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VPREB3 pre-B lymphocyte 3 [ Homo sapiens (human) ]

Gene ID: 29802, updated on 7-May-2016
Official Symbol
VPREB3provided by HGNC
Official Full Name
pre-B lymphocyte 3provided by HGNC
Primary source
HGNC:HGNC:12710
See related
Ensembl:ENSG00000128218 HPRD:05426; IMGT/GENE-DB:VPREB3; MIM:605017; Vega:OTTHUMG00000150738
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
8HS20; N27C7-2
Summary
The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015]
Orthologs
Location:
22q11.23; 22q11
Exon count:
2
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 22 NC_000022.11 (23752743..23754443, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24094930..24096630, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene glucuronidase, beta pseudogene 11 Neighboring gene ral guanine nucleotide dissociation stimulator like 4 Neighboring gene zinc finger protein 70 Neighboring gene chromosome 22 open reading frame 15 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10 Neighboring gene matrix metallopeptidase 11

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
immunoglobulin production IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
endoplasmic reticulum NAS
Non-traceable Author Statement
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
pre-B lymphocyte protein 3
Names
pre-B lymphocyte gene 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013378.2NP_037510.1  pre-B lymphocyte protein 3 precursor

    See identical proteins and their annotated locations for NP_037510.1

    Status: REVIEWED

    Source sequence(s)
    AF163825, AY359000, BQ899182
    Consensus CDS
    CCDS13813.1
    UniProtKB/Swiss-Prot
    Q9UKI3
    Related
    ENSP00000248948, OTTHUMP00000198415, ENST00000248948, OTTHUMT00000319879
    Conserved Domains (2) summary
    smart00410
    Location:28120
    IG_like; Immunoglobulin like
    cl11960
    Location:30122
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p2 Primary Assembly

    Range
    23752743..23754443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018933.2 Alternate CHM1_1.1

    Range
    24107172..24108872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)