Serpinc1 serpin peptidase inhibitor, clade C (antithrombin), member 1 [Rattus norvegicus] - Gene

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Summary

Official Symbol: Serpinc1provided by RGD
Official Full Name: serpin peptidase inhibitor, clade C (antithrombin), member 1provided by RGD
Primary source: RGD:1307404
See related: Ensembl:ENSRNOG00000002783
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus

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Genomic context

Location :: 13q22

Sequence :: Chromosome: 13; NC_005112.2 (76548456..76562724)

See Serpinc1 in MapViewer

Chromosome 13 - NC_005112.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

antithrombin diminishes pulmonary endothelial damage induced by crush injury
Title: The effect of antithrombin on pulmonary endothelial damage induced by crush injury.
AT might reduce the I/R-induced liver injury by increasing the production of PGI2 and PGE2 through activation of COX-1. (antithrombin III)
Title: Antithrombin reduces ischemia/reperfusion-induced liver injury in rats by activation of cyclooxygenase-1.

Submit: New GeneRIF Correction

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Function	Evidence Code	Pubs
heparin binding	IDA Inferred from Direct Assay more info	PubMed
protease binding	IEA Inferred from Electronic Annotation more info
protease binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
serine-type endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of proteolysis	IBA Inferred from Biological aspect of Ancestor more info
response to nutrient	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
extracellular space	IDA Inferred from Direct Assay more info	PubMed
extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: antithrombin-III

Names: antithrombin-III; antithrombin III; serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012027.1 → NP_001012027.1 antithrombin-III precursor

Status: PROVISIONAL

Source sequence(s)

BC088467

UniProtKB/TrEMBL

Q5M7T5

Related

ENSRNOP00000003748, ENSRNOT00000003748

Conserved Domains (1) summary

cd02045
Location:80 – 459
Blast Score: 1714

antithrombin-III_like; Antithrombin is a serine proteinase inhibitor (serpin) which controls the process of coagulation. It is the most important anticoagulant molecule in mammalian circulation systems, controlled by its interaction with the co-factor, heparin, which ...