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GTF3C1 general transcription factor IIIC subunit 1 [ Homo sapiens (human) ]

Gene ID: 2975, updated on 26-May-2016
Official Symbol
GTF3C1provided by HGNC
Official Full Name
general transcription factor IIIC subunit 1provided by HGNC
Primary source
HGNC:HGNC:4664
See related
Ensembl:ENSG00000077235 HPRD:07540; MIM:603246; Vega:OTTHUMG00000176805
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TFIIIC; TFIIIC220; TFIIICalpha
Orthologs
Location:
16p12
Exon count:
37
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (27460613..27549930, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (27471934..27561251, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene interleukin 4 receptor Neighboring gene interleukin 21 receptor Neighboring gene IL21R antisense RNA 1 Neighboring gene KIAA0556 Neighboring gene uncharacterized LOC100128079 Neighboring gene uncharacterized LOC105371157

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp686A111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to DNA binding IC
Inferred by Curator
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
intracellular ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
transcription factor TFIIIC complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
general transcription factor 3C polypeptide 1
Names
TF3C-alpha
TFIIIC 220 kDa subunit
TFIIIC box B-binding subunit
general transcription factor IIIC, polypeptide 1 (alpha subunit)
general transcription factor IIIC, polypeptide 1, alpha 220kDa
transcription factor IIIC 220 kDa subunit
transcription factor IIIC subunit alpha

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286242.1NP_001273171.1  general transcription factor 3C polypeptide 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC002303, AC025275, BC044857, BC137229
    Consensus CDS
    CCDS66988.1
    UniProtKB/Swiss-Prot
    Q12789
    Related
    ENSP00000455417, OTTHUMP00000255146, ENST00000561623, OTTHUMT00000433855
    Conserved Domains (2) summary
    pfam04182
    Location:174250
    B-block_TFIIIC; B-block binding subunit of TFIIIC
    pfam10667
    Location:18321950
    DUF2486; Protein of unknown function (DUF2486)
  2. NM_001520.3NP_001511.2  general transcription factor 3C polypeptide 1 isoform 1

    See identical proteins and their annotated locations for NP_001511.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC044857, BC137229, BP283960, CA414192, U02619
    Consensus CDS
    CCDS32414.1
    UniProtKB/Swiss-Prot
    Q12789
    Related
    ENSP00000348510, OTTHUMP00000255147, ENST00000356183, OTTHUMT00000433856
    Conserved Domains (1) summary
    pfam04182
    Location:174250
    B-block_TFIIIC; B-block binding subunit of TFIIIC

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    27460613..27549930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545815.1XP_011544117.1  

    Conserved Domains (1) summary
    pfam04182
    Location:174250
    B-block_TFIIIC; B-block binding subunit of TFIIIC
  2. XM_011545814.1XP_011544116.1  

    Conserved Domains (2) summary
    pfam04182
    Location:174250
    B-block_TFIIIC; B-block binding subunit of TFIIIC
    pfam10667
    Location:18381956
    DUF2486; Protein of unknown function (DUF2486)
  3. XM_011545813.1XP_011544115.1  

    Conserved Domains (1) summary
    pfam04182
    Location:174250
    B-block_TFIIIC; B-block binding subunit of TFIIIC

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    28483652..28572971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)