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Tmem50a transmembrane protein 50A [ Rattus norvegicus (Norway rat) ]

Gene ID: 298552, updated on 5-Mar-2024

Summary

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Official Symbol
Tmem50aprovided by RGD
Official Full Name
transmembrane protein 50Aprovided by RGD
Primary source
RGD:1305638
See related
AllianceGenome:RGD:1305638
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305638
Summary
Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway. Predicted to be located in endoplasmic reticulum; glial cell projection; and neuronal cell body. Orthologous to human TMEM50A (transmembrane protein 50A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 381.8), Thymus (RPKM 366.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmem50a in Genome Data Viewer
Location:
5q36
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (152407352..152422539, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (147123670..147138859, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (153233965..153252006, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene macoilin 1 Neighboring gene uncharacterized LOC134487008 Neighboring gene Rh blood group, D antigen Neighboring gene arginine and serine rich protein 1 Neighboring gene SYF2 pre-mRNA-splicing factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Entire sequence of a mouse chromosomal segment containing the gene Rhced and a comparative analysis of the homologous human sequence. Kumada M, et al. Gene, 2002 Oct 16. PMID 12459264
  2. Transmembrane protein 50b (C21orf4), a candidate for Down syndrome neurophenotypes, encodes an intracellular membrane protein expressed in the rodent brain. Moldrich RX, et al. Neuroscience, 2008 Jul 17. PMID 18541381
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in glial cell projection ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 50A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127525.1 → NP_001120997.1  transmembrane protein 50A

    See identical proteins and their annotated locations for NP_001120997.1

    Status: PROVISIONAL

    Source sequence(s)
    BC161895
    UniProtKB/TrEMBL
    A6IT39, B1WBU7, E9PSZ2
    Conserved Domains (1) summary
    pfam05255
    Location:8 → 156
    UPF0220; uncharacterized protein family (UPF0220)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    152407352..152422539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109640.2 → XP_038965568.1  transmembrane protein 50A isoform X1

    Conserved Domains (1) summary
    pfam05255
    Location:7 → 112
    UPF0220; Uncharacterized protein family (UPF0220)

  2. XM_063287454.1 → XP_063143524.1  transmembrane protein 50A isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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