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    GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa [ Homo sapiens ]

    Gene ID: 2976, updated on 11-May-2012
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    Summary

    Official Symbol
    GTF3C2provided by HGNC
    Official Full Name
    general transcription factor IIIC, polypeptide 2, beta 110kDaprovided by HGNC
    Primary source
    HGNC:4665
    See related
    Ensembl:ENSG00000115207; HPRD:05347; MIM:604883; Vega:OTTHUMG00000097785
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TFIIIC110; TFIIIC-BETA; KIAA0011
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    Genomic context

    Location :
    2p23.3
    Sequence :
    Chromosome: 2; NC_000002.11 (27548721..27579868, complement)
    See GTF3C2 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 54 Neighboring gene MpV17 mitochondrial inner membrane protein Neighboring gene urocortin Neighboring gene uncharacterized LOC100505624 Neighboring gene uncharacterized LOC100505605 Neighboring gene eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa Neighboring gene sorting nexin 17

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Comparative proteomic analysis identifies a role for SUMO in protein quality control. Tatham MH, et al. Sci Signal, 2011 Jun 21. PMID 21693764.
    2. Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Rowbotham SP, et al. Mol Cell, 2011 May 6. PMID 21549307.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068.
    5. System-wide changes to SUMO modifications in response to heat shock. Golebiowski F, et al. Sci Signal, 2009 May 26. PMID 19471022.

    See all (25) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Evidence against the model that pol III transcription can be effectively modulated through the specific induction of TFIIIC110.
      Title: A test of the model that RNA polymerase III transcription is regulated by selective induction of the 110 kDa subunit of TFIIIC.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001512.1 NP_000312.1 RB1    BIND  PubMed Rb interacts with TFIIIC2 
    Q8WUA4 Q92664 GTF3A    HPRD  PubMed  
    Q8WUA4 Q9UKN8 GTF3C4    HPRD  PubMed  
    Q8WUA4 P06400 RB1    HPRD  PubMed  
    BioGRID:109231 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109231 BioGRID:114739 GTF3C3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109231 BioGRID:114738 GTF3C4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109231 BioGRID:114737 GTF3C5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109231 BioGRID:212141 Gtf3c6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109231 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109231 BioGRID:115868 POLR3C    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109231 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109231 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109231 BioGRID:112771 TBP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109231 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    5S class rRNA transcription from RNA polymerase III type 1 promoter IC
    Inferred by Curator
    more info
    		 PubMed 
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    tRNA transcription from RNA polymerase III promoter IC
    Inferred by Curator
    more info
    		 PubMed 
    transcription from RNA polymerase III promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription from RNA polymerase III promoter TAS
    Traceable Author Statement
    more info
    		  
    transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription factor TFIIIC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    general transcription factor 3C polypeptide 2
    Names
    general transcription factor 3C polypeptide 2
    TF3C-beta
    TFIIIC 110 kDa subunit
    transcription factor IIIC subunit beta
    transcription factor IIIC 110 kDa subunit
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035521.1 → NP_001030598.1  general transcription factor 3C polypeptide 2

      Status: VALIDATED

      Source sequence(s)
      AF054988, BP278201, D13636
      Consensus CDS
      CCDS1749.1
      UniProtKB/Swiss-Prot
      Q8WUA4
      Related
      ENSP00000264720, ENST00000264720
      Conserved Domains (1) summary
      cl02567
      Location:555 – 644
      Blast Score: 114
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001521.2 → NP_001512.1  general transcription factor 3C polypeptide 2

      Status: VALIDATED

      Source sequence(s)
      AF054988, BP249089, D13636
      Consensus CDS
      CCDS1749.1
      UniProtKB/Swiss-Prot
      Q8WUA4
      Conserved Domains (1) summary
      cl02567
      Location:555 – 644
      Blast Score: 114
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      27548721..27579868, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      27290904..27322036, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC013413.6 AAY24299.1
    genomic AC074117.7 (189315..195879) None
    genomic AC109828.4 AAY24049.1
    genomic CH471053.2 EAX00594.1
      EAX00595.1
      EAX00596.1
    mRNA AF054988.1 AAC09349.1
    mRNA AK307656.1 None
    mRNA BC000212.2 AAH00212.1
    mRNA BC020981.1 AAH20981.1
    mRNA BP249089.1 None
    mRNA BP278201.1 None
    mRNA BT009799.1 AAP88801.1
    mRNA BX647092.1 None
    mRNA D13636.1 BAA02800.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q53QN0 GenPept UniProtKB/TrEMBL:Q53QN0
    Q53SY8 GenPept UniProtKB/TrEMBL:Q53SY8
    Q8WUA4.2 GenPept UniProtKB/Swiss-Prot:Q8WUA4
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

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