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Tert telomerase reverse transcriptase [ Rattus norvegicus (Norway rat) ]

Gene ID: 301965, updated on 26-May-2016
Official Symbol
Tertprovided by RGD
Official Full Name
telomerase reverse transcriptaseprovided by RGD
Primary source
RGD:70494
See related
Ensembl:ENSRNOG00000025327
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Orthologs
Location:
1p11
Exon count:
16
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (32250876..32273711, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (33675744..33697542, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 18 Neighboring gene RNA polymerase II transcriptional coactivator-like Neighboring gene CLPTM1-like Neighboring gene uncharacterized LOC102548924 Neighboring gene solute carrier family 6 member 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
 
RNA-directed RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to RNA-directed RNA polymerase activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotidyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
tRNA binding IEA
Inferred from Electronic Annotation
more info
 
tRNA binding ISO
Inferred from Sequence Orthology
more info
 
telomerase RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
telomerase RNA binding ISO
Inferred from Sequence Orthology
more info
 
telomerase RNA reverse transcriptase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to telomerase RNA reverse transcriptase activity ISO
Inferred from Sequence Orthology
more info
 
telomerase RNA reverse transcriptase activity TAS
Traceable Author Statement
more info
PubMed 
telomerase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to telomerase activity ISO
Inferred from Sequence Orthology
more info
 
telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription coactivator binding IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
DNA strand elongation IEA
Inferred from Electronic Annotation
more info
 
DNA strand elongation ISO
Inferred from Sequence Orthology
more info
 
RNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
RNA-dependent DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
establishment of protein localization to telomere ISO
Inferred from Sequence Orthology
more info
 
mitochondrion organization IEA
Inferred from Electronic Annotation
more info
 
mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cellular senescence IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of production of siRNA involved in RNA interference IEA
Inferred from Electronic Annotation
more info
 
negative regulation of production of siRNA involved in RNA interference ISO
Inferred from Sequence Orthology
more info
 
positive regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hair cycle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hair cycle ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pri-miRNA transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of pri-miRNA transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to nucleolus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein localization to nucleolus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transdifferentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vascular associated smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vascular smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
production of siRNA involved in RNA interference IEA
Inferred from Electronic Annotation
more info
 
production of siRNA involved in RNA interference ISO
Inferred from Sequence Orthology
more info
 
regulation of protein stability IEA
Inferred from Electronic Annotation
more info
 
regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
replicative senescence IEA
Inferred from Electronic Annotation
more info
 
replicative senescence ISO
Inferred from Sequence Orthology
more info
 
response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
 
telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
transcription, RNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, RNA-templated ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
PML body IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with PML body ISO
Inferred from Sequence Orthology
more info
 
RNA-directed RNA polymerase complex ISO
Inferred from Sequence Orthology
more info
 
TERT-RMRP complex IEA
Inferred from Electronic Annotation
more info
 
TERT-RMRP complex ISO
Inferred from Sequence Orthology
more info
 
chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
mitochondrial nucleoid IEA
Inferred from Electronic Annotation
more info
 
mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nuclear chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
telomerase catalytic core complex IBA
Inferred from Biological aspect of Ancestor
more info
 
telomerase catalytic core complex ISO
Inferred from Sequence Orthology
more info
 
telomerase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
telomerase reverse transcriptase
Names
telomerase catalytic subunit
NP_445875.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053423.1NP_445875.1  telomerase reverse transcriptase

    See identical proteins and their annotated locations for NP_445875.1

    Status: PROVISIONAL

    Source sequence(s)
    AY539717
    UniProtKB/Swiss-Prot
    Q673L6
    Related
    ENSRNOP00000022683, ENSRNOT00000022683
    Conserved Domains (2) summary
    smart00975
    Location:450584
    Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
    cd01648
    Location:816929
    TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    32250876..32273711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008758683.1XP_008756905.1  

    Conserved Domains (2) summary
    smart00975
    Location:454588
    Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
    cd01648
    Location:820933
    TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...
  2. XM_008758684.1XP_008756906.1  

    Conserved Domains (2) summary
    smart00975
    Location:454588
    Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
    cd01648
    Location:820933
    TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...

RNA

  1. XR_589899.1 RNA Sequence

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    28286050..28306805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001007019.1: Suppressed sequence

    Description
    NM_001007019.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript or protein.