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    fgf8a fibroblast growth factor 8a [ Danio rerio ]

    Gene ID: 30538, updated on 20-Apr-2012
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    Summary

    Official Symbol
    fgf8aprovided by ZNC
    Official Full Name
    fibroblast growth factor 8aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-72
    See related
    Ensembl:ENSDARG00000003399; Vega:OTTDARG00000018834
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    ace; fgf8; cb110; fgf-8; id:ibd5031; wu:fb73a06; etID309886.13; MGC101652
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    Genomic context

    Location :
    chromosome: 13
    Sequence :
    Chromosome: 13; NC_007124.5 (28719119..28725587)
    See fgf8a in MapViewer

    Chromosome 13 - NC_007124.5Genomic Context describing neighboring genes Neighboring gene ladybird homeobox 1a Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 15a Neighboring gene F-box and WD-40 domain protein 4 Neighboring gene WW domain binding protein 1-like a

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Conditions that influence the response to Fgf during otic placode induction. Padanad MS, et al. Dev Biol, 2012 Apr 1. PMID 22327005.
    2. Fgf signaling is required for photoreceptor maintenance in the adult zebrafish retina. Hochmann S, et al. PLoS One, 2012. PMID 22291943.
    3. Voltage-gated calcium channel CACNB2 (β2.1) protein is required in the heart for control of cell proliferation and heart tube integrity. Chernyavskaya Y, et al. Dev Dyn, 2012 Apr. PMID 22274990.
    4. HSPG-deficient zebrafish uncovers dental aspect of multiple osteochondromas. Wiweger MI, et al. PLoS One, 2012. PMID 22253766.
    5. Midbrain-hindbrain boundary patterning and morphogenesis are regulated by diverse grainy head-like 2-dependent pathways. Dworkin S, et al. Development, 2012 Feb. PMID 22223680.

    See all (257) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Activation of hs:fgf3 or hs:fgf8 during late blastula/early gastrula stages (5 hpf or earlier) resulted in complete dorsalization of the embryo
      Title: Conditions that influence the response to Fgf during otic placode induction.
    2. Retinoic acid signaling is required shortly after gastrulation in the forelimb field to temper Fgf8a signaling in the cardiac field, thus coordinating the development of the heart and forelimb.
      Title: Restraint of Fgf8 signaling by retinoic acid signaling is required for proper heart and forelimb formation.
    3. show that Pou5f1 binds to phylogenetically conserved Oct/Pou5f1 sites in the vox promoter, both in vivo and in vitro
      Title: Pou5f1 contributes to dorsoventral patterning by positive regulation of vox and modulation of fgf8a expression.
    4. Data show that positive feedback regulation of FGF signaling by Canopy1 (Cnpy1) controls DFC clustering.
      Title: Canopy1, a positive feedback regulator of FGF signaling, controls progenitor cell clustering during Kupffer's vesicle organogenesis.
    5. Zebrafish piwil2 is a mediator of Fgf signals in gastrula period.
      Title: Piwi-like 2 mediates fibroblast growth factor signaling during gastrulation of zebrafish embryo.
    6. Data suggest that regulation of FGF8 morphogen signalling activity through endocytic sorting allows fast feedback-induced changes in gradient interpretation during the establishment of complex patterns.
      Title: Interpretation of the FGF8 morphogen gradient is regulated by endocytic trafficking.
    7. Fgf has an essential role in establishing the period gradient that is required for the her1 spatial oscillation pattern at the emergence of the traveling wave.
      Title: Emergence of traveling waves in the zebrafish segmentation clock.
    8. Blocking FGF8 restores somite morphology in ChCh and Sip1a compromised embryos.
      Title: Churchill and Sip1a repress fibroblast growth factor signaling during zebrafish somitogenesis.
    9. essential role for Setdb2-Fgf8 signaling in restricting dorsal organizer territory and regulating left-right asymmetry
      Title: Setdb2 restricts dorsal organizer territory and regulates left-right asymmetry through suppressing fgf8 activity.
    10. fgf8a transcriptional regulation employs pan-vertebrate and teleost-specific enhancers dispersed over three genes in the zebrafish genome
      Title: Cis-regulation and chromosomal rearrangement of the fgf8 locus after the teleost/tetrapod split.
    Submit: New GeneRIF Correction See all (37)
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    General gene information

    Markers

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    Kupffer's vesicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT atrial cardiac muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cardiac ventricle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cardioblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cerebellum formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cilium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    determination of dorsal identity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    determination of left/right symmetry IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    dorsal/ventral pattern formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    ectodermal placode formation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    embryonic camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    embryonic heart tube development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    embryonic pattern specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    embryonic retina morphogenesis in camera-type eye IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    endoderm development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    endoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    hindbrain development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    hindbrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    inner ear development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    locus ceruleus development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    mesoderm development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    midbrain development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    midbrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    midbrain-hindbrain boundary development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of endodermal cell fate specification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of endodermal cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    neuron fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    notochord development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    oligodendrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    otic placode formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    otic placode formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    otic vesicle formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    otic vesicle formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    otic vesicle formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    paraxial mesoderm development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    peripheral nervous system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    pharyngeal system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    positive regulation of Wnt receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    positive regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    regulation of bone remodeling IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    regulation of bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    retina development in camera-type eye IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    rhombomere 5 development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    rhombomere 6 development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    somitogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    striated muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    thyroid gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    ventricular cardiac muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    fibroblast growth factor 8
    Names
    fibroblast growth factor 8
    acerebellar
    fibroblast growth factor 8 a
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131281.2 → NP_571356.2  fibroblast growth factor 8 precursor

      Status: PROVISIONAL

      Source sequence(s)
      BC086718
      UniProtKB/TrEMBL
      Q5PRC3
      Related
      ENSDARP00000018653, OTTDARP00000019154, ENSDART00000025583, OTTDART00000022966
      Conserved Domains (1) summary
      cd00058
      Location:54 – 178
      Blast Score: 245
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

    RefSeqs of Annotated Genomes: Build 5.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Zv9 Primary Assembly

    Genomic

    1. NC_007124.5 Reference Zv9 Primary Assembly

      Range
      28719119..28725587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic CR925797.8 (42695..49163) None
    mRNA AB055676.1 None
    mRNA AB274023.1 BAF31291.1
    mRNA AF030560.1 AAB82614.1
    mRNA AF034264.1 AAC60303.1
    mRNA AF051365.1 AAC41302.1
    mRNA BC086718.1 AAH86718.1
    mRNA BC165018.1 AAI65018.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O42278 GenPept UniProtKB/TrEMBL:O42278
    O57341 GenPept UniProtKB/TrEMBL:O57341
    Q0E9Y8 GenPept UniProtKB/TrEMBL:Q0E9Y8
    Q5PRC3 GenPept UniProtKB/TrEMBL:Q5PRC3
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    Additional Links

    Additional Links

    Gene LinkOut

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

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