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STRN4 striatin 4 [ Homo sapiens (human) ]

Gene ID: 29888, updated on 14-May-2016
Official Symbol
STRN4provided by HGNC
Official Full Name
striatin 4provided by HGNC
Primary source
HGNC:HGNC:15721
See related
Ensembl:ENSG00000090372 HPRD:18125; MIM:614767; Vega:OTTHUMG00000183432
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZIN; PPP2R6C; zinedin
Orthologs
Location:
19q13.2
Exon count:
22
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (46719509..46746475, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47222768..47250251, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene dishevelled binding antagonist of beta catenin 3 Neighboring gene DACT3 antisense RNA 1 Neighboring gene protein kinase D2 Neighboring gene microRNA 320e Neighboring gene fukutin related protein Neighboring gene solute carrier family 1 member 5 Neighboring gene heterogeneous nuclear ribonucleoprotein M pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ35594

Gene Ontology Provided by GOA

Function Evidence Code Pubs
armadillo repeat domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
calmodulin binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase 2A binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
striatin-4
Names
protein phosphatase 2 regulatory subunit B'''gamma
striatin, calmodulin binding protein 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039877.1NP_001034966.1  striatin-4 isoform 2

    See identical proteins and their annotated locations for NP_001034966.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AB209003, AF212940, DA510367
    Consensus CDS
    CCDS42581.1
    UniProtKB/Swiss-Prot
    Q9NRL3
    UniProtKB/TrEMBL
    Q59GV6
    Related
    ENSP00000375777, OTTHUMP00000271669, ENST00000391910, OTTHUMT00000466606
    Conserved Domains (3) summary
    COG2319
    Location:423753
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:437759
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:64197
    Striatin; Striatin family
  2. NM_013403.2NP_037535.2  striatin-4 isoform 1

    See identical proteins and their annotated locations for NP_037535.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate splice site in the central coding region, compared to variant 2. The resulting isoform (1) lacks an internal 7-aa segment, compared to isoform 2.
    Source sequence(s)
    AF212940, BC034604, DA510367
    Consensus CDS
    CCDS12690.1
    UniProtKB/Swiss-Prot
    Q9NRL3
    Related
    ENSP00000263280, OTTHUMP00000271670, ENST00000263280, OTTHUMT00000466607
    Conserved Domains (3) summary
    COG2319
    Location:416746
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:430752
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:64197
    Striatin; Striatin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    46719509..46746475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723172.2XP_006723235.1  

    Conserved Domains (3) summary
    COG2319
    Location:431761
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:445767
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:64212
    Striatin; Striatin family
  2. XM_006723171.2XP_006723234.1  

    Conserved Domains (3) summary
    COG2319
    Location:438768
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:452774
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:64212
    Striatin; Striatin family
  3. XM_011526878.1XP_011525180.1  

    Conserved Domains (1) summary
    pfam08232
    Location:64212
    Striatin; Striatin family
  4. XM_011526876.1XP_011525178.1  

    Conserved Domains (3) summary
    COG2319
    Location:384714
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:398720
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:41158
    Striatin; Striatin family
  5. XM_011526877.1XP_011525179.1  

    Conserved Domains (3) summary
    COG2319
    Location:369699
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:383705
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:41143
    Striatin; Striatin family
  6. XM_006723174.2XP_006723237.1  

    Related
    ENSP00000440901, OTTHUMP00000271671, ENST00000539396, OTTHUMT00000466610
    Conserved Domains (3) summary
    COG2319
    Location:304634
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:318640
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:178
    Striatin; Striatin family
  7. XM_011526879.1XP_011525181.1  

    See identical proteins and their annotated locations for XP_011525181.1

    UniProtKB/TrEMBL
    B3KPF6
    Conserved Domains (2) summary
    COG2319
    Location:45358
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:42364
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    47224668..47251617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)