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    GUCY1A2 guanylate cyclase 1, soluble, alpha 2 [ Homo sapiens ]

    Gene ID: 2977, updated on 19-May-2012
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    Summary

    Official Symbol
    GUCY1A2provided by HGNC
    Official Full Name
    guanylate cyclase 1, soluble, alpha 2provided by HGNC
    Primary source
    HGNC:4684
    See related
    Ensembl:ENSG00000152402; HPRD:03146; MIM:601244; Vega:OTTHUMG00000166296
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GC-SA2; GUC1A2
    Summary
    Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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    Genomic context

    Location :
    11q21-q22
    Sequence :
    Chromosome: 11; NC_000011.9 (106557910..106889171, complement)
    See GUCY1A2 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Neighboring gene kelch repeat and BTB (POZ) domain containing 3 Neighboring gene G1 to S phase transition pseudogene Neighboring gene TSPY-like 1 pseudogene Neighboring gene RecQ protein-like (DNA helicase Q1-like) pseudogene Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 pseudogene Neighboring gene argininosuccinate synthetase 1 pseudogene 13 Neighboring gene CWF19-like 2, cell cycle control (S. pombe) Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 pseudogene 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Gene-environment interaction in the etiology of mathematical ability using SNP sets. Docherty SJ, et al. Behav Genet, 2011 Jan. PMID 20978832.
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    3. Role of soluble guanylyl cyclase-cyclic GMP signaling in tumor cell proliferation. Mujoo K, et al. Nitric Oxide, 2010 Jan 1. PMID 19948239.
    4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Trynka G, et al. Gut, 2009 Aug. PMID 19240061.
    5. Chaperone-dependent E3 ligase CHIP ubiquitinates and mediates proteasomal degradation of soluble guanylyl cyclase. Xia T, et al. Am J Physiol Heart Circ Physiol, 2007 Nov. PMID 17873020.

    See all (14) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
      Title: Gene-environment interaction in the etiology of mathematical ability using SNP sets.
    2. The sGC alpha 1observed in OVCAR-3 and MDA-MB-468 cancer cells which correlated well with the sGC activity and a marked increase in cGMP levels upon exposure to the combination of a NO donor and a sGC activator.
      Title: Role of soluble guanylyl cyclase-cyclic GMP signaling in tumor cell proliferation.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
    5. No significant changes were found in sGC subunit mRNAs in people with schizophrenia or in controls.
      Title: Expression of nNOS and soluble guanylate cyclase in schizophrenic brain.
    6. Soluble guanylyl cyclase (sGC) is the major cellular receptor for the intercellular messenger nitric oxide (NO) and mediates a wide range of physiological effects through elevation of intracellular cGMP levels
      Title: On the activation of soluble guanylyl cyclase by nitric oxide.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P33402 Q12959 DLG1    HPRD  PubMed  
    P33402 Q15700 DLG2    HPRD  PubMed  
    P33402 Q92796 DLG3    HPRD  PubMed  
    P33402 P78352 DLG4    HPRD  PubMed  
    P33402 Q02153 GUCY1B3    HPRD  PubMed  
    BioGRID:109232 BioGRID:108083 DLG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109232 BioGRID:108084 DLG2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109232 BioGRID:108085 DLG3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109232 BioGRID:108086 DLG4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109232 BioGRID:109238 GUCY1B3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109232 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109232 BioGRID:109540 HSPA4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109232 BioGRID:115563 STUB1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:109232 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Gap junction, organism-specific biosystem (from KEGG)
      Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Gap junction, conserved biosystem (from KEGG)
      Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Long-term depression, organism-specific biosystem (from KEGG)
      Long-term depression, organism-specific biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
    • Long-term depression, conserved biosystem (from KEGG)
      Long-term depression, conserved biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
    • Nitric oxide stimulates guanylate cyclase, organism-specific biosystem (from REACTOME)
      Nitric oxide stimulates guanylate cyclase, organism-specific biosystemNitric Oxide (NO) inhibits smooth muscle cell proliferation and migration, oxidation of low-density lipoproteins, and platelet aggregation and adhesion. It can stimulate vasodilatation of the endothe...
    • Platelet homeostasis, organism-specific biosystem (from REACTOME)
      Platelet homeostasis, organism-specific biosystemUnder normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in charact...
    • Purine metabolism, organism-specific biosystem (from KEGG)
      Purine metabolism, organism-specific biosystem
      Purine metabolism
    • Purine metabolism, conserved biosystem (from KEGG)
      Purine metabolism, conserved biosystem
      Purine metabolism
    • Salivary secretion, organism-specific biosystem (from KEGG)
      Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
    • Salivary secretion, conserved biosystem (from KEGG)
      Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
    • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
      Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
      Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    cGMP biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    guanylate cyclase soluble subunit alpha-2
    Names
    guanylate cyclase soluble subunit alpha-2
    GCS-alpha-2
    NP_000846.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000855.2 → NP_000846.1  guanylate cyclase soluble subunit alpha-2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AP005014, CA774108, X63282
      Consensus CDS
      CCDS8335.1
      UniProtKB/Swiss-Prot
      P33402
      Related
      ENSP00000431245, OTTHUMP00000232532, ENST00000526355, OTTHUMT00000389003
      Conserved Domains (4) summary
      cd07302
      Location:519 – 697
      Blast Score: 464
      CHD; cyclase homology domain
      smart00044
      Location:485 – 674
      Blast Score: 605
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam07701
      Location:311 – 503
      Blast Score: 724
      HNOBA; Heme NO binding associated
      cl15268
      Location:138 – 271
      Blast Score: 195
      HNOB; Heme NO binding

    2. NM_001256424.1 → NP_001243353.1  guanylate cyclase soluble subunit alpha-2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AP005014, CA774108, Z50053
      UniProtKB/Swiss-Prot
      P33402
      Conserved Domains (4) summary
      cd07302
      Location:519 – 728
      Blast Score: 425
      CHD; cyclase homology domain
      smart00044
      Location:485 – 705
      Blast Score: 566
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam07701
      Location:311 – 503
      Blast Score: 722
      HNOBA; Heme NO binding associated
      cl15268
      Location:138 – 271
      Blast Score: 195
      HNOB; Heme NO binding

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      106557910..106889171, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      102490806..102824743, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AP001282.4 None
    genomic AP001881.4 None
    genomic AP003078.2 (17284..39795) None
    genomic AP005014.3 (90881..144458) None
    genomic CH471065.1 EAW67081.1
    mRNA BC130484.1 AAI30485.1
    mRNA BC130488.1 AAI30489.1
    mRNA BC144033.1 AAI44034.1
    mRNA CA774108.1 None
    mRNA X63282.1 CAA44921.1
    mRNA Z50053.1 CAA90393.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33402.1 GenPept UniProtKB/Swiss-Prot:P33402
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

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