Nck1 NCK adaptor protein 1 [Rattus norvegicus] - Gene

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Summary

Official Symbol: Nck1provided by RGD
Official Full Name: NCK adaptor protein 1provided by RGD
Primary source: RGD:1310688
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus

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Genomic context

Location :: 8q31

Sequence :: Chromosome: 8; NC_005107.2 (105346933..105409843, complement)

See Nck1 in MapViewer

Chromosome 8 - NC_005107.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Nck is required to maintain adult podocytes and phosphotyrosine-based interactions with nephrin may occur in foot processes of resting, mature podocytes.
Title: Nck proteins maintain the adult glomerular filtration barrier.
Modulation of protein translation by Nck-1.
Title: Modulation of protein translation by Nck-1.
Nck couples nephrin to the actin cytoskeleton in glomerular podocytes and contributes to the maintenance of normal morphology and function of podocytes
Title: Rat nephrin modulates cell morphology via the adaptor protein Nck.

Submit: New GeneRIF Correction

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Function	Evidence Code	Pubs
kinase activity	IEA Inferred from Electronic Annotation more info
protein domain specific binding	ISO Inferred from Sequence Orthology more info
receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
T cell activation	ISO Inferred from Sequence Orthology more info
actin filament organization	ISO Inferred from Sequence Orthology more info
cell migration	ISO Inferred from Sequence Orthology more info
lamellipodium assembly	ISO Inferred from Sequence Orthology more info
positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: cytoplasmic protein NCK1

Names: cytoplasmic protein NCK1; non-catalytic region of tyrosine kinase adaptor protein 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106851.2 → NP_001100321.1 cytoplasmic protein NCK1

Status: PROVISIONAL

Source sequence(s)

BC167009

UniProtKB/TrEMBL

B2RZ33

Conserved Domains (2) summary

cd00174
Location:194 – 249
Blast Score: 169

SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...

cd10408
Location:280 – 376
Blast Score: 519

SH2_Nck1; Src homology 2 (SH2) domain found in Nck