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TNPO2 transportin 2 [ Homo sapiens (human) ]

Gene ID: 30000, updated on 8-May-2016
Official Symbol
TNPO2provided by HGNC
Official Full Name
transportin 2provided by HGNC
Primary source
HGNC:HGNC:19998
See related
Ensembl:ENSG00000105576 MIM:603002; Vega:OTTHUMG00000180333
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IPO3; TRN2; KPNB2B
Orthologs
Location:
19p13.2
Exon count:
28
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (12699194..12723996, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12810008..12834838, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372280 Neighboring gene F-box and WD repeat domain containing 9 Neighboring gene small nucleolar RNA, C/D box 41 Neighboring gene chromosome 19 open reading frame 43 Neighboring gene arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ12155

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Ran GTPase binding IEA
Inferred from Electronic Annotation
more info
 
nuclear localization sequence binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
protein import into nucleus, docking IBA
Inferred from Biological aspect of Ancestor
more info
 
protein import into nucleus, translocation IBA
Inferred from Biological aspect of Ancestor
more info
 
ribosomal protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
transportin-2
Names
importin 3
karyopherin beta 2b, transportin
karyopherin beta-2b
transportin 2 (importin 3, karyopherin beta 2b)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136195.1NP_001129667.1  transportin-2 isoform 2

    See identical proteins and their annotated locations for NP_001129667.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a short in-frame segment in the 3' coding region and has differences in the 5' UTR compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AB210011, BC072420, DC407313, F15550
    Consensus CDS
    CCDS45992.1
    UniProtKB/Swiss-Prot
    O14787
    UniProtKB/TrEMBL
    A0A024R7F7, Q4LE60
    Related
    ENSP00000465625, OTTHUMP00000264004, ENST00000588216, OTTHUMT00000450786
    Conserved Domains (4) summary
    COG5215
    Location:22756
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    cd00020
    Location:405506
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam03810
    Location:3699
    IBN_N; Importin-beta N-terminal domain
    pfam13513
    Location:227276
    HEAT_EZ; HEAT-like repeat
  2. NM_001136196.1NP_001129668.1  transportin-2 isoform 1

    See identical proteins and their annotated locations for NP_001129668.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC018761, AF019039, BC018314, BC072420, DA100622, DC377831, F15550
    Consensus CDS
    CCDS45991.1
    UniProtKB/Swiss-Prot
    O14787
    UniProtKB/TrEMBL
    Q05D48
    Related
    ENSP00000468434, OTTHUMP00000264003, ENST00000592287, OTTHUMT00000450785
    Conserved Domains (4) summary
    COG5215
    Location:22756
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    cd00020
    Location:405504
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam03810
    Location:3699
    IBN_N; Importin-beta N-terminal domain
    pfam13513
    Location:227276
    HEAT_EZ; HEAT-like repeat
  3. NM_013433.4NP_038461.2  transportin-2 isoform 2

    See identical proteins and their annotated locations for NP_038461.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a short in-frame segment in the 3' coding region and has differences in the 5' UTR compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    BC072420, DA808781, F15550
    Consensus CDS
    CCDS45992.1
    UniProtKB/Swiss-Prot
    O14787
    UniProtKB/TrEMBL
    A0A024R7F7, Q4LE60
    Related
    ENSP00000349321, OTTHUMP00000264001, ENST00000356861, OTTHUMT00000450782
    Conserved Domains (4) summary
    COG5215
    Location:22756
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    cd00020
    Location:405506
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam03810
    Location:3699
    IBN_N; Importin-beta N-terminal domain
    pfam13513
    Location:227276
    HEAT_EZ; HEAT-like repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    12699194..12723996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    12810514..12835309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)