Format

Send to:

Choose Destination

DPP7 dipeptidyl peptidase 7 [ Homo sapiens (human) ]

Gene ID: 29952, updated on 8-May-2016
Official Symbol
DPP7provided by HGNC
Official Full Name
dipeptidyl peptidase 7provided by HGNC
Primary source
HGNC:HGNC:14892
See related
Ensembl:ENSG00000176978 HPRD:07634; MIM:610537; Vega:OTTHUMG00000020977
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
QPP; DPP2; DPPII
Summary
The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008]
Orthologs
Location:
9q34.3
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (137110540..137117980, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (140004992..140009204, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene MAN1B1 antisense RNA 1 (head to head) Neighboring gene mannosidase alpha class 1B member 1 Neighboring gene uncharacterized LOC101930307 Neighboring gene glutamate ionotropic receptor NMDA type subunit 1 Neighboring gene uncharacterized LOC105376328 Neighboring gene microRNA 3621 Neighboring gene leucine rich repeat containing 26

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
serine-type carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
serine-type peptidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytoplasmic, membrane-bounded vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lysosome IEA
Inferred from Electronic Annotation
more info
 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
dipeptidyl peptidase 2
Names
DPP II
carboxytripeptidase
dipeptidyl aminopeptidase II
dipeptidyl arylamidase II
dipeptidyl peptidase II
dipeptidyl-peptidase II
quiescent cell proline dipeptidase
NP_037511.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013379.2NP_037511.2  dipeptidyl peptidase 2 preproprotein

    See identical proteins and their annotated locations for NP_037511.2

    Status: REVIEWED

    Source sequence(s)
    AF154502, AL533195, BC016961, BF342300, BX400716
    Consensus CDS
    CCDS7030.1
    UniProtKB/Swiss-Prot
    Q9UHL4
    Related
    ENSP00000360635, OTTHUMP00000022680, ENST00000371579, OTTHUMT00000055279
    Conserved Domains (1) summary
    cl19554
    Location:38465
    Peptidase_S28; Serine carboxypeptidase S28

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    137110540..137117980 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518600.1XP_011516902.1  

    Conserved Domains (1) summary
    cl19554
    Location:56457
    Peptidase_S28; Serine carboxypeptidase S28
  2. XM_006717083.2XP_006717146.1  

    Conserved Domains (1) summary
    cl19554
    Location:38449
    Peptidase_S28; Serine carboxypeptidase S28
  3. XM_005266075.2XP_005266132.1  

    Conserved Domains (1) summary
    cl19554
    Location:38538
    Peptidase_S28; Serine carboxypeptidase S28
  4. XM_011518601.1XP_011516903.1  

    Conserved Domains (1) summary
    cl19554
    Location:179417
    Peptidase_S28; Serine carboxypeptidase S28
  5. XM_011518599.1XP_011516901.1  

    Conserved Domains (1) summary
    cl19554
    Location:86487
    Peptidase_S28; Serine carboxypeptidase S28

RNA

  1. XR_929782.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    140153770..140157892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)