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C18orf8 chromosome 18 open reading frame 8 [ Homo sapiens (human) ]

Gene ID: 29919, updated on 8-May-2016
Official Symbol
C18orf8provided by HGNC
Official Full Name
chromosome 18 open reading frame 8provided by HGNC
Primary source
HGNC:HGNC:24326
See related
Ensembl:ENSG00000141452 HPRD:12693; Vega:OTTHUMG00000179239
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIC1; Mic-1; HsT2591
Summary
This gene encodes a colon cancer associated protein. [provided by RefSeq, Jan 2013]
Orthologs
Location:
18q11.2
Exon count:
20
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 18 NC_000018.10 (23503470..23531807)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (21083434..21113311)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 241 Neighboring gene RIO kinase 3 Neighboring gene NPC intracellular cholesterol transporter 1 Neighboring gene ankyrin repeat domain 29 Neighboring gene ribosomal protein S10 pseudogene 27

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ23453

Gene Ontology Provided by GOA

Component Evidence Code Pubs
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
uncharacterized protein C18orf8
Names
colon cancer-associated protein Mic1
macrophage inhibitory cytokine 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033119.1 RefSeqGene

    Range
    5001..33338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276342.1NP_001263271.1  uncharacterized protein C18orf8 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the 5' coding region and uses an alternate splice site in the 3' coding region, which results in a frameshift compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC010853, AC026634, AK295246, AK296230
    Consensus CDS
    CCDS74199.1
    UniProtKB/TrEMBL
    A0A087WZD4, B7Z2Y1, B7Z3Q1
    Related
    ENSP00000482573, ENST00000615148
    Conserved Domains (1) summary
    pfam07035
    Location:423510
    Mic1; Colon cancer-associated protein Mic1-like
  2. NM_001318707.1NP_001305636.1  uncharacterized protein C18orf8 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three exons in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC010853, AC026634, AK294169, BC008305
    UniProtKB/Swiss-Prot
    Q96DM3
    UniProtKB/TrEMBL
    B7Z201
    Conserved Domains (1) summary
    pfam07035
    Location:314480
    Mic1; Colon cancer-associated protein Mic1-like
  3. NM_001318708.1NP_001305637.1  uncharacterized protein C18orf8 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences, which result in the use of a downstream in-frame start codon and a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (4) has a shorter N-terminus and a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC010853, AC026634, AK295246, BC008305
    UniProtKB/Swiss-Prot
    Q96DM3
    UniProtKB/TrEMBL
    B7Z2Y1
    Conserved Domains (1) summary
    pfam07035
    Location:314401
    Mic1; Colon cancer-associated protein Mic1-like
  4. NM_001318709.1NP_001305638.1  uncharacterized protein C18orf8 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two consecutive in-frame exons in the 5' coding region. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC026634, AK296230, BC008305, DC383182
    UniProtKB/Swiss-Prot
    Q96DM3
    UniProtKB/TrEMBL
    B7Z3Q1, K7ENL9
    Conserved Domains (1) summary
    pfam07035
    Location:423589
    Mic1; Colon cancer-associated protein Mic1-like
  5. NM_013326.4NP_037458.3  uncharacterized protein C18orf8 isoform 1

    See identical proteins and their annotated locations for NP_037458.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC010853, AC026634, AK057192, AK294169
    Consensus CDS
    CCDS32803.1
    UniProtKB/Swiss-Prot
    Q96DM3
    UniProtKB/TrEMBL
    B7Z201
    Related
    ENSP00000269221, OTTHUMP00000260974, ENST00000269221, OTTHUMT00000445386
    Conserved Domains (1) summary
    pfam07035
    Location:471637
    Mic1; Colon cancer-associated protein Mic1-like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p2 Primary Assembly

    Range
    23503470..23531807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525939.1XP_011524241.1  

    Conserved Domains (1) summary
    pfam07035
    Location:314480
    Mic1; Colon cancer-associated protein Mic1-like
  2. XM_011525938.1XP_011524240.1  

    Related
    ENSP00000467007, OTTHUMP00000260976, ENST00000590868, OTTHUMT00000445389
    Conserved Domains (1) summary
    pfam07035
    Location:423589
    Mic1; Colon cancer-associated protein Mic1-like

RNA

  1. XR_935218.1 RNA Sequence

    Related
    ENST00000590870, OTTHUMT00000445392

Alternate CHM1_1.1

Genomic

  1. NC_018929.2 Alternate CHM1_1.1

    Range
    21010696..21039051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)