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    USP25 ubiquitin specific peptidase 25 [ Homo sapiens ]

    Gene ID: 29761, updated on 11-May-2012
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    Summary

    Official Symbol
    USP25provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 25provided by HGNC
    Primary source
    HGNC:12624
    See related
    Ensembl:ENSG00000155313; HPRD:05296; MIM:604736; Vega:OTTHUMG00000074343
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    USP21
    Summary
    Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]
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    Genomic context

    Location :
    21q11.2
    Sequence :
    Chromosome: 21; NC_000021.8 (17102496..17252377)
    See USP25 in Epigenomics, MapViewer

    Chromosome 21 - NC_000021.8Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100652984 Neighboring gene cytochrome c, somatic pseudogene 42 Neighboring gene RNA binding protein with multiple splicing-like pseudogene Neighboring gene long intergenic non-protein coding RNA 478 Neighboring gene voltage-dependent anion channel 2 pseudogene 1 Neighboring gene ribosomal protein S26 pseudogene 5

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Altun M, et al. Chem Biol, 2011 Nov 23. PMID 22118674.
    2. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. Do CB, et al. PLoS Genet, 2011 Jun. PMID 21738487.

    See all (25) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Studies indicate that DUBs recycle ubiquitin by processing polyubiquitin chains to generate free ubiquitin, and can be regulated by ubiquitination or phosphorylation.
      Title: PTMs in conversation: activity and function of deubiquitinating enzymes regulated via post-translational modifications.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    4. the second SH2 domain of SYK physically interacts with a tyrosine-rich, C-terminal region of USP25 independently of tyrosine phosphorylation
      Title: Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase.
    5. Data show that USP25m is regulated through alternative conjugation of ubiquitin (activating) or SUMO (inhibiting) to the same lysine residue (K99), which may promote the interaction with distinct intramolecular regulatory domains.
      Title: The UBA-UIM domains of the USP25 regulate the enzyme ubiquitination state and modulate substrate recognition.
    6. downregulation of USP25 gene in human lung cancer
      Title: Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer.
    7. Seven amino acids in the SIM of USP25 are sufficient for SUMO2/3-specific binding and conjugation
      Title: Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25.
    8. characterization of alternatively spliced products and tissue-specific isoforms
      Title: Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Genome-wide association study of panic disorder in the Japanese population.

    Web-based genome-wide association study identifies two novel Loci and a substantial genetic component for Parkinson's disease.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9UHP3 P12757 SKIL    HPRD  PubMed  
    BioGRID:118895 BioGRID:106573 ACTA1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:118895 BioGRID:106798 ANXA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118895 BioGRID:125343 BTBD9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118895 BioGRID:108607 FLNC    BioGRID  PubMed Two-hybrid 
    BioGRID:118895 BioGRID:108868 GAPDH    BioGRID  PubMed Two-hybrid 
    BioGRID:118895 BioGRID:123803 KCTD10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118895 BioGRID:129001 KCTD13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118895 BioGRID:124688 KLHL13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118895 BioGRID:121009 KLHL9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118895 BioGRID:110049 KRT4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118895 BioGRID:110247 LYZ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118895 BioGRID:110608 MT2A    BioGRID  PubMed Two-hybrid 
    BioGRID:118895 BioGRID:110689 MYBPC1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:118895 BioGRID:110730 MYO6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118895 BioGRID:110815 NEDD8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118895 BioGRID:111321 PIP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118895 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:118895 BioGRID:118895 USP25    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:118895 BioGRID:121683 USP28    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118895 BioGRID:121227 WRNIP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118895 BioGRID:125855 ZG16B    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SUMO binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ubiquitin thiolesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin-specific protease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    protein K48-linked deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein K63-linked deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein modification process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 25
    Names
    ubiquitin carboxyl-terminal hydrolase 25
    USP on chromosome 21
    ubiquitin thioesterase 25
    deubiquitinating enzyme 25
    ubiquitin thiolesterase 25
    ubiquitin specific protease 25
    ubiquitin-specific processing protease 25
    ubiquitin-specific-processing protease 25
    NP_037528.3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013396.3 → NP_037528.3  ubiquitin carboxyl-terminal hydrolase 25

      Status: VALIDATED

      Source sequence(s)
      AF134213, AF170562, BI256537, BQ215557
      Consensus CDS
      CCDS33515.1
      UniProtKB/Swiss-Prot
      Q9UHP3
      Related
      ENSP00000285679, OTTHUMP00000083056, ENST00000285679, OTTHUMT00000157964
      Conserved Domains (2) summary
      cd02665
      Location:258 – 404
      Blast Score: 575
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:168 – 297
      Blast Score: 148
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000021.8 Reference GRCh37.p5 Primary Assembly

      Range
      17102496..17252377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000153.1 Alternate HuRef

      Range
      2481855..2631589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AJ010597.1 (19419..105998) None
    genomic AJ010598.1 (12050..75351) None
    genomic CH471079.2 EAX10041.1
      EAX10042.1
      EAX10043.1
      EAX10044.1
      EAX10045.1
    mRNA AF134213.1 AAF24998.1
    mRNA AF170562.1 AAF32263.1
    mRNA AK022447.1 BAB14037.1
    mRNA AK022574.1 BAB14107.1
    mRNA AK094083.1 None
    mRNA BC015930.1 AAH15930.1
    mRNA BC018686.1 None
    mRNA BC075792.1 AAH75792.1
    mRNA BI256537.1 None
    mRNA BQ215557.1 None
    mRNA FJ763652.1 ACN76567.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96B65 GenPept UniProtKB/TrEMBL:Q96B65
    Q9HA22 GenPept UniProtKB/TrEMBL:Q9HA22
    Q9UHP3.4 GenPept UniProtKB/Swiss-Prot:Q9UHP3
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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