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    OLA1 Obg-like ATPase 1 [ Homo sapiens ]

    Gene ID: 29789, updated on 11-May-2012

    Summary

    Official Symbol
    OLA1provided by HGNC
    Official Full Name
    Obg-like ATPase 1provided by HGNC
    Primary source
    HGNC:28833
    Locus tag
    PTD004
    See related
    Ensembl:ENSG00000138430; HPRD:15194; MIM:611175; Vega:OTTHUMG00000132335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DOC45; GBP45; GTBP9; GTPBP9; PTD004; DKFZp313H1942

    Genomic context

    Location :
    2q31.1
    Sequence :
    Chromosome: 2; NC_000002.11 (174937175..175113365, complement)
    See OLA1 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100128905 Neighboring gene ribosomal protein SA pseudogene 24 Neighboring gene leucine rich repeat containing 2 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9NTK5 Q9H1I8 ASCC2    HPRD  PubMed  
    Q9NTK5 O14744 PRMT5    HPRD  PubMed  
    BioGRID:118917 BioGRID:123921 ASCC2    BioGRID  PubMed Two-hybrid 
    BioGRID:118917 BioGRID:107076 BCL6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118917 BioGRID:115688 PRMT5    BioGRID  PubMed Two-hybrid 
    BioGRID:118917 BioGRID:116502 PUF60    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118917 BioGRID:111822 RAD21    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:118917 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    • Homologs of the OLA1 gene: The OLA1 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, rice, and P.falciparum.
    • Map Viewer (Mouse, Rat)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ATP catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    obg-like ATPase 1
    Names
    obg-like ATPase 1
    GTP-binding protein PTD004
    homologous yeast-44.2 protein
    GTP-binding protein 9 (putative)
    DNA damage-regulated overexpressed in cancer 45 protein
    NP_001011708.1
    NP_037473.3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011708.1NP_001011708.1  obg-like ATPase 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon in the 5' region, as compared to variant 1, resulting in a downstream AUG start codon and an N-terminal shorter isoform (2).
      Source sequence(s)
      AC016737, AK074710, BC012842
      Consensus CDS
      CCDS42779.1
      UniProtKB/Swiss-Prot
      Q9NTK5
      Related
      ENSP00000340167, OTTHUMP00000205066, ENST00000344357, OTTHUMT00000333876
      Conserved Domains (2) summary
      cd04867
      Location:147229
      Blast Score: 454
      TGS_YchF_C; TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the ...
      cl09099
      Location:1145
      Blast Score: 414
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_013341.3NP_037473.3  obg-like ATPase 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC016737, BC012842
      Consensus CDS
      CCDS2255.1
      UniProtKB/TrEMBL
      D7EHM2
      UniProtKB/Swiss-Prot
      Q9NTK5
      Related
      ENSP00000284719, OTTHUMP00000163173, ENST00000284719, OTTHUMT00000255454
      Conserved Domains (3) summary
      cd04867
      Location:305387
      Blast Score: 463
      TGS_YchF_C; TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the ...
      PTZ00258
      Location:18390
      Blast Score: 1573
      PTZ00258; GTP-binding protein; Provisional
      cd01900
      Location:25303
      Blast Score: 1138
      YchF; YchF GTPase

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      174937175..175113365, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      166816707..166992907, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

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