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CNOT7 CCR4-NOT transcription complex subunit 7 [ Homo sapiens (human) ]

Gene ID: 29883, updated on 26-May-2016
Official Symbol
CNOT7provided by HGNC
Official Full Name
CCR4-NOT transcription complex subunit 7provided by HGNC
Primary source
HGNC:HGNC:14101
See related
Ensembl:ENSG00000198791 MIM:604913; Vega:OTTHUMG00000096971
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAF1; CAF-1; Caf1a; hCAF-1
Summary
The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]
Orthologs
Location:
8p22-p21.3
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (17226030..17246878, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (17086737..17104387, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L9 pseudogene 20 Neighboring gene zinc finger DHHC-type containing 2 Neighboring gene VPS37A, ESCRT-I subunit Neighboring gene myotubularin related protein 7 Neighboring gene uncharacterized LOC102724838

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Deadenylation of mRNA, organism-specific biosystem (from REACTOME)
    Deadenylation of mRNA, organism-specific biosystemDeadenylation of mRNA proceeds in two steps. According to current models, in the first step the poly(A) tail is shortened from about 200 adenosine residues to about 80 residues by the PAN2-PAN3 compl...
  • Deadenylation-dependent mRNA decay, organism-specific biosystem (from REACTOME)
    Deadenylation-dependent mRNA decay, organism-specific biosystemAfter undergoing rounds of translation, mRNA is normally destroyed by the deadenylation-dependent pathway. Though the trigger is unclear, deadenylation likely proceeds in two steps: one catalyzed by...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • RNA degradation, organism-specific biosystem (from KEGG)
    RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • RNA degradation, conserved biosystem (from KEGG)
    RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • TP53 Regulates Transcription of Cell Cycle Genes, organism-specific biosystem (from REACTOME)
    TP53 Regulates Transcription of Cell Cycle Genes, organism-specific biosystemUnder a variety of stress conditions, TP53 (p53), stabilized by stress-induced phosphorylation at least on S15 and S20 serine residues, can induce the transcription of genes involved in cell cycle ar...
  • TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, organism-specific biosystem (from REACTOME)
    TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, organism-specific biosystemBTG2 is induced by TP53, leading to cessation of cellular proliferation (Rouault et al. 1996, Duriez et al. 2002). BTG2 binds to the CCR4-NOT complex and promotes mRNA deadenylation activity of this ...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-5'-exoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
exoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
poly(A)-specific ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signal transducer activity TAS
Traceable Author Statement
more info
PubMed 
transcription factor activity, sequence-specific DNA binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
 
RNA phosphodiester bond hydrolysis, exonucleolytic IEA
Inferred from Electronic Annotation
more info
 
carbohydrate metabolic process TAS
Traceable Author Statement
more info
PubMed 
cytoplasmic mRNA processing body assembly IEA
Inferred from Electronic Annotation
more info
 
deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
Inferred from Electronic Annotation
more info
 
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
PubMed 
gene silencing by RNA ISS
Inferred from Sequence or Structural Similarity
more info
 
