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    ANXA1 annexin A1 [ Homo sapiens ]

    Gene ID: 301, updated on 14-May-2012
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    Summary

    Official Symbol
    ANXA1provided by HGNC
    Official Full Name
    annexin A1provided by HGNC
    Primary source
    HGNC:533
    Locus tag
    RP11-71A24.1
    See related
    Ensembl:ENSG00000135046; HPRD:01060; MIM:151690; Vega:OTTHUMG00000020016
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANX1; LPC1
    Summary
    Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    9q21.13
    Sequence :
    Chromosome: 9; NC_000009.11 (75766781..75785307)
    See ANXA1 in Epigenomics, MapViewer

    Chromosome 9 - NC_000009.11Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 1 family, member A1 Neighboring gene cytochrome P450, family 1, subfamily D, polypeptide 1, pseudogene Neighboring gene dipeptidyl-peptidase 3 pseudogene Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic "find-me" signal. Blume KE, et al. J Immunol, 2012 Jan 1. PMID 22116825.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28. Wong PF, et al. Phytomedicine, 2012 Jan 15. PMID 21903368.
    4. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.

    See all (146) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Eurycomanone suppresses the expression of annexin 1 or lipocortin I protein that is involved in cell proliferation and differentiation.
      Title: Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28.
    2. Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic "find-me" signal.
      Title: Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic "find-me" signal.
    3. Activation of the annexin A1 pathway underlies the protective effects exerted by estrogen in polymorphonuclear leukocytes.
      Title: Activation of the annexin A1 pathway underlies the protective effects exerted by estrogen in polymorphonuclear leukocytes.
    4. Expression of ANXs was different in histologic subtypes of penile carcinomas. Strong expression of ANX AI and ANX AIV in the invasion front seems to indicate a higher risk of lymph node metastasis.
      Title: The role of annexins I, II and IV in tumor development, progression and metastasis of human penile squamous cell carcinomas.
    5. ANXA1 can constitutively activate NF-kappaB in breast cancer cells through the interaction with the IKK complex
      Title: Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-κB: implication in breast cancer metastasis.
    6. Data sugget the existence of an endogenous network in anti-inflammation centered on PMN AnxA1 and activated by selective FPR2/ALX agonists.
      Title: Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature.
    7. Annexin A1 seemed to be positively upregulated during starvation to promote autophagic degradation.
      Title: Proteomics analysis of starved cells revealed Annexin A1 as an important regulator of autophagic degradation.
    8. The Annexin A1 is proposed to function importantly in the progression of lung adenorcinoma.
      Title: Identification of annexin A1 as a proinvasive and prognostic factor for lung adenocarcinoma.
    9. The benign lesions with positive ANXA1 and/or ANXA2 expression showed mild to severe atypical hyperplasia of the gallbladder epithelium. The positive rates of ANXA1 and/or ANXA2 were significantly lower in the well-differentiated adenocarcinoma.
      Title: [Expression of annexin A1 (ANXA1) and A2 (ANXA2) and its significance in benign and malignant lesions of gallbladder].
    10. MG53, annexin A1, and dysferlin localize to the t-tubule network and show enriched labeling at longitudinal tubules of the t-system in overstretch
      Title: Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch.
    Submit: New GeneRIF Correction See all (97)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P04083 O75923 DYSF    HPRD  PubMed  
    P04083 P00533 EGFR    HPRD  PubMed  
    P04083 P21462 FPR1    HPRD  PubMed  
    P04083 P05787 KRT8    HPRD  PubMed  
    P04083 P41743 PRKCI    HPRD  PubMed  
    P04083 P31949 S100A11    HPRD  PubMed  
    P04083 P12931 SRC    HPRD  PubMed  
    P04083 P21980 TGM2    HPRD  PubMed  
    P04083 Q96QT4 TRPM7    HPRD  PubMed  
    BioGRID:106798 BioGRID:106819 APBB1    BioGRID  PubMed Two-hybrid 
    BioGRID:106798 BioGRID:116801 ATG4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106798 BioGRID:116332 C14orf1    BioGRID  PubMed Two-hybrid 
    BioGRID:106798 BioGRID:120322 C1orf123    BioGRID  PubMed Two-hybrid 
    BioGRID:106798 BioGRID:115825 CCT7    BioGRID  PubMed Two-hybrid 
    BioGRID:106798 BioGRID:107358 CD4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106798 BioGRID:116176 COPS6    BioGRID  PubMed Two-hybrid 
    BioGRID:106798 BioGRID:119512 CSAD    BioGRID  PubMed Two-hybrid 
    BioGRID:106798 BioGRID:108085 DLG3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106798 BioGRID:116298 FAF1    BioGRID  PubMed Two-hybrid 
    BioGRID:106798 BioGRID:108868 GAPDH    BioGRID  PubMed Two-hybrid 
    BioGRID:106798 BioGRID:127354 KLHL23    BioGRID  PubMed Two-hybrid 
    BioGRID:106798 BioGRID:110054 KRT8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106798 BioGRID:120905 LRIF1    BioGRID  PubMed Two-hybrid 
    BioGRID:106798 BioGRID:110411 MGMT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106798 BioGRID:115104 MLL4    BioGRID  PubMed Two-hybrid 
    BioGRID:106798 BioGRID:120751 OTUB1    BioGRID  PubMed Two-hybrid 
    BioGRID:106798 BioGRID:111490 PPM1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106798 BioGRID:112037 RPA1    BioGRID  PubMed Two-hybrid 
    BioGRID:106798 BioGRID:112190 S100A11    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106798 BioGRID:122479 SLX1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106798 BioGRID:113188 SUMO1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106798 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106798 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106798 BioGRID:113169 UBE2D1    BioGRID  PubMed Two-hybrid 
    BioGRID:106798 BioGRID:113177 UBE2I    BioGRID  PubMed Biochemical Activity 
    BioGRID:106798 BioGRID:113185 UBE3A    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106798 BioGRID:119509 UCHL5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106798 BioGRID:114548 UNC119    BioGRID  PubMed Two-hybrid 
    BioGRID:106798 BioGRID:118895 USP25    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106798 BioGRID:115503 USPL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106798 BioGRID:108822 XRCC6    BioGRID  PubMed Two-hybrid 
    BioGRID:106798 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • Formyl peptide receptors bind formyl peptides and many other ligands, organism-specific biosystem (from REACTOME)
      Formyl peptide receptors bind formyl peptides and many other ligands, organism-specific biosystemThe formyl peptide receptor (FPR) was defined pharmacologically in 1976 as a high affinity binding site on the surface of neutrophils for the peptide N-formyl-methionine-leucine-phenylalanine (fMLF)....
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Prostaglandin Synthesis and Regulation, organism-specific biosystem (from WikiPathways)
      Prostaglandin Synthesis and Regulation, organism-specific biosystem
      Prostaglandin Synthesis and Regulation
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    calcium-dependent phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    phospholipase A2 inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    phospholipase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    phospholipase inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    phospholipid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    protein binding, bridging IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    single-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    structural molecule activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    alpha-beta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    alpha-beta T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    anti-apoptosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    arachidonic acid secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular component movement TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
    		  
