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Ube2o ubiquitin-conjugating enzyme E2O [ Rattus norvegicus (Norway rat) ]

Gene ID: 303689, updated on 13-Apr-2024

Summary

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Official Symbol
Ube2oprovided by RGD
Official Full Name
ubiquitin-conjugating enzyme E2Oprovided by RGD
Primary source
RGD:1310297
See related
Ensembl:ENSRNOG00000011007 AllianceGenome:RGD:1310297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310297
Summary
Predicted to enable cysteine-type endopeptidase inhibitor activity; ubiquitin conjugating enzyme activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of BMP signaling pathway; protein ubiquitination; and retrograde transport, endosome to Golgi. Predicted to be located in cytoplasm and nuclear body. Predicted to be active in nucleus. Orthologous to human UBE2O (ubiquitin conjugating enzyme E2 O). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 394.1), Brain (RPKM 140.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q32.2
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (102264418..102311578, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (101765572..101812736, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (105505721..105553167, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene phosphoribosyl pyrophosphate synthetase-associated protein 1 Neighboring gene sphk1a antisense transcript Neighboring gene sphingosine kinase 1 Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L14, pseudogene 1 Neighboring gene aralkylamine N-acetyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O. Mashtalir N, et al. Mol Cell, 2014 May 8. PMID 24703950
  2. Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6. Zhang X, et al. EMBO J, 2013 Apr 3. PMID 23455153, Free PMC Article
  3. Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Hao YH, et al. Cell, 2013 Feb 28. PMID 23452853, Free PMC Article
  4. Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch. Mössinger J, et al. EMBO Rep, 2012 Dec. PMID 23146885, Free PMC Article
  5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
(E3-independent) E2 ubiquitin-conjugating enzyme
NP_001414251.1
XP_017453235.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427322.1 → NP_001414251.1  (E3-independent) E2 ubiquitin-conjugating enzyme

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6A0W6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    102264418..102311578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597746.3 → XP_017453235.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X1

    UniProtKB/TrEMBL
    A6HKX6
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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