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GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa [ Homo sapiens (human) ]

Gene ID: 2975, updated on 6-Jul-2014
Official Symbol
GTF3C1provided by HGNC
Official Full Name
general transcription factor IIIC, polypeptide 1, alpha 220kDaprovided by HGNC
Primary source
HGNC:4664
See related
Ensembl:ENSG00000077235; HPRD:07540; MIM:603246; Vega:OTTHUMG00000176805
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TFIIIC; TFIIIC220; TFIIICalpha
See GTF3C1 in Epigenomics, MapViewer
Location:
16p12
Exon count :
37
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 16 NC_000016.10 (27460613..27549930, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (27471934..27561251, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene interleukin 4 receptor Neighboring gene interleukin 21 receptor Neighboring gene IL21R antisense RNA 1 Neighboring gene KIAA0556 Neighboring gene uncharacterized LOC100128079 Neighboring gene GSG1-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat, p14 tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to DNA binding IC
Inferred by Curator
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
transcription factor TFIIIC complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
general transcription factor 3C polypeptide 1
Names
general transcription factor 3C polypeptide 1
TF3C-alpha
TFIIIC 220 kDa subunit
TFIIIC box B-binding subunit
transcription factor IIIC subunit alpha
transcription factor IIIC 220 kDa subunit
general transcription factor IIIC, polypeptide 1 (alpha subunit)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286242.1NP_001273171.1  general transcription factor 3C polypeptide 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC002303, AC025275, BC044857, BC137229
    Consensus CDS
    CCDS66988.1
    UniProtKB/Swiss-Prot
    Q12789
    Conserved Domains (2) summary
    pfam04182
    Location:174250
    Blast Score: 229
    B-block_TFIIIC; B-block binding subunit of TFIIIC
    pfam10667
    Location:18321950
    Blast Score: 102
    DUF2486; Protein of unknown function (DUF2486)
  2. NM_001520.3NP_001511.2  general transcription factor 3C polypeptide 1 isoform 1

    See proteins identical to NP_001511.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC044857, BC137229, BP283960, CA414192, U02619
    Consensus CDS
    CCDS32414.1
    UniProtKB/Swiss-Prot
    Q12789
    Related
    ENSP00000348510, OTTHUMP00000255147, ENST00000356183, OTTHUMT00000433856
    Conserved Domains (1) summary
    pfam04182
    Location:174250
    Blast Score: 229
    B-block_TFIIIC; B-block binding subunit of TFIIIC

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000016.10 

    Range
    27460613..27549930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721042.1XP_006721105.1  

    Conserved Domains (1) summary
    pfam04182
    Location:174250
    Blast Score: 229
    B-block_TFIIIC; B-block binding subunit of TFIIIC

Alternate HuRef

Genomic

  1. AC_000148.1 

    Range
    25560380..25649634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 

    Range
    28483652..28572971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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