Sign in to NCBI

Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    NCAPH2 non-SMC condensin II complex, subunit H2 [ Homo sapiens (human) ]

    Gene ID: 29781, updated on 5-May-2013
    Official Symbol
    NCAPH2provided by HGNC
    Official Full Name
    non-SMC condensin II complex, subunit H2provided by HGNC
    Primary source
    HGNC:25071
    See related
    Ensembl:ENSG00000025770; MIM:611230; Vega:OTTHUMG00000150205
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAPH2
    Summary
    This gene encodes one of the non-SMC subunits of the condensin II complex. This complex plays an essential role in mitotic chromosome assembly. Alternate splicing of this gene results in multiple transcript variants.[provided by RefSeq, May 2010]
    Location :
    22q13.33
    Sequence :
    Chromosome: 22; NC_000022.10 (50946645..50963209)
    See NCAPH2 in Epigenomics, MapViewer

    Chromosome 22 - NC_000022.10Genomic Context describing neighboring genes Neighboring gene myo-inositol oxygenase Neighboring gene lipase maturation factor 2 Neighboring gene SCO2 cytochrome c oxidase assembly protein Neighboring gene thymidine phosphorylase Neighboring gene outer dense fiber of sperm tails 3B

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, et al. Mol Cell Proteomics, 2012 May. PMID 22505724.
    2. Toward an understanding of the protein interaction network of the human liver. Wang J, et al. Mol Syst Biol, 2011 Oct 11. PMID 21988832.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086.
    5. Condensin and cohesin complexity: the expanding repertoire of functions. Wood AJ, et al. Nat Rev Genet, 2010 Jun. PMID 20442714.

    See all (13) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    3. The CAP-H2 subunit of the condensin II complex implicated in chromosome assembly and segregation
      Title: Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:118913 BioGRID:108631 FOLR1    BioGRID  PubMed Two-hybrid 
    BioGRID:118913 BioGRID:110191 LMO2    BioGRID  PubMed Two-hybrid 
    BioGRID:118913 BioGRID:116902 NCAPD3    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:118913 BioGRID:120239 NCAPG2    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:118913 BioGRID:115841 SMC2    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:118913 BioGRID:115362 SMC4    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:118913 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Genotypes

    Homology

    Clone Names

    • MGC2455, MGC4133, MGC5305, MGC8640, MGC15858, MGC18000

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    condensin-2 complex subunit H2
    Names
    condensin-2 complex subunit H2
    kleisin beta
    chromosome-associated protein H2
    CAP-H2 subunit of the condensin II complex

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021419.1 RefSeqGene

      Range
      5001..21565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001185011.1 → NP_001171940.1  condensin-2 complex subunit H2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding region, compared to variant 1. The resulting protein (isoform 3) has a distinct C-terminus and is longer than isoform 1.
      Source sequence(s)
      BC009441, DB498781, U62317
      Consensus CDS
      CCDS54546.1
      UniProtKB/Swiss-Prot
      Q6IBW4
      Conserved Domains (1) summary
      pfam06278
      Location:51 – 606
      Blast Score: 1985
      DUF1032; Protein of unknown function (DUF1032)

    2. NM_014551.4 → NP_055366.3  condensin-2 complex subunit H2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      BC001833, BU632273, DB498781
      Consensus CDS
      CCDS43038.1
      UniProtKB/Swiss-Prot
      Q6IBW4
      Related
      ENSP00000379050, OTTHUMP00000196603, ENST00000395698, OTTHUMT00000316829
      Conserved Domains (1) summary
      pfam06278
      Location:51 – 287
      Blast Score: 743
      DUF1032; Protein of unknown function (DUF1032)

    3. NM_152299.3 → NP_689512.2  condensin-2 complex subunit H2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding region, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is longer than isoform 1.
      Source sequence(s)
      BC001937, BC009441, DB498781, U62317
      Consensus CDS
      CCDS14094.2
      UniProtKB/Swiss-Prot
      Q6IBW4
      Conserved Domains (1) summary
      pfam06278
      Location:51 – 605
      Blast Score: 1992
      DUF1032; Protein of unknown function (DUF1032)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000022.10 Reference GRCh37.p10 Primary Assembly

      Range
      50946645..50963209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000154.1 Alternate HuRef

      Range
      33837777..33854227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018933.1 Alternate CHM1_1.0

      Range
      34889643..34906206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01042625.1 (37444..46450) None
    genomic ABBA01042626.1 None
    genomic ABBA01042627.1 None
    genomic AMYH01012916.1 (170..16733) None
    genomic CH471138.1 EAW73552.1
      EAW73553.1
      EAW73554.1
      EAW73555.1
      EAW73556.1
      EAW73557.1
      EAW73558.1
      EAW73559.1
    genomic U62317.2 AAB03345.1
    mRNA AL021682.1 CAA16670.1
    mRNA BC000473.2 AAH00473.1
    mRNA BC001298.1 None
    mRNA BC001509.2 AAH01509.1
    mRNA BC001833.2 AAH01833.1
    mRNA BC001937.1 AAH01937.1
    mRNA BC009441.1 AAH09441.1
    mRNA BC014939.1 AAH14939.2
    mRNA BM802841.1 None
    mRNA BU632273.1 None
    mRNA CR456604.1 CAG30490.1
    mRNA DB498781.1 None
    mRNA DQ579583.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IBW4.1 GenPept UniProtKB/Swiss-Prot:Q6IBW4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • SNP: VarView
        Related Clinical SNP
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...