Sign in to NCBI

Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    tcf3 transcription factor 3 [ Danio rerio (zebrafish) ]

    Gene ID: 30310, updated on 21-Feb-2013
    Official Symbol
    tcf3provided by ZNC
    Official Full Name
    transcription factor 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-51
    See related
    Ensembl:ENSDARG00000005915
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    e12; zfe12; zgc:113926
    Annotation information
    Annotation category: partial on reference assembly
    Location :
    chromosome: 2
    Sequence :
    Chromosome: 2; NC_007113.5 (57776841..57853664, complement)
    See tcf3 in MapViewer

    Chromosome 2 - NC_007113.5Genomic Context describing neighboring genes Neighboring gene methyl-CpG binding domain protein 3a Neighboring gene uncharacterized LOC100331115 Neighboring gene mitogen-activated protein kinase kinase 2b Neighboring gene protein inhibitor of activated STAT, 4b

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Tcf3 function is required for the inhibition of oligodendroglial fate specification in the spinal cord of zebrafish embryos. Kim S, et al. Mol Cells, 2011 Oct. PMID 21904879.
    2. Zebrafish krüppel-like factor 4a represses intestinal cell proliferation and promotes differentiation of intestinal cell lineages. Li IC, et al. PLoS One, 2011. PMID 21687630.
    3. Modulation of Tcf3 repressor complex composition regulates cdx4 expression in zebrafish. Ro H, et al. EMBO J, 2011 Jun 10. PMID 21666599.
    4. Wnt signaling is required for early development of zebrafish swimbladder. Yin A, et al. PLoS One, 2011 Mar 30. PMID 21479192.
    5. SoxB1 transcription factors restrict organizer gene expression by repressing multiple events downstream of Wnt signalling. Shih YH, et al. Development, 2010 Aug. PMID 20610482.

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. regulates the oligodendroglial cell differentiation in the spinal cord
      Title: Tcf3 function is required for the inhibition of oligodendroglial fate specification in the spinal cord of zebrafish embryos.
    2. Tcf3 is required to inhibit premature neurogenesis in spinal progenitors by repressing sox4a, a known mediator of spinal neurogenesis
      Title: Tcf3 inhibits spinal cord neurogenesis by regulating sox4a expression.
    Submit: New GeneRIF Correction

    Markers

    Clone Names

    • MGC113926

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    striated muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Preferred Names
    transcription factor 3
    Names
    transcription factor 3
    E2A
    Tcf3b
    human E12 homolog
    TCF3 transcription factor 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131094.1 → NP_571169.1  transcription factor 3

      Status: PROVISIONAL

      Source sequence(s)
      X76997
      UniProtKB/TrEMBL
      Q90491
      Related
      ENSDARP00000010044, ENSDART00000020529
      Conserved Domains (1) summary
      smart00353
      Location:501 – 547
      Blast Score: 118
      HLH; helix loop helix domain

    RefSeqs of Annotated Genomes: Build 5.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Zv9 Primary Assembly

    Genomic

    1. NC_007113.5 Reference Zv9 Primary Assembly

      Range
      57776841..57853664, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic CABZ01044193.1 (7001..21071) None
    genomic CR391909.16 (1413..62653) None
    mRNA BC100122.1 AAI00123.1
    mRNA X76997.1 CAA54305.1 wild type

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...