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Nfu1 NFU1 iron-sulfur cluster scaffold [ Rattus norvegicus (Norway rat) ]

Gene ID: 297416, updated on 11-Apr-2024

Summary

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Official Symbol
Nfu1provided by RGD
Official Full Name
NFU1 iron-sulfur cluster scaffoldprovided by RGD
Primary source
RGD:1307823
See related
Ensembl:ENSRNOG00000018410 AllianceGenome:RGD:1307823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hirip5
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity and iron ion binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 1. Orthologous to human NFU1 (NFU1 iron-sulfur cluster scaffold). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 150.5), Muscle (RPKM 128.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q34
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (121016316..121036925)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (119458981..119480162)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (118814284..118834955)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene AP2 associated kinase 1 Neighboring gene uncharacterized LOC134486608 Neighboring gene uncharacterized LOC120102328 Neighboring gene glutamine fructose-6-phosphate transaminase 1 Neighboring gene ANTXR cell adhesion molecule 1 Neighboring gene uncharacterized LOC120102329

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Single Mutation in the NFU1 Gene Metabolically Reprograms Pulmonary Artery Smooth Muscle Cells. James J, et al. Arterioscler Thromb Vasc Biol, 2021 Feb. PMID 33297749, Free PMC Article
  2. Understanding the molecular basis for multiple mitochondrial dysfunctions syndrome 1 (MMDS1): impact of a disease-causing Gly189Arg substitution on NFU1. Wesley NA, et al. FEBS J, 2017 Nov. PMID 28906594, Free PMC Article
  3. The Lafora disease gene product laforin interacts with HIRIP5, a phylogenetically conserved protein containing a NifU-like domain. Ganesh S, et al. Hum Mol Genet, 2003 Sep 15. PMID 12915448
  4. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N, et al. Biochim Biophys Acta, 2015 Jun. PMID 25245479, Free PMC Article
  5. Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster. Tong WH, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12886008, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Single Mutation in the NFU1 Gene Metabolically Reprograms Pulmonary Artery Smooth Muscle Cells.
    Title: Single Mutation in the NFU1 Gene Metabolically Reprograms Pulmonary Artery Smooth Muscle Cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
  
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in iron-sulfur cluster assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein maturation by [4Fe-4S] cluster transfer IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
Names
histone cell cycle regulation defective interacting protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106606.2 → NP_001100076.2  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001100076.2

    Status: VALIDATED

    Source sequence(s)
    FM058785, FM064033, FM092780
    UniProtKB/TrEMBL
    A6IAZ7, D3ZA85
    Related
    ENSRNOP00000024884.6, ENSRNOT00000024884.7
    Conserved Domains (2) summary
    smart00932
    Location:59 → 146
    Nfu_N; Scaffold protein Nfu/NifU N terminal
    pfam01106
    Location:171 → 237
    NifU; NifU-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    121016316..121036925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285813.1 → XP_063141883.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X1

  2. XM_063285814.1 → XP_063141884.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X2

  3. XM_039107363.2 → XP_038963291.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X4

    Conserved Domains (2) summary
    pfam01106
    Location:81 → 147
    NifU; NifU-like domain
    cl07364
    Location:33 → 56
    Nfu_N; Scaffold protein Nfu/NifU N terminal

  4. XM_063285815.1 → XP_063141885.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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