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Dld dihydrolipoamide dehydrogenase [ Rattus norvegicus (Norway rat) ]

Gene ID: 298942, updated on 8-May-2016
Official Symbol
Dldprovided by RGD
Official Full Name
dihydrolipoamide dehydrogenaseprovided by RGD
Primary source
RGD:735073
See related
Ensembl:ENSRNOG00000006364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. A similar protein in human, mouse, and pig has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, the protein can function as a protease. [provided by RefSeq, Jan 2014]
Orthologs
Location:
6q16
Exon count:
15
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (50597677..50618694, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (59273427..59293925, complement)

Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene serine palmitoyltransferase small subunit A pseudogene Neighboring gene laminin subunit beta 1 Neighboring gene solute carrier family 26 member 3 Neighboring gene Cbl proto-oncogene like 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NAD binding IDA
Inferred from Direct Assay
more info
PubMed 
dihydrolipoyl dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
dihydrolipoyl dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
lipoamide binding IDA
Inferred from Direct Assay
more info
PubMed 
pyruvate dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to pyruvate dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
2-oxoglutarate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acetyl-CoA biosynthetic process from pyruvate IDA
Inferred from Direct Assay
more info
PubMed 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
dihydrolipoamide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
gastrulation IEA
Inferred from Electronic Annotation
more info
 
gastrulation ISO
Inferred from Sequence Orthology
more info
 
lipoate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial electron transport, NADH to ubiquinone IEA
Inferred from Electronic Annotation
more info
 
mitochondrial electron transport, NADH to ubiquinone ISO
Inferred from Sequence Orthology
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
regulation of membrane potential IEA
Inferred from Electronic Annotation
more info
 
regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
sperm capacitation IEA
Inferred from Electronic Annotation
more info
 
sperm capacitation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
acrosomal matrix IEA
Inferred from Electronic Annotation
more info
 
acrosomal matrix ISO
Inferred from Sequence Orthology
more info
 
cilium IEA
Inferred from Electronic Annotation
more info
 
cilium ISO
Inferred from Sequence Orthology
more info
 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
myelin sheath IEA
Inferred from Electronic Annotation
more info
 
myelin sheath ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
oxoglutarate dehydrogenase complex IDA
Inferred from Direct Assay
more info
PubMed 
pyruvate dehydrogenase complex IDA
Inferred from Direct Assay
more info
PubMed 
pyruvate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
dihydrolipoyl dehydrogenase, mitochondrial
Names
dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex)
NP_955417.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199385.2NP_955417.1  dihydrolipoyl dehydrogenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_955417.1

    Status: VALIDATED

    Source sequence(s)
    FM044626, FM046215, FM087994, FM093110, FM100976, FM139628
    UniProtKB/Swiss-Prot
    Q6P6R2
    Related
    ENSRNOP00000008980, ENSRNOT00000008980
    Conserved Domains (4) summary
    pfam00070
    Location:215288
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:389497
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
    TIGR01350
    Location:43508
    lipoamide_DH; dihydrolipoamide dehydrogenase
    cl21454
    Location:4379
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

    Range
    50597677..50618694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764590.1XP_008762812.1  

    Conserved Domains (4) summary
    pfam00070
    Location:213286
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:387495
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
    TIGR01350
    Location:41506
    lipoamide_DH; dihydrolipoamide dehydrogenase
    cl21454
    Location:4177
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

Alternate Rn_Celera

Genomic

  1. AC_000074.1 Alternate Rn_Celera

    Range
    47106161..47126575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)