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Zfp287 zinc finger protein 287 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303212, updated on 30-Mar-2024

Summary

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Official Symbol
Zfp287provided by RGD
Official Full Name
zinc finger protein 287provided by RGD
Primary source
RGD:1308617
See related
Ensembl:ENSRNOG00000003215 AllianceGenome:RGD:1308617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Znf287
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription, DNA-templated and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of cytokine production. Predicted to be active in nucleus. Orthologous to human ZNF287 (zinc finger protein 287). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 37.6), Lung (RPKM 35.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (47896517..47914860, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (47395650..47415610, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (49131764..49150930, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 75A Neighboring gene uncharacterized LOC120095115 Neighboring gene membrane magnesium transporter 2 Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA tryptophan (anticodon CCA) 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of SKAT-2, a novel Th2-specific zinc finger gene. Blanchard AD, et al. Eur J Immunol, 2000 Nov. PMID 11093124
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 287

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107008.2 → NP_001100478.1  zinc finger protein 287

    See identical proteins and their annotated locations for NP_001100478.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HFB9, D4A516
    Related
    ENSRNOP00000004291.4, ENSRNOT00000004291.6
    Conserved Domains (7) summary
    smart00349
    Location:168 → 225
    KRAB; krueppel associated box
    COG5048
    Location:420 → 752
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:424 → 444
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:590 → 612
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:168 → 207
    KRAB; KRAB box
    pfam02023
    Location:46 → 133
    SCAN; SCAN domain
    pfam13465
    Location:604 → 629
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    47896517..47914860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246692.5 → XP_006246754.1  zinc finger protein 287 isoform X1

    See identical proteins and their annotated locations for XP_006246754.1

    UniProtKB/TrEMBL
    A6HFB9, D4A516
    Conserved Domains (7) summary
    smart00349
    Location:168 → 225
    KRAB; krueppel associated box
    COG5048
    Location:420 → 752
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:424 → 444
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:590 → 612
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:168 → 207
    KRAB; KRAB box
    pfam02023
    Location:46 → 133
    SCAN; SCAN domain
    pfam13465
    Location:604 → 629
    zf-H2C2_2; Zinc-finger double domain

  2. XM_017597279.3 → XP_017452768.1  zinc finger protein 287 isoform X2

  3. XM_039085973.2 → XP_038941901.1  zinc finger protein 287 isoform X3

    Conserved Domains (2) summary
    smart00349
    Location:168 → 225
    KRAB; krueppel associated box
    cl02605
    Location:46 → 144
    SCAN; SCAN oligomerization domain

RNA

  1. XR_005489814.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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