EEF2K eukaryotic elongation factor-2 kinase [Homo sapiens] - Gene

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Summary

Official Symbol: EEF2Kprovided by HGNC
Official Full Name: eukaryotic elongation factor-2 kinaseprovided by HGNC
Primary source: HGNC:24615
See related: Ensembl:ENSG00000103319; HPRD:07369; MIM:606968; Vega:OTTHUMG00000094771
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: eEF-2K; HSU93850; MGC45041
Summary: This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 16p12.2

Sequence :: Chromosome: 16; NC_000016.9 (22217592..22300066)

See EEF2K in Epigenomics, MapViewer

Chromosome 16 - NC_000016.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

highly conserved residues in the C-terminal tip of eEF2K are essential for the phosphorylation of eEF2
Title: Insights into the regulation of eukaryotic elongation factor 2 kinase and the interplay between its domains.
results suggest that the expression of eEF-2 kinase contributes to migration and invasion of human glioma cells by protecting them from anoikis.
Title: Expression of elongation factor-2 kinase contributes to anoikis resistance and invasion of human glioma cells.
activation of eEF-2 kinase-mediated autophagy plays a protective role for cancer cells under metabolic stress conditions
Title: Cytoprotective effect of the elongation factor-2 kinase-mediated autophagy in breast cancer cells subjected to growth factor inhibition.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
The target cells (HGC-27) expressed EF-2K and MHC-class I together with costimulatory molecules from heat stress. This antigen specific immune mechanism could have a prominent role in the pathogenesis of gastric ulcer.
Title: Immune reactions against elongation factor 2 kinase: specific pathogenesis of gastric ulcer from Helicobacter pylori infection.
These data closely match the control of Ser359 phosphorylation and indicate that cdc2 may be regulated by mTORC1.
Title: cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner.
AMPK and eEF2 kinase may provide a key link between cellular energy status and the inhibition of protein synthesis, a major consumer of metabolic energy
Title: Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398.
our results suggest that anisomycin or TNF-alpha inhibit eEF2 kinase via the phosphorylation of Ser-359.
Title: Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways.
Levels of p-eEF2K were significantly increased, and total eEF2 significantly decreased in Alzheimer disease
Title: Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain.
Results show that eukaryotic elongation factor 2 kinase is a target for mTOR signaling independently of previously known downstream components of the pathway.
Title: A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin.

Submit: New GeneRIF Correction See all (11)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
O00418	Q15759	MAPK11	HPRD	PubMed
O00418	P53778	MAPK12	HPRD	PubMed
O00418	O15264	MAPK13	HPRD	PubMed
O00418	Q16539	MAPK14	HPRD	PubMed
O00418	P45983	MAPK8	HPRD	PubMed
O00418	P45984	MAPK9	HPRD	PubMed
O00418	P49137	MAPKAPK2	HPRD	PubMed
O00418	Q16644	MAPKAPK3	HPRD	PubMed
O00418	Q8IW41	MAPKAPK5	HPRD	PubMed
O00418	Q13131	PRKAA1	HPRD	PubMed
O00418	P54646	PRKAA2	HPRD	PubMed
O00418	P17612	PRKACA	HPRD	PubMed
O00418	Q15418	RPS6KA1	HPRD	PubMed
O00418	P23443	RPS6KB1	HPRD	PubMed
O00418	Q9UBS0	RPS6KB2	HPRD	PubMed
BioGRID:118953	BioGRID:112109	RPS6KA1	BioGRID	PubMed	Reconstituted Complex
BioGRID:118953	BioGRID:112112	RPS6KB1	BioGRID	PubMed	Reconstituted Complex
BioGRID:118953	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
binding	IEA Inferred from Electronic Annotation more info
calcium ion binding	IEA Inferred from Electronic Annotation more info
calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
elongation factor-2 kinase activity	IDA Inferred from Direct Assay more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein kinase activity	TAS Traceable Author Statement more info	PubMed
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
translation factor activity, nucleic acid binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
insulin receptor signaling pathway	TAS Traceable Author Statement more info
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	TAS Traceable Author Statement more info	PubMed
regulation of protein autophosphorylation	IEA Inferred from Electronic Annotation more info
translational elongation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	TAS Traceable Author Statement more info	PubMed
cytosol	TAS Traceable Author Statement more info

General protein information

Preferred Names: eukaryotic elongation factor 2 kinase

Names: eukaryotic elongation factor 2 kinase; eEF-2 kinase; elongation factor-2 kinase; eukaroytic elongation factor 2 kinase; calmodulin-dependent protein kinase III; calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase

NP_037434.1

EC 2.7.11.20

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013302.3 → NP_037434.1 eukaryotic elongation factor 2 kinase

Status: REVIEWED

Source sequence(s)

AC009034, AW675420, CA397138, DA556486, DA735877, U93850

Consensus CDS

CCDS10604.1

UniProtKB/Swiss-Prot

O00418

Related

ENSP00000263026, OTTHUMP00000119998, ENST00000263026, OTTHUMT00000211580

Conserved Domains (2) summary

COG0790
Location:496 – 713
Blast Score: 106

COG0790; FOG: TPR repeat, SEL1 subfamily [General function prediction only]

cl03728
Location:121 – 318
Blast Score: 770

Alpha_kinase; Alpha-kinase family

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000016.9 Reference GRCh37.p5 Primary Assembly

Range

22217592..22300066

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000148.1 Alternate HuRef

Range

20462336..20544660

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC009034.10 (70225..152536)	None
genomic	CH471249.1	EAW50604.1
mRNA	AK022569.1	None
mRNA	AK308757.1	None
mRNA	AW675420.1	None
mRNA	BC032665.1	AAH32665.1
mRNA	CA397138.1	None
mRNA	DA556486.1	None
mRNA	DA735877.1	None
mRNA	U93850.1	AAB58270.1
other-genetic	DQ890896.2	ABM81822.1
other-genetic	DQ894050.2	ABM84976.1