gene silencing by miRNA TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear-transcribed mRNA poly(A) tail shortening TAS
Traceable Author Statement
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
CCR4-NOT complex IDA
Inferred from Direct Assay
more info
PubMed 
CCR4-NOT complex NAS
Non-traceable Author Statement
more info
PubMed 
cytoplasmic mRNA processing body ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
CCR4-NOT transcription complex subunit 7
Names
BTG1-binding factor 1
CCR4-associated factor 1
carbon catabolite repressor protein (CCR4)-associative factor 1
NP_037486.2
NP_473367.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322087.1NP_001309016.1  CCR4-NOT transcription complex subunit 7 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 all encode isoform 2.
    Source sequence(s)
    AW448990, BC070187, BI094365, BI458088, DA695885, DA752620
    Conserved Domains (1) summary
    pfam04857
    Location:13240
    CAF1; CAF1 family ribonuclease
  2. NM_001322088.1NP_001309017.1  CCR4-NOT transcription complex subunit 7 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, and contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 all encode isoform 2.
    Source sequence(s)
    AL833642, AW448990, BC070187, BI094365, BI552176, DA695885
    Conserved Domains (1) summary
    pfam04857
    Location:13240
    CAF1; CAF1 family ribonuclease
  3. NM_001322089.1NP_001309018.1  CCR4-NOT transcription complex subunit 7 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, and contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 all encode isoform 2.
    Source sequence(s)
    AC091050, AW448990, BC070187, BI094365, BI464507, DA695885, HY002876
    Conserved Domains (1) summary
    pfam04857
    Location:13240
    CAF1; CAF1 family ribonuclease
  4. NM_001322090.1NP_001309019.1  CCR4-NOT transcription complex subunit 7 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 6, 7 and 8 all encode isoform 1.
    Source sequence(s)
    BC007315, BC070187, BI458088, DA752620
    Conserved Domains (1) summary
    pfam04857
    Location:13240
    CAF1; CAF1 family ribonuclease
  5. NM_001322091.1NP_001309020.1  CCR4-NOT transcription complex subunit 7 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 6, 7 and 8 all encode isoform 1.
    Source sequence(s)
    AL833642, BC007315, BC070187, BI552176
    Conserved Domains (1) summary
    pfam04857
    Location:13240
    CAF1; CAF1 family ribonuclease
  6. NM_001322092.1NP_001309021.1  CCR4-NOT transcription complex subunit 7 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1. Variants 1, 6, 7 and 8 all encode isoform 1.
    Source sequence(s)
    AL833642, BC007315, BC070187, BI458088, BI552176
    Conserved Domains (1) summary
    pfam04857
    Location:13240
    CAF1; CAF1 family ribonuclease
  7. NM_001322093.1NP_001309022.1  CCR4-NOT transcription complex subunit 7 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) contains an additional in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is longer than isoform 1.
    Source sequence(s)
    AC091050, BC007315, BC070187, BI464507, DA752620
    Conserved Domains (1) summary
    pfam04857
    Location:13262
    CAF1; CAF1 family ribonuclease
  8. NM_001322094.1NP_001309023.1  CCR4-NOT transcription complex subunit 7 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternate splice site in the 3' terminal exon and thus contains an alternate 3' coding region, compared to variant 1. The encoded isoform (4) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AL528251, BC007315, BC070187, DA752620
    Conserved Domains (1) summary
    pfam04857
    Location:13240
    CAF1; CAF1 family ribonuclease
  9. NM_001322095.1NP_001309024.1  CCR4-NOT transcription complex subunit 7 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) contains an additional exon and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) is shorter at the N-terminus, compared to isoform 1. Variants 11, 12 and 13 all encode isoform 5.
    Source sequence(s)
    BC007315, BC070187, DA508565, DA752620
    Conserved Domains (1) summary
    cl10012
    Location:2198
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
  10. NM_001322096.1NP_001309025.1  CCR4-NOT transcription complex subunit 7 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) contains an additional exon and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) is shorter at the N-terminus, compared to isoform 1. Variants 11, 12 and 13 all encode isoform 5.
    Source sequence(s)
    BC007315, BC070187, DA720240, DA752620
    Conserved Domains (1) summary
    cl10012
    Location:2198
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
  11. NM_001322097.1NP_001309026.1  CCR4-NOT transcription complex subunit 7 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) contains alternate 5' exon structure and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) is shorter at the N-terminus, compared to isoform 1. Variants 11, 12 and 13 all encode isoform 5.
    Source sequence(s)
    AL833642, BC007315, BC070187, BI552176, DA720240
    Conserved Domains (1) summary
    cl10012
    Location:2198
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
  12. NM_001322098.1NP_001309027.1  CCR4-NOT transcription complex subunit 7 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) contains an additional exon and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, and it also contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (6) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1. Variants 14, 15 and 16 all encode isoform 6.
    Source sequence(s)
    AW448990, BC070187, BI094365, DA508565, DA695885, DA752620
    Conserved Domains (1) summary
    pfam04857
    Location:1159
    CAF1; CAF1 family ribonuclease
  13. NM_001322099.1NP_001309028.1  CCR4-NOT transcription complex subunit 7 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) contains an additional exon and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, and it also contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (6) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1. Variants 14, 15 and 16 all encode isoform 6.
    Source sequence(s)
    AW448990, BC070187, BI094365, DA695885, DA720240, DA752620
    Conserved Domains (1) summary
    pfam04857
    Location:1159
    CAF1; CAF1 family ribonuclease
  14. NM_001322100.1NP_001309029.1  CCR4-NOT transcription complex subunit 7 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) contains alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, and it also contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (6) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1. Variants 14, 15 and 16 all encode isoform 6.
    Source sequence(s)
    AW448990, BC070187, BI094365, BI458088, BI552176, DA508565, DA695885
    Conserved Domains (1) summary
    pfam04857
    Location:1159
    CAF1; CAF1 family ribonuclease
  15. NM_013354.6NP_037486.2  CCR4-NOT transcription complex subunit 7 isoform 1

    See identical proteins and their annotated locations for NP_037486.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 6, 7 and 8 all encode isoform 1.
    Source sequence(s)
    BC007315, BC070187, DA752620
    Consensus CDS
    CCDS6000.2
    UniProtKB/Swiss-Prot
    Q9UIV1
    Related
    ENSP00000355279, OTTHUMP00000122444, ENST00000361272, OTTHUMT00000214038
    Conserved Domains (1) summary
    pfam04857
    Location:13240
    CAF1; CAF1 family ribonuclease
  16. NM_054026.3NP_473367.2  CCR4-NOT transcription complex subunit 7 isoform 2

    See identical proteins and their annotated locations for NP_473367.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 all encode isoform 2.
    Source sequence(s)
    AW448990, BC070187, BI094365, DA695885, DA752620
    Consensus CDS
    CCDS55202.1
    UniProtKB/Swiss-Prot
    Q9UIV1
    Related
    ENSP00000429093, OTTHUMP00000225203, ENST00000523917, OTTHUMT00000376075
    Conserved Domains (1) summary
    pfam04857
    Location:13240
    CAF1; CAF1 family ribonuclease

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    17226030..17246878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544511.1XP_011542813.1  

    UniProtKB/Swiss-Prot
    Q9UIV1
    Conserved Domains (1) summary
    pfam04857
    Location:13240
    CAF1; CAF1 family ribonuclease
  2. XM_005273481.2XP_005273538.1  

    See identical proteins and their annotated locations for XP_005273538.1

    UniProtKB/Swiss-Prot
    Q9UIV1
    Conserved Domains (1) summary
    pfam04857
    Location:13240
    CAF1; CAF1 family ribonuclease

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    17288194..17305840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)