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Gabra1 gamma-aminobutyric acid type A receptor alpha1 subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 29705, updated on 26-May-2016
Official Symbol
Gabra1provided by RGD
Official Full Name
gamma-aminobutyric acid type A receptor alpha1 subunitprovided by RGD
Primary source
RGD:61855
See related
Ensembl:ENSRNOG00000003512
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
subunit of GABAA receptors, which bind benzodiazepines and act as inhibitory ion channels in the brain [RGD, Feb 2006]
Orthologs
Location:
10q21
Exon count:
12
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (27310718..27366241, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (27154354..27209873, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103690411 Neighboring gene uncharacterized LOC102548672 Neighboring gene gamma-aminobutyric acid type A receptor gamma 2 subunit Neighboring gene uncharacterized LOC102547488 Neighboring gene gamma-aminobutyric acid type A receptor alpha 6 subunit

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to GABA receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
GABA-A receptor activity TAS
Traceable Author Statement
more info
PubMed 
benzodiazepine receptor activity TAS
Traceable Author Statement
more info
PubMed 
chloride channel activity IEA
Inferred from Electronic Annotation
more info
 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
inhibitory extracellular ligand-gated ion channel activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to histamine IDA
Inferred from Direct Assay
more info
PubMed 
chemical synaptic transmission, postsynaptic IEA
Inferred from Electronic Annotation
more info
 
chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
chloride transport TAS
Traceable Author Statement
more info
PubMed 
gamma-aminobutyric acid signaling pathway TAS
Traceable Author Statement
more info
PubMed 
synaptic transmission TAS
Traceable Author Statement
more info
 
synaptic transmission, GABAergic IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
GABA receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
GABA-A receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
gamma-aminobutyric acid receptor subunit alpha-1
Names
GABA(A) receptor subunit alpha-1
gamma-aminobutyric acid A receptor, alpha 1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1
gamma-aminobutyric acid A receptor, alpha 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183326.2NP_899155.1  gamma-aminobutyric acid receptor subunit alpha-1 precursor

    See identical proteins and their annotated locations for NP_899155.1

    Status: PROVISIONAL

    Source sequence(s)
    BC100061
    UniProtKB/Swiss-Prot
    P62813
    Related
    ENSRNOP00000004725, ENSRNOT00000004725
    Conserved Domains (3) summary
    pfam02931
    Location:42249
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:256438
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    TIGR00860
    Location:7441
    LIC; Cation transporter family protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    27310718..27366241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246124.2XP_006246186.1  

    See identical proteins and their annotated locations for XP_006246186.1

    UniProtKB/Swiss-Prot
    P62813
    Conserved Domains (3) summary
    pfam02931
    Location:42249
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:256438
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    TIGR00860
    Location:7441
    LIC; Cation transporter family protein
  2. XM_006246123.2XP_006246185.1  

    See identical proteins and their annotated locations for XP_006246185.1

    UniProtKB/Swiss-Prot
    P62813
    Conserved Domains (3) summary
    pfam02931
    Location:42249
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:256438
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    TIGR00860
    Location:7441
    LIC; Cation transporter family protein

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    26109305..26164180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)