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Usp26 ubiquitin specific peptidase 26 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302488, updated on 5-Mar-2024

Summary

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Symbol
Usp26provided by RGD
Full Name
ubiquitin specific peptidase 26provided by RGD
Primary source
RGD:1563443
See related
Ensembl:ENSRNOG00000029106 AllianceGenome:RGD:1563443
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563443
Summary
Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in G1/S transition of mitotic cell cycle and protein deubiquitination. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human USP26 (ubiquitin specific peptidase 26). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 92.1) and Kidney (RPKM 26.0) See more
Orthologs
human mouse all
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Genomic context

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See Usp26 in Genome Data Viewer
Location:
Xq36
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (136237504..136284646, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (131317200..131363964, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (139030239..139079336, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene high mobility group protein B4-like Neighboring gene heparan sulfate 6-O-sulfotransferase 2 Neighboring gene mitochondrial ribosomal protein L30, pseudogene 3 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 3, pseudogene 1 Neighboring gene uncharacterized LOC102550607 Neighboring gene MAGE family member A14 Neighboring gene high mobility group protein B4-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling. Dirac AM, et al. Mol Cancer Res, 2010 Jun. PMID 20501646
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 26
NP_001100418.1
XP_038955531.1
XP_038955533.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106948.1 → NP_001100418.1  ubiquitin carboxyl-terminal hydrolase 26

    See identical proteins and their annotated locations for NP_001100418.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473991
    UniProtKB/TrEMBL
    A6JMT7, D4A5S1
    Related
    ENSRNOP00000047375.3, ENSRNOT00000047605.6
    Conserved Domains (4) summary
    COG5077
    Location:181 → 378
    COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cl02553
    Location:740 → 805
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:288 → 557
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 103
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    136237504..136284646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099603.2 → XP_038955531.1  ubiquitin carboxyl-terminal hydrolase 26 isoform X1

    UniProtKB/TrEMBL
    A6JMT7, D4A5S1
    Related
    ENSRNOP00000085992.1
    Conserved Domains (4) summary
    COG5077
    Location:181 → 378
    COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cl02553
    Location:740 → 805
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:288 → 557
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 103
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

  2. XM_039099605.2 → XP_038955533.1  ubiquitin carboxyl-terminal hydrolase 26 isoform X1

    UniProtKB/TrEMBL
    A6JMT7, D4A5S1
    Conserved Domains (4) summary
    COG5077
    Location:181 → 378
    COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cl02553
    Location:740 → 805
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:288 → 557
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 103
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
Nucleotide Protein Strain
Heading Accession and Version

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