    endocrine pancreas development IEA
    Inferred from Electronic Annotation
    more info
    		  
    estrous cycle phase IEA
    Inferred from Electronic Annotation
    more info
    		  
    gliogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    hepatocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    inflammatory response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    insulin secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    keratinocyte differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    lipid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of acute inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of protein secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    peptide cross-linking IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of prostaglandin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to X-ray IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to drug IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to glucocorticoid stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to peptide hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    cornified envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
    		  
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    annexin A1
    Names
    annexin A1
    p35
    annexin-1
    calpactin-2
    calpactin II
    lipocortin I
    chromobindin-9
    annexin I (lipocortin I)
    phospholipase A2 inhibitory protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000700.1 → NP_000691.1  annexin A1

      Status: REVIEWED

      Source sequence(s)
      X05908
      Consensus CDS
      CCDS6645.1
      UniProtKB/Swiss-Prot
      P04083
      UniProtKB/TrEMBL
      Q5TZZ9
      Related
      ENSP00000257497, OTTHUMP00000021474, ENST00000257497, OTTHUMT00000052664
      Conserved Domains (1) summary
      cl02574
      Location:118 – 183
      Blast Score: 243
      Annexin; Annexin

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000009.11 Reference GRCh37.p5 Primary Assembly

      Range
      75766781..75785307
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000141.1 Alternate HuRef

      Range
      45589147..45607684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL359997.8 CAI16494.1
      CAI16495.1
      CAI16496.1
    genomic CH471089.1 EAW62545.1
      EAW62546.1
      EAW62547.1
      EAW62548.1
      EAW62549.1
      EAW62550.1
    genomic U25414.1 None
    mRNA AB451274.1 BAG70088.1
    mRNA AB451401.1 BAG70215.1
    mRNA AK074480.1 None
    mRNA AK296808.1 BAG59381.1
    mRNA BC001275.1 AAH01275.1
    mRNA BC018683.1 None
    mRNA BC034157.1 AAH34157.1
    mRNA BC035993.1 AAH35993.1
    mRNA BT019896.1 AAV38699.1
    mRNA BT019916.1 AAV38719.1
    mRNA BT019917.1 AAV38720.1
    mRNA CR407684.1 CAG28612.1
    mRNA X05908.1 CAA29338.1
    other-genetic DQ891173.2 ABM82099.1
    other-genetic DQ894338.2 ABM85264.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04083.2 GenPept UniProtKB/Swiss-Prot:P04083
    Q05BR2 GenPept UniProtKB/TrEMBL:Q05BR2
    Q5T3N0 GenPept UniProtKB/TrEMBL:Q5T3N0
    Q5T3N1 GenPept UniProtKB/TrEMBL:Q5T3N1
    Q5TZZ9 GenPept UniProtKB/TrEMBL:Q5TZZ9
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
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