboring gene actin related protein 2/3 complex, subunit 5A Neighboring gene LYR motif containing 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Ovulation is associated with the LH-dependent induction of pla2g4aa in zebrafish. Tang H, et al. Mol Cell Endocrinol, 2018 Sep 15. PMID 29326060
  2. Phylogenetic and structural analysis of the phospholipase A2 gene family in vertebrates. Huang Q, et al. Int J Mol Med, 2015 Mar. PMID 25543670, Free PMC Article
  3. The Cell Nucleus Serves as a Mechanotransducer of Tissue Damage-Induced Inflammation. Enyedi B, et al. Cell, 2016 May 19. PMID 27203112, Free PMC Article
  4. Cytosolic phospholipase A2α regulates G1 progression through modulating FOXO1 activity. Naini SM, et al. FASEB J, 2016 Mar. PMID 26644349, Free PMC Article
  5. Tissue Damage Signaling Is a Prerequisite for Protective Neutrophil Recruitment to Microbial Infection in Zebrafish. Huang C, et al. Immunity, 2018 May 15. PMID 29768163, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nuclear progesterone receptor regulates ptger4b and PLA2G4A expression in zebrafish (Danio rerio) ovulation.
    Title: Nuclear progesterone receptor regulates ptger4b and PLA2G4A expression in zebrafish (Danio rerio) ovulation.
  2. these findings suggest that pla2g4aa is related to the ovulation process in zebrafish.
    Title: Ovulation is associated with the LH-dependent induction of pla2g4aa in zebrafish.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysophospholipase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidyl phospholipase B activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycerophospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within inflammatory response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ovarian follicle development IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of G1/S transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cytosolic phospholipase A2
Names
phospholipase A2 group IVA
NP_571370.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131295.2 → NP_571370.1  cytosolic phospholipase A2

    See identical proteins and their annotated locations for NP_571370.1

    Status: PROVISIONAL

    Source sequence(s)
    U10330
    UniProtKB/Swiss-Prot
    P50392
    UniProtKB/TrEMBL
    B3DFL0
    Related
    ENSDARP00000090686.2, ENSDART00000099913.3
    Conserved Domains (3) summary
    cd07200
    Location:138 → 719
    cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cd04036
    Location:13 → 132
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    smart00022
    Location:113 → 658
    PLAc; Cytoplasmic phospholipase A2, catalytic subunit

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    20925899..20957362
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50392.1 GenPept UniProtKB/Swiss-Prot:P50392

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous