My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) [ Homo sapiens ]

    Gene ID: 29844, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    TFPTprovided by HGNC
    Official Full Name
    TCF3 (E2A) fusion partner (in childhood Leukemia)provided by HGNC
    Primary source
    HGNC:13630
    See related
    Ensembl:ENSG00000105619; HPRD:10266; MIM:609519; Vega:OTTHUMG00000065906
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FB1; amida; INO80F
    Help top of page

    Genomic context

    Location :
    19q13
    Sequence :
    Chromosome: 19; NC_000019.9 (54610320..54619055, complement)
    See TFPT in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene osteoclast associated, immunoglobulin-like receptor Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa Neighboring gene PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) Neighboring gene CCR4-NOT transcription complex, subunit 3 Neighboring gene leukocyte receptor cluster (LRC) member 1 Neighboring gene transmembrane channel-like 4

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. Chen L, et al. J Biol Chem, 2011 Apr 1. PMID 21303910.
    2. Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
    3. System-wide changes to SUMO modifications in response to heat shock. Golebiowski F, et al. Sci Signal, 2009 May 26. PMID 19471022.
    4. YY1 functions with INO80 to activate transcription. Cai Y, et al. Nat Struct Mol Biol, 2007 Sep. PMID 17721549.
    5. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Jeronimo C, et al. Mol Cell, 2007 Jul 20. PMID 17643375.

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. FB1 is an important binding partner and a functional regulator of U19/EAF2, EAF1, and/or ELL.
      Title: FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity.
    2. Although p53 is a main regulator of apoptosis in mammalian cells, the Tfpt induced apoptosis appears p53-independent.
      Title: Apoptosis promoted by up-regulation of TFPT (TCF3 fusion partner) appears p53 independent, cell type restricted and cell density influenced.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P0C1Z6 Q96JC9 EAF1    HPRD  PubMed  
    P0C1Z6 Q96CJ1 EAF2    HPRD  PubMed  
    P0C1Z6 P55199 ELL    HPRD  PubMed  
    P0C1Z6 O60936 NOL3    HPRD  PubMed  
    P0C1Z6 Q96IZ0 PAWR    HPRD  PubMed  
    P0C1Z6 O15483 RUNDC3A    HPRD  PubMed  
    P0C1Z6 P15923 TCF3    HPRD  PubMed  
    P0C1Z6 P06753 TPM3    HPRD  PubMed  
    BioGRID:118931 BioGRID:106601 ACTL6A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118931 BioGRID:122993 ACTR5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118931 BioGRID:125062 ACTR8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118931 BioGRID:124514 EAF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:118931 BioGRID:120943 EAF2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:118931 BioGRID:113828 ELL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:118931 BioGRID:120076 INO80    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118931 BioGRID:123646 INO80B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118931 BioGRID:125928 INO80C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118931 BioGRID:120238 INO80D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118931 BioGRID:129701 INO80E    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118931 BioGRID:115710 MCRS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118931 BioGRID:110864 NFRKB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118931 BioGRID:116106 RUNDC3A    BioGRID  PubMed Two-hybrid 
    BioGRID:118931 BioGRID:114166 RUVBL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118931 BioGRID:116067 RUVBL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118931 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118931 BioGRID:118931 TFPT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118931 BioGRID:113023 TPM3    BioGRID  PubMed Two-hybrid 
    BioGRID:118931 BioGRID:119509 UCHL5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118931 BioGRID:113360 YY1    BioGRID  PubMed Affinity Capture-MS 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    induction of apoptosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Ino80 complex IDA
    Inferred from Direct Assay
    more info
    		  
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    TCF3 fusion partner
    Names
    TCF3 fusion partner
    INO80 complex subunit F
    amida, partner of the E2A
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013342.3 → NP_037474.1  TCF3 fusion partner

      Status: VALIDATED

      Source sequence(s)
      AF052052, BI820344, BQ027375
      Consensus CDS
      CCDS12878.1
      UniProtKB/Swiss-Prot
      P0C1Z6
      Related
      ENSP00000375639, OTTHUMP00000071104, ENST00000391759, OTTHUMT00000141215

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      54610320..54619055, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 PATCHES

    Genomic

    1. NW_003571054.1 Reference GRCh37.p5 PATCHES

      Range
      81433..90168, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 PATCHES

    Genomic

    1. NW_003571055.1 Reference GRCh37.p5 PATCHES

      Range
      81433..90168, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 PATCHES

    Genomic

    1. NW_003571056.1 Reference GRCh37.p5 PATCHES

      Range
      81433..90168, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 PATCHES

    Genomic

    1. NW_003571057.1 Reference GRCh37.p5 PATCHES

      Range
      81433..90168, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 PATCHES

    Genomic

    1. NW_003571058.1 Reference GRCh37.p5 PATCHES

      Range
      81433..90168, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 PATCHES

    Genomic

    1. NW_003571059.1 Reference GRCh37.p5 PATCHES

      Range
      81433..90168, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 PATCHES

    Genomic

    1. NW_003571060.1 Reference GRCh37.p5 PATCHES

      Range
      81433..90168, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 PATCHES

    Genomic

    1. NW_003571061.1 Reference GRCh37.p5 PATCHES

      Range
      81433..90168, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      50926190..50935264, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC012314.8 (83827..92533) None
    genomic CH471135.1 EAW72185.1
      EAW72186.1
      EAW72187.1
      EAW72188.1
      EAW72189.1
    mRNA AF052052.1 AAD45182.1
    mRNA AK310627.1 None
    mRNA AK310647.1 None
    mRNA BC001728.1 None
    mRNA BC004281.1 AAH04281.1
    mRNA BC007776.2 AAH07776.1
    mRNA BI820344.1 None
    mRNA BQ027375.1 None
    other-genetic HQ447224.1 ADQ31711.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C1Z6.1 GenPept UniProtKB/Swiss-Prot:P0C1Z6
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...