TBX21 T-box 21 [Homo sapiens] - Gene

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Summary

Official Symbol: TBX21provided by HGNC
Official Full Name: T-box 21provided by HGNC
Primary source: HGNC:11599
See related: Ensembl:ENSG00000073861; HPRD:05355; MIM:604895
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TBET; T-PET; T-bet; TBLYM
Summary: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 17q21.32

Sequence :: Chromosome: 17; NC_000017.10 (45810610..45823485)

See TBX21 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results indicate that single nucleotide polymorphisms in TBX21 and STAT4 might contribute to susceptibility to aplastic anemia (AA) in the Chinese population.
Title: The polymorphisms of T cell-specific TBX21 and STAT4 genes may contribute to the susceptibility of Chinese individuals to aplastic anemia.
Data suggest that TBX21 -1993 polymorphism might contribute to the risk of gastric cancer, especially to the distant metastasis.
Title: Association between gastric cancer and -1993 polymorphism of TBX21 gene.
mice lacking both transcription factors Eomesodermin (Eomes) and T-bet failed to develop NK cells
Title: The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation.
the T-1993C polymorphism in the TBX21 promoter influences susceptibility to type 1 autoimmune hepatitis in a Chinese population
Title: Association of TBX21 promoter polymorphisms with type 1 autoimmune hepatitis in a Chinese population.
Compared with the normal controls, T-bet mRNA expression decreased whereas GATA-3 mRNA expression increased significantly in patients with systemic lupus erythematosus.
Title: [Expression of transcription factors T-bet and GATA-3 in peripheral blood mononuclear cells from patients with systemic lupus erythematosus].
NZB treatment determines an accumulation of CD4+T-bet+, CD4+pSTAT3+ and CD8+T-bet+ T cells in the peripheral blood of natalizumab treated multiple sclerosis patients.
Title: CD4+T-bet+, CD4+pSTAT3+ and CD8+T-bet+ T cells accumulate in peripheral blood during NZB treatment.
The ratio of T-bet/GATA-3 can be used as an objective indicator of immune imbalance in patients with allergic asthma.
Title: Correlation between the ratio of T-bet/GATA-3 and the levels of IL-4 and IFN-γ in patients with allergic asthma.
These results are the first to identify T-bet expression and activity in a structural cell of the lung and may provide new insights into therapeutic targets for inflammatory airway disease.
Title: T-bet is induced by interferon-γ to mediate chemokine secretion and migration in human airway smooth muscle cells.
At the time point for rapid recall (6 h after stimulation), NF-kappaB, but not T-bet, is present in the nucleus of naive and memory CD4 T cells and exhibits a greater-fold upregulation in memory CD4 T cells.
Title: Transcriptional control of rapid recall by memory CD4 T cells.
The T-bet deficiency and the correlation of GATA-3 expression with the increase of IgE are characteristics of long-lasting asthma.
Title: FoxP3, GATA-3 and T-bet expression in elderly asthma.

Submit: New GeneRIF Correction See all (92)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Asthma, aspirin-induced, susceptibility to

MIM: 208550

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat acts as a co-stimulatory molecule that affects viral replication by modulating host immune response through induction of T-bet expression and IFN-gamma secretion	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:119027	BioGRID:107777	CREBBP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:119027	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western
BioGRID:119027	BioGRID:108895	GATA3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:119027	BioGRID:109467	HOXC11	BioGRID	PubMed	Two-hybrid
BioGRID:119027	BioGRID:112550	SP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:119027	BioGRID:121544	ZNF490	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
lymphocyte migration	IDA Inferred from Direct Assay more info	PubMed
multicellular organismal development	TAS Traceable Author Statement more info	PubMed
positive regulation of isotype switching to IgG isotypes	IEA Inferred from Electronic Annotation more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
regulation of immune response	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	TAS Traceable Author Statement more info	PubMed
response to virus	IEP Inferred from Expression Pattern more info

Component	Evidence Code	Pubs
neuronal cell body	IEA Inferred from Electronic Annotation more info
nucleus	NAS Non-traceable Author Statement more info

General protein information

Preferred Names: T-box transcription factor TBX21

Names: T-box transcription factor TBX21; T-box protein 21; T-box expressed in T cells; transcription factor TBLYM; T-cell-specific T-box transcription factor T-bet

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012166.1 RefSeqGene

Range

5001..17876

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_013351.1 → NP_037483.1 T-box transcription factor TBX21

Status: REVIEWED

Source sequence(s)

AF093098

Consensus CDS

CCDS11514.1

UniProtKB/Swiss-Prot

Q9UL17

Related

ENSP00000177694, ENST00000177694

Conserved Domains (1) summary

cd00182
Location:136 – 327
Blast Score: 713

TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p5 Primary Assembly

Range

45810610..45823485

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

41179683..41192556

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC015674.12 (50868..63743)	None
genomic	CH471109.2	EAW94804.1
genomic	GN337430.1	CAY39299.1
genomic	GN337449.1	CAY39301.1
mRNA	AF093098.1	AAF00055.1
mRNA	AF241243.2	AAF61243.1
mRNA	AK223634.1	BAD97354.1
mRNA	BC039739.2	AAH39739.1