Apbb1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) [Rattus norvegicus] - Gene

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Summary

Official Symbol: Apbb1provided by RGD
Official Full Name: amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)provided by RGD
Primary source: RGD:2122
See related: Ensembl:ENSRNOG00000018020
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as: FE65
Summary: displays in vitro binding to the NPTY intracellular domain of the Alzheimers disease associated human beta amyloid precursor protein [RGD, Feb 2006]

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Genomic context

Location :: 1q33

Sequence :: Chromosome: 1; NC_005100.2 (163282918..163299333, complement)

See Apbb1 in MapViewer

Chromosome 1 - NC_005100.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A novel Fe65 isoform and the regulation of the splicing events leading to its production may contribute to clarification of neuronal-specific roles of Fe65 and its contribution to Alzheimer disease pathology.
Title: Identification and characterization of a neuronal enriched novel transcript encoding the previously described p60Fe65 isoform.
Data show that APP nuclear signaling is altered by Abeta, affecting not only AICD production but also its nuclear translocation and complex formation with Fe65.
Title: Alphabeta hinders nuclear targeting of AICD and Fe65 in primary neuronal cultures.
Dexras1 functions as a suppressor of FE65-APP-mediated transcription, and FE65 tyrosine 547 phosphorylation enhances FE65-APP-mediated transcription, at least in part, by modulating the interaction between FE65 and Dexras1
Title: Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription.
These data suggest that SGK1 phosphorylates the Ser(566) residue of Fe65 and that this phosphorylation promotes the migration of Fe65 to the nucleus of the cell.
Title: Regulation Fe65 localization to the nucleus by SGK1 phosphorylation of its Ser566 residue.
Secondary structure of the recombinant proteins showed a different degree of unordered structures, the PTB2 domain being the higher organised region
Title: Probing the secondary structure of a recombinant neuronal adaptor protein and its phosphotyrosine binding domains.

Submit: New GeneRIF Correction

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_536726.1		Aplp1	BIND	PubMed	Fe65 interacts with APLP1.
NP_536726.1	CAA54906.1	Aplp2	BIND	PubMed	Fe65 interacts with APLP2.
NP_536726.1	NP_062161.1	App	BIND	PubMed	Beta-APP interacts with FE65.
NP_536726.1	NP_062161.1	App	BIND	PubMed	Fe65 interacts with APP.
NP_536726.1	NP_062161.1	App	BIND	PubMed	Fe65 interacts with APP. This interaction was modeled on a demonstrated interaction between rat Fe65 and human APP.
NP_536726.1	XP_235662.2	Tcfcp2	BIND	PubMed	Fe65 interacts with LSF (CP2/LSF/LBP1).
BioGRID:248339	BioGRID:106848	APP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:248339	BioGRID:116915	NEDD4L	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Co-localization
BioGRID:248339	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
beta-amyloid binding	IEA Inferred from Electronic Annotation more info
beta-amyloid binding	IPI Inferred from Physical Interaction more info	PubMed
beta-amyloid binding	ISO Inferred from Sequence Orthology more info
beta-amyloid binding	ISS Inferred from Sequence or Structural Similarity more info
chromatin binding	ISO Inferred from Sequence Orthology more info
histone binding	ISO Inferred from Sequence Orthology more info
proline-rich region binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein complex binding	IPI Inferred from Physical Interaction more info	PubMed
transcription factor binding	IEA Inferred from Electronic Annotation more info
transcription factor binding	ISO Inferred from Sequence Orthology more info
transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
axon guidance	IEA Inferred from Electronic Annotation more info
axon guidance	ISO Inferred from Sequence Orthology more info
cell cycle arrest	IEA Inferred from Electronic Annotation more info
cell cycle arrest	ISO Inferred from Sequence Orthology more info
cell cycle arrest	ISS Inferred from Sequence or Structural Similarity more info
chromatin modification	IEA Inferred from Electronic Annotation more info
double-strand break repair	IEA Inferred from Electronic Annotation more info
double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
double-strand break repair	ISO Inferred from Sequence Orthology more info
extracellular matrix organization	IEA Inferred from Electronic Annotation more info
extracellular matrix organization	ISO Inferred from Sequence Orthology more info
histone H4 acetylation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of S phase of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
negative regulation of S phase of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
negative regulation of S phase of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
negative regulation of thymidylate synthase biosynthetic process	IEA Inferred from Electronic Annotation more info
negative regulation of thymidylate synthase biosynthetic process	ISO Inferred from Sequence Orthology more info
negative regulation of thymidylate synthase biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
neuron migration	IEA Inferred from Electronic Annotation more info
neuron migration	ISO Inferred from Sequence Orthology more info
positive regulation of DNA repair	IEA Inferred from Electronic Annotation more info
positive regulation of DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of DNA repair	ISO Inferred from Sequence Orthology more info
positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
regulation of transcription, DNA-dependent	ISS Inferred from Sequence or Structural Similarity more info
response to DNA damage stimulus	IEA Inferred from Electronic Annotation more info
response to DNA damage stimulus	ISO Inferred from Sequence Orthology more info
response to iron ion	IEP Inferred from Expression Pattern more info	PubMed
visual learning	IEA Inferred from Electronic Annotation more info
visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoplasm	ISO Inferred from Sequence Orthology more info
dendritic spine	IDA Inferred from Direct Assay more info	PubMed
growth cone	IDA Inferred from Direct Assay more info	PubMed
growth cone	ISO Inferred from Sequence Orthology more info
growth cone	ISS Inferred from Sequence or Structural Similarity more info
lamellipodium	ISO Inferred from Sequence Orthology more info
lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
nuclear speck	IEA Inferred from Electronic Annotation more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info
nucleus	ISO Inferred from Sequence Orthology more info
nucleus	ISS Inferred from Sequence or Structural Similarity more info
perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	ISO Inferred from Sequence Orthology more info
postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
protein complex	IDA Inferred from Direct Assay more info	PubMed
synapse	ISO Inferred from Sequence Orthology more info
synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Preferred Names: amyloid beta A4 precursor protein-binding family B member 1

Names: amyloid beta A4 precursor protein-binding family B member 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080478.1 → NP_536726.1 amyloid beta A4 precursor protein-binding family B member 1

Status: PROVISIONAL

Source sequence(s)

AF333983

UniProtKB/Swiss-Prot

P46933

Related

ENSRNOP00000024402, ENSRNOT00000024402

Conserved Domains (2) summary

cl00157
Location:256 – 284
Blast Score: 112

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cl00273
Location:369 – 508
Blast Score: 497

PH-like; Pleckstrin homology-like domain