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EEF2K eukaryotic elongation factor-2 kinase [ Homo sapiens (human) ]

Gene ID: 29904, updated on 19-Jul-2014
Official Symbol
EEF2Kprovided by HGNC
Official Full Name
eukaryotic elongation factor-2 kinaseprovided by HGNC
Primary source
HGNC:24615
See related
HPRD:07369; MIM:606968
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
eEF-2K; HSU93850
Summary
This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]
See EEF2K in Epigenomics, MapViewer
Location:
16p12.2
Exon count :
18
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 16 NC_000016.10 (22206271..22288745)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (22217592..22300066)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene von Willebrand factor A domain containing 3A Neighboring gene transfer RNA-Leu (TAG) 3-1 Neighboring gene transfer RNA-Leu (AAG) 2-2 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide E (80kD)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
elongation factor-2 kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
translation factor activity, nucleic acid binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
insulin receptor signaling pathway TAS
Traceable Author Statement
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
translational elongation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
Preferred Names
eukaryotic elongation factor 2 kinase
Names
eukaryotic elongation factor 2 kinase
eEF-2 kinase
elongation factor-2 kinase
eukaroytic elongation factor 2 kinase
calmodulin-dependent protein kinase III
calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase
calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase
NP_037434.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013302.3NP_037434.1  eukaryotic elongation factor 2 kinase

    See proteins identical to NP_037434.1

    Status: REVIEWED

    Source sequence(s)
    AC009034, AW675420, CA397138, DA556486, DA735877, U93850
    Consensus CDS
    CCDS10604.1
    UniProtKB/Swiss-Prot
    O00418
    Conserved Domains (2) summary
    smart00811
    Location:121318
    Blast Score: 774
    Alpha_kinase; Alpha-kinase family
    COG0790
    Location:533713
    Blast Score: 105
    COG0790; FOG: TPR repeat, SEL1 subfamily [General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000016.10 

    Range
    22206271..22288745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000148.1 

    Range
    20462336..20544660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 

    Range
    22091272..22173735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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