U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Washc2c WASH complex subunit 2C [ Rattus norvegicus (Norway rat) ]

Gene ID: 297530, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Washc2cprovided by RGD
Official Full Name
WASH complex subunit 2Cprovided by RGD
Primary source
RGD:735230
See related
Ensembl:ENSRNOG00000011653 AllianceGenome:RGD:735230
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam21; Fam21c; Washc2; NP61201
Summary
Predicted to enable phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and retromer complex binding activity. Predicted to be involved in several processes, including endosomal transport; negative regulation of barbed-end actin filament capping; and regulation of substrate adhesion-dependent cell spreading. Predicted to be located in cytosol; endosome; and nucleolus. Predicted to be part of WASH complex. Predicted to be active in early endosome. Orthologous to human WASHC2A (WASH complex subunit 2A) and WASHC2C (WASH complex subunit 2C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 299.6), Brain (RPKM 274.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4q42
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (150912863..150998301)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (149267851..149325850)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (148139512..148197363)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene plexin D1 Neighboring gene transmembrane and coiled-coil domain family 1 Neighboring gene small RNA binding exonuclease protection factor La like 1 Neighboring gene ribosomal protein L9, pseudogene 19 Neighboring gene zinc finger AN1-type containing 4 Neighboring gene membrane associated ring-CH-type finger 8 Neighboring gene ribosomal protein L23A like 6

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer. Helfer E, et al. Biol Cell, 2013 May. PMID 23331060
  2. Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling. McGough IJ, et al. J Cell Sci, 2014 Nov 15. PMID 25278552, Free PMC Article
  3. Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35. Harbour ME, et al. Biochem J, 2012 Feb 15. PMID 22070227
  4. WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes. Jia D, et al. Proc Natl Acad Sci U S A, 2010 Jun 8. PMID 20498093, Free PMC Article
  5. A FAM21-containing WASH complex regulates retromer-dependent sorting. Gomez TS, et al. Dev Cell, 2009 Nov. PMID 19922874, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-5-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables retromer complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables retromer complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of barbed-end actin filament capping ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to endosome ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of WASH complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of WASH complex IEA
Inferred from Electronic Annotation
more info
  
part_of WASH complex ISO
Inferred from Sequence Orthology
more info
  
part_of WASH complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
WASH complex subunit 2
Names
WASH complex subunit FAM21
family with sequence similarity 21, member C

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199207.2 → NP_954677.2  WASH complex subunit 2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q80X08
    Related
    ENSRNOP00000015620.6, ENSRNOT00000015620.7
    Conserved Domains (1) summary
    pfam15255
    Location:946 → 1068
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    150912863..150998301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285891.1 → XP_063141961.1  WASH complex subunit 2 isoform X7

  2. XM_039107431.2 → XP_038963359.1  WASH complex subunit 2 isoform X8

    UniProtKB/Swiss-Prot
    Q80X08
    Conserved Domains (1) summary
    pfam15255
    Location:924 → 1046
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

  3. XM_039107428.2 → XP_038963356.1  WASH complex subunit 2 isoform X5

    UniProtKB/Swiss-Prot
    Q80X08
    Conserved Domains (1) summary
    pfam15255
    Location:946 → 1068
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

  4. XM_063285890.1 → XP_063141960.1  WASH complex subunit 2 isoform X6

  5. XM_006237147.5 → XP_006237209.1  WASH complex subunit 2 isoform X2

    UniProtKB/Swiss-Prot
    Q80X08
    UniProtKB/TrEMBL
    A0A8I6ADQ6
    Related
    ENSRNOP00000090531.1
    Conserved Domains (1) summary
    pfam15255
    Location:925 → 1043
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

  6. XM_039107425.2 → XP_038963353.1  WASH complex subunit 2 isoform X1

    UniProtKB/Swiss-Prot
    Q80X08
    Conserved Domains (1) summary
    pfam15255
    Location:945 → 1067
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

  7. XM_006237149.5 → XP_006237211.1  WASH complex subunit 2 isoform X4

    UniProtKB/Swiss-Prot
    Q80X08
    UniProtKB/TrEMBL
    A0A8I6AM40
    Related
    ENSRNOP00000096602.1
    Conserved Domains (1) summary
    pfam15255
    Location:903 → 1030
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

  8. XM_039107426.2 → XP_038963354.1  WASH complex subunit 2 isoform X3

    UniProtKB/Swiss-Prot
    Q80X08
    Conserved Domains (1) summary
    pfam15255
    Location:925 → 1047
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80X08.1 GenPept UniProtKB/Swiss-Prot:Q80X08

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous