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    HIST1H1C histone cluster 1, H1c [ Homo sapiens ]

    Gene ID: 3006, updated on 15-May-2012
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    Summary

    Official Symbol
    HIST1H1Cprovided by HGNC
    Official Full Name
    histone cluster 1, H1cprovided by HGNC
    Primary source
    HGNC:4716
    See related
    Ensembl:ENSG00000187837; HPRD:07514; MIM:142710; Vega:OTTHUMG00000016140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H1C; H1.2; H1F2; H1s-1; MGC3992
    Summary
    Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    6p21.3
    Sequence :
    Chromosome: 6; NC_000006.11 (26055968..26056699, complement)
    See HIST1H1C in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene histone cluster 1, H2a, pseudogene 5 Neighboring gene histone cluster 1, H3c Neighboring gene hemochromatosis Neighboring gene histone cluster 1, H4c

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Lopitz-Otsoa F, et al. J Proteomics, 2012 Jun 6. PMID 22178446.
    2. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    3. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    4. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). Zhao J, et al. J Proteomics, 2011 Dec 21. PMID 21907836.
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.

    See all (48) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
    2. Histone H1.2 was translocated from the nucleus to the mitochondria after treatment with bleomycin and co-localized with Bak in mitochondria.
      Title: Histone H1.2 is translocated to mitochondria and associates with Bak in bleomycin-induced apoptotic cells.
    3. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease.
    4. that the recruitment of YB1, PURalpha, and H1.2 to the p53 target gene Bax is required for repression of p53-induced transcription.
      Title: Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcription.
    5. confirmed N-terminal acetylation on all isoforms plus a single internal acetylation site; phosphorylation sites were located on peptides containing the cyclin dependent kinase (CDK) consensus motif
      Title: Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry.
    6. The binding of histone H1 to a general amyloid-like motif indicates that histone H1 may play an important common role in diseases associated with amyloid-like fibrils.
      Title: Linker histone H1 binds to disease associated amyloid-like fibrils.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P16403 P00742 F10    HPRD  PubMed  
    P16403 P49321 NASP    HPRD  PubMed  
    BioGRID:109261 BioGRID:125736 AEBP2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109261 BioGRID:128104 ASXL1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109261 BioGRID:107487 CENPA    BioGRID  PubMed Co-purification 
    BioGRID:109261 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109261 BioGRID:124082 DOT1L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109261 BioGRID:114265 EED    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109261 BioGRID:111596 EIF2AK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109261 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109261 BioGRID:109318 HDGF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109261 BioGRID:119322 IRAK4    BioGRID  PubMed Biochemical Activity 
    BioGRID:109261 BioGRID:135514 KPNA7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109261 BioGRID:110035 KPNB1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109261 BioGRID:204968 Mapk13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109261 BioGRID:110771 NCL    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109261 BioGRID:110929 NPM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109261 BioGRID:110994 OAS3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109261 BioGRID:106652 PARP1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109261 BioGRID:111564 PRKCA    BioGRID  PubMed Biochemical Activity 
    BioGRID:109261 BioGRID:111577 PRKDC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109261 BioGRID:116502 PUF60    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109261 BioGRID:114952 RBM39    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109261 BioGRID:123598 RNF146    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109261 BioGRID:113188 SUMO1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109261 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109261 BioGRID:117059 SUZ12    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109261 BioGRID:113003 TOP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109261 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109261 BioGRID:120877 WDR12    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109261 BioGRID:116272 WDR5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109261 BioGRID:110959 YBX1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109261 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation of DNA fragmentation factor, organism-specific biosystem (from REACTOME)
      Activation of DNA fragmentation factor, organism-specific biosystemDNA fragmentation in response to apoptotic signals is achieved, in part, through the activity of apoptotic nucleases, termed DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) (reviewed ...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis induced DNA fragmentation, organism-specific biosystem (from REACTOME)
      Apoptosis induced DNA fragmentation, organism-specific biosystemDNA fragmentation in response to apoptotic signals is achieved through the activity of two apoptotic nucleases, termed DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease...
    • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
      Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    nucleosome assembly NAS
    Non-traceable Author Statement
    more info
    		  
    nucleosome positioning IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleosome NAS
    Non-traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    histone H1.2
    Names
    histone H1.2
    histone H1d
    histone 1, H1c
    H1 histone family, member 2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005319.3 → NP_005310.1  histone H1.2

      Status: REVIEWED

      Source sequence(s)
      U91328
      Consensus CDS
      CCDS4577.1
      UniProtKB/TrEMBL
      A8K4I2
      UniProtKB/Swiss-Prot
      P16403
      Related
      ENSP00000339566, OTTHUMP00000017749, ENST00000343677, OTTHUMT00000043372
      Conserved Domains (1) summary
      cd00073
      Location:34 – 115
      Blast Score: 155
      H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      26055968..26056699, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      25999033..25999764, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF531300.1 AAN06700.1
    genomic CH471087.1 EAW55515.1
    genomic U91328.1 (84587..85318) None
    genomic X57129.1 CAA40408.1
    mRNA AB451259.1 BAG70073.1
    mRNA AB451385.1 BAG70199.1
    mRNA AK290947.1 BAF83636.1
    mRNA BC002649.1 None
    other-genetic EU446960.1 ABZ92489.1
    other-genetic EU832089.1 ACE87439.1
    other-genetic EU832181.1 ACE86751.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16403.2 GenPept UniProtKB/Swiss-Prot:P16403
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
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      Supplemental Content

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