Igf2bp1 insulin-like growth factor 2 mRNA binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Igf2bp1provided by RGD
Official Full Name: insulin-like growth factor 2 mRNA binding protein 1provided by RGD
Primary source: RGD:708580
See related: Ensembl:ENSRNOG00000006122 AllianceGenome:RGD:708580
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Imp1; ZBP1
Summary: Enables mRNA 3'-UTR binding activity. Involved in RNA localization and dendrite arborization. Located in axon; dendritic spine; and neuronal cell body. Orthologous to human IGF2BP1 (insulin like growth factor 2 mRNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 9.3), Kidney (RPKM 6.7) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (81405021..81447814, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (80908300..80951097, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (83774178..83823323, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data support a role for SMN in the regulation of mRNA localization and axonal transport through its interaction with mRNA-binding proteins such as IMP1
Title: Dynamics of survival of motor neuron (SMN) protein interaction with the mRNA-binding protein IMP1 facilitates its trafficking into motor neuron axons.
This study suggested a novel regulatory role for MyoVa in the transport of ZBP1 within axons.
Title: Regulation of zipcode binding protein 1 transport dynamics in axons by myosin Va.
These results suggest that ZBP1-dependent dendritic mRNA transport contributes to proper dendritic branching.
Title: Zipcode binding protein 1 regulates the development of dendritic arbors in hippocampal neurons.
IMP1 plays a role in regulating the packaging of MLV genomic RNA and can be used for improving production of retroviral vectors
Title: Expression of IMP1 enhances production of murine leukemia virus vector by facilitating viral genomic RNA packaging.
These results indicate that phosphorylation of ZBP1 at Tyr396 within growth cones has a critical role to regulate local protein synthesis and growth cone turning.
Title: Phosphorylation of zipcode binding protein 1 is required for brain-derived neurotrophic factor signaling of local beta-actin synthesis and growth cone turning.
These experiments suggest that in breast cancer cells, the expression of ZBP1 and the expression of beta-catenin are coordinately regulated.
Title: Feedback regulation between zipcode binding protein 1 and beta-catenin mRNAs in breast cancer cells.
ZBP1 expression resulted in tumor cells with a stable polarized phenotype, and reduced their ability to move in response to a gradient in culture.
Title: ZBP1 enhances cell polarity and reduces chemotaxis.
ZBP1 is required for the localization of beta-actin mRNA to dendrites of hippocampal neurons
Title: Localization of a beta-actin messenger ribonucleoprotein complex with zipcode-binding protein modulates the density of dendritic filopodia and filopodial synapses.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:498743 (e-PCR)
- UniSTS:498743

Igf2bp1 (e-PCR), detects polymorphism
- UniSTS:498743

Igf2bp1 (e-PCR), detects polymorphism
- UniSTS:479166

BI276370 (e-PCR)
- UniSTS:249852

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N6-methyladenosine-containing RNA reader activity	ISO Inferred from Sequence Orthology more info
enables N6-methyladenosine-containing RNA reader activity	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 5'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables translation regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CRD-mediated mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in CRD-mediated mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in CRD-mediated mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in RNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite arborization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuronal stem cell population maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pallium cell proliferation in forebrain	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytoplasmic translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA stability involved in response to stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA stability involved in response to stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CRD-mediated mRNA stability complex	ISO Inferred from Sequence Orthology more info
part_of CRD-mediated mRNA stability complex	ISS Inferred from Sequence or Structural Similarity more info
located_in P-body	IEA Inferred from Electronic Annotation more info
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: insulin-like growth factor 2 mRNA-binding protein 1

Names: B-actin zipcode-binding protein 1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding protein 1; IMP-1; VICKZ family member 1; insulin-like growth factor 2, binding protein 1; rZBP-1; zipcode-binding protein-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175594.2 → NP_783184.1 insulin-like growth factor 2 mRNA-binding protein 1

See identical proteins and their annotated locations for NP_783184.1

Status: PROVISIONAL

Source sequence(s)

AF541940

UniProtKB/Swiss-Prot

B1WBP3, Q8CGX0

UniProtKB/TrEMBL

A0A8I6AN86

Related

ENSRNOP00000008139.3, ENSRNOT00000008139.6

Conserved Domains (3) summary

cd12625
Location:1 → 77

RRM1_IGF2BP1; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)

cd12628
Location:81 → 156

RRM2_IGF2BP1; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)

cl00098
Location:273 → 369

KH-I; K homology (KH) RNA-binding domain, type I