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H2AFZ H2A histone family, member Z [ Homo sapiens (human) ]

Gene ID: 3015, updated on 17-Apr-2014
Official Symbol
H2AFZprovided by HGNC
Official Full Name
H2A histone family, member Zprovided by HGNC
Primary source
HGNC:4741
See related
Ensembl:ENSG00000164032; HPRD:00823; MIM:142763; Vega:OTTHUMG00000131048
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H2AZ; H2A.z; H2A/z; H2A.Z-1
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq, Jul 2008]
Location :
4q24
Sequence :
Chromosome: 4; NC_000004.12 (99948085..99950355, complement)
See H2AFZ in Epigenomics, MapViewer

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 14 Neighboring gene uncharacterized LOC256880 Neighboring gene ribosomal protein L7-like 1 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat, p14 tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cellular response to estradiol stimulus IMP
Inferred from Mutant Phenotype
more info
 
nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
NOT Barr body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
histone H2A.Z
Names
histone H2A.Z
H2AZ histone

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002106.3NP_002097.1  histone H2A.Z

    See proteins identical to NP_002097.1

    Status: REVIEWED

    Source sequence(s)
    BC020936, CD685635, M37583
    Consensus CDS
    CCDS3654.1
    UniProtKB/Swiss-Prot
    P0C0S5
    Related
    ENSP00000296417, OTTHUMP00000161678, ENST00000296417, OTTHUMT00000253695
    Conserved Domains (2) summary
    PTZ00017
    Location:3128
    Blast Score: 475
    PTZ00017; histone H2A; Provisional
    cd00074
    Location:8122
    Blast Score: 461
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000004.12

    Range
    99948085..99950355, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262971.1XP_005263028.1  

    Conserved Domains (1) summary
    cd00074
    Location:8111
    Blast Score: 435
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

Alternate HuRef

Genomic

  1. AC_000136.1 Alternate HuRef

    Range
    96607568..96609836, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    100845766..100848034, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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