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ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase [ Homo sapiens (human) ]

Gene ID: 29880, updated on 8-May-2016
Official Symbol
ALG5provided by HGNC
Official Full Name
ALG5, dolichyl-phosphate beta-glucosyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:20266
See related
Ensembl:ENSG00000120697 HPRD:05193; MIM:604565; Vega:OTTHUMG00000016741
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
bA421P11.2
Summary
This gene encodes a member of the glycosyltransferase 2 family. The encoded protein participates in glucosylation of the oligomannose core in N-linked glycosylation of proteins. The addition of glucose residues to the oligomannose core is necessary to ensure substrate recognition, and therefore, effectual transfer of the oligomannose core to the nascent glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Orthologs
Location:
13q13.3
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 13 NC_000013.11 (36949770..36999367, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (37523907..37573504, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 pseudogene 28 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 5 Neighboring gene exosome component 8 Neighboring gene uncharacterized LOC105370165 Neighboring gene SPT20 homolog, SAGA complex component

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dolichyl-phosphate beta-D-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
dolichyl-phosphate beta-glucosyltransferase activity TAS
Traceable Author Statement
more info
 
dolichyl-phosphate-mannose-protein mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
oligosaccharyl transferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
determination of left/right symmetry IEA
Inferred from Electronic Annotation
more info
 
dolichol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
protein N-linked glycosylation via asparagine TAS
Traceable Author Statement
more info
 
protein O-linked mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
protein glycosylation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
dolichyl-phosphate beta-glucosyltransferase
Names
Alg5, S. cerevisiae, homolog of
asparagine-linked glycosylation 5 homolog (S. cerevisiae, dolichyl-phosphate beta-glucosyltransferase)
asparagine-linked glycosylation 5 homolog (yeast, dolichyl-phosphate beta-glucosyltransferase)
asparagine-linked glycosylation 5, dolichyl-phosphate beta-glucosyltransferase homolog
asparagine-linked glycosylation protein 5 homolog
dolP-glucosyltransferase
dolichyl phosphate glucosyltransferase
NP_001135836.1
NP_037470.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142364.1NP_001135836.1  dolichyl-phosphate beta-glucosyltransferase isoform 2

    See identical proteins and their annotated locations for NP_001135836.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter than isoform 1.
    Source sequence(s)
    AK299085, BP246765, BU739112
    Consensus CDS
    CCDS45033.1
    UniProtKB/Swiss-Prot
    Q9Y673
    Related
    ENSP00000390533, ENST00000443765
    Conserved Domains (1) summary
    cd04188
    Location:69259
    DPG_synthase; DPG_synthase is involved in protein N-linked glycosylation
  2. NM_013338.4NP_037470.1  dolichyl-phosphate beta-glucosyltransferase isoform 1

    See identical proteins and their annotated locations for NP_037470.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC012531, BP246765, BU739112
    Consensus CDS
    CCDS9361.1
    UniProtKB/Swiss-Prot
    Q9Y673
    Related
    ENSP00000239891, OTTHUMP00000018263, ENST00000239891, OTTHUMT00000044528
    Conserved Domains (1) summary
    cd04188
    Location:69289
    DPG_synthase; DPG_synthase is involved in protein N-linked glycosylation

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p2 Primary Assembly

    Range
    36949770..36999367 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266362.3XP_005266419.1  

    Conserved Domains (1) summary
    cd04188
    Location:69251
    DPG_synthase; DPG_synthase is involved in protein N-linked glycosylation
  2. XM_011535054.1XP_011533356.1  

    See identical proteins and their annotated locations for XP_011533356.1

    UniProtKB/TrEMBL
    B4DR67
    Conserved Domains (1) summary
    cl11394
    Location:69207
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

Alternate CHM1_1.1

Genomic

  1. NC_018924.2 Alternate CHM1_1.1

    Range
    37491436..37541055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)