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SNX8 sorting nexin 8 [ Homo sapiens (human) ]

Gene ID: 29886, updated on 26-May-2016
Official Symbol
SNX8provided by HGNC
Official Full Name
sorting nexin 8provided by HGNC
Primary source
HGNC:HGNC:14972
See related
Ensembl:ENSG00000106266 HPRD:11592; MIM:614905; Vega:OTTHUMG00000151512
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Mvp1
Orthologs
Location:
7p22.3
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (2251770..2314475, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (2291405..2354099, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene mitochondrial rRNA methyltransferase 2 Neighboring gene nudix hydrolase 1 Neighboring gene microRNA 6836 Neighboring gene eukaryotic translation initiation factor 3 subunit B Neighboring gene kinesin family member pseudogene

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
NHGRI GWA Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • DKFZp761E1721

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylinositol binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
early endosome to Golgi transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle organization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
colocalizes_with retromer complex IDA
Inferred from Direct Assay
more info
PubMed 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013321.3NP_037453.1  sorting nexin-8

    See identical proteins and their annotated locations for NP_037453.1

    Status: VALIDATED

    Source sequence(s)
    AC004971, AL713633, BC021565, BP320122
    Consensus CDS
    CCDS5331.1
    UniProtKB/Swiss-Prot
    Q9Y5X2
    Related
    ENSP00000222990, OTTHUMP00000200137, ENST00000222990, OTTHUMT00000322949
    Conserved Domains (2) summary
    cd06866
    Location:75178
    PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
    cd07597
    Location:195440
    BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    2251770..2314475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515329.1XP_011513631.1  

    Conserved Domains (2) summary
    cd06866
    Location:67170
    PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
    cd07597
    Location:187432
    BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8
  2. XM_011515330.1XP_011513632.1  

    Conserved Domains (2) summary
    cd06866
    Location:61164
    PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
    cd07597
    Location:181426
    BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    2291011..2353701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)