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GTF2E1 general transcription factor IIE subunit 1 [ Homo sapiens (human) ]

Gene ID: 2960, updated on 8-May-2016
Official Symbol
GTF2E1provided by HGNC
Official Full Name
general transcription factor IIE subunit 1provided by HGNC
Primary source
HGNC:HGNC:4650
See related
Ensembl:ENSG00000153767 HPRD:01799; MIM:189962; Vega:OTTHUMG00000159667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FE; TF2E1; TFIIE-A
Orthologs
Location:
3q21-q24
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (120742711..120783070)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (120461558..120502216)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene homogentisate 1,2-dioxygenase Neighboring gene RAB, member of RAS oncogene family like 3 Neighboring gene uncharacterized LOC101926983 Neighboring gene nucleosome assembly protein 1 like 1 pseudogene 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of general transcription factor IIE, polypeptide 1, alpha 56kDa (GTF2E1; TFIIE1) by siRNA inhibits HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme and transcription preinitiation complexes, which include TFIIE, during Tat-mediated transactivation of the HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
snRNA transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription elongation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
general transcription factor IIE subunit 1
Names
TFIIE alpha subunit
TFIIE-alpha
general transcription factor IIE 56 kDa subunit
general transcription factor IIE, polypeptide 1, alpha 56kDa
transcription initiation factor IIE subunit alpha

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005513.2NP_005504.2  general transcription factor IIE subunit 1

    See identical proteins and their annotated locations for NP_005504.2

    Status: VALIDATED

    Source sequence(s)
    AC117472, DA498425, S67859
    Consensus CDS
    CCDS3002.1
    UniProtKB/Swiss-Prot
    P29083
    Related
    ENSP00000283875, OTTHUMP00000216144, ENST00000283875, OTTHUMT00000356770
    Conserved Domains (4) summary
    smart00531
    Location:28175
    TFIIE; Transcription initiation factor IIE
    pfam02002
    Location:16123
    TFIIE_alpha; TFIIE alpha subunit
    pfam08271
    Location:127174
    TF_Zn_Ribbon; TFIIB zinc-binding
    pfam11521
    Location:367439
    TFIIE-A_C-term; C-terminal general transcription factor TFIIE alpha

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    120742711..120783070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512745.1XP_011511047.1  

    See identical proteins and their annotated locations for XP_011511047.1

    UniProtKB/Swiss-Prot
    P29083
    Conserved Domains (4) summary
    smart00531
    Location:28175
    TFIIE; Transcription initiation factor IIE
    pfam02002
    Location:16123
    TFIIE_alpha; TFIIE alpha subunit
    pfam08271
    Location:127174
    TF_Zn_Ribbon; TFIIB zinc-binding
    pfam11521
    Location:367439
    TFIIE-A_C-term; C-terminal general transcription factor TFIIE alpha
  2. XM_011512744.1XP_011511046.1  

    See identical proteins and their annotated locations for XP_011511046.1

    UniProtKB/Swiss-Prot
    P29083
    Conserved Domains (4) summary
    smart00531
    Location:28175
    TFIIE; Transcription initiation factor IIE
    pfam02002
    Location:16123
    TFIIE_alpha; TFIIE alpha subunit
    pfam08271
    Location:127174
    TF_Zn_Ribbon; TFIIB zinc-binding
    pfam11521
    Location:367439
    TFIIE-A_C-term; C-terminal general transcription factor TFIIE alpha

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    120425208..120465562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)