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Hes1 hes family bHLH transcription factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29577, updated on 8-May-2016
Official Symbol
Hes1provided by RGD
Official Full Name
hes family bHLH transcription factor 1provided by RGD
Primary source
RGD:62081
See related
Ensembl:ENSRNOG00000001720
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
may act as a transcriptional repressor; may inhibit cell adhesion molecule NCAM-dependent neurite outgrowth [RGD, Feb 2006]
Orthologs
Location:
11q22
Exon count:
4
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (74312837..74315249, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (77360109..77362521, complement)

Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554403 Neighboring gene uncharacterized LOC102547306 Neighboring gene uncharacterized LOC102547428 Neighboring gene uncharacterized LOC102547530

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
  • Fanconi anemia pathway, organism-specific biosystem (from KEGG)
    Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
  • Fanconi anemia pathway, conserved biosystem (from KEGG)
    Fanconi anemia pathway, conserved biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
  • Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
  • Maturity onset diabetes of the young, organism-specific biosystem (from KEGG)
    Maturity onset diabetes of the young, organism-specific biosystemAbout 2-5% of type II diabetic patients suffer from a monogenic disease with autosomal dominant inheritance. This monogenic form of type II diabetes is called maturity onset diabetes of the young (MO...
  • Maturity onset diabetes of the young, conserved biosystem (from KEGG)
    Maturity onset diabetes of the young, conserved biosystemAbout 2-5% of type II diabetic patients suffer from a monogenic disease with autosomal dominant inheritance. This monogenic form of type II diabetes is called maturity onset diabetes of the young (MO...
  • Notch signaling pathway, organism-specific biosystem (from KEGG)
    Notch signaling pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
  • Notch signaling pathway, conserved biosystem (from KEGG)
    Notch signaling pathway, conserved biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
JUN kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
N-box binding IDA
Inferred from Direct Assay
more info
PubMed 
N-box binding IEA
Inferred from Electronic Annotation
more info
 
N-box binding ISO
Inferred from Sequence Orthology
more info
 
N-box binding ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase II transcription factor activity, sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
chaperone binding IEA
Inferred from Electronic Annotation
more info
 
chaperone binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor activity, sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA
Inferred from Electronic Annotation
more info
 
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
Inferred from Sequence Orthology
more info
 
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
S-shaped body morphogenesis IEA
Inferred from Electronic Annotation
more info
 
STAT protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
STAT protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
STAT protein import into nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
adenohypophysis development IEA
Inferred from Electronic Annotation
more info
 
adenohypophysis development ISO
Inferred from Sequence Orthology
more info
 
aorta morphogenesis ISO
Inferred from Sequence Orthology
more info
 
artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
ascending aorta morphogenesis IEA
Inferred from Electronic Annotation
more info
 
ascending aorta morphogenesis ISO
Inferred from Sequence Orthology
more info
 
auditory receptor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
auditory receptor cell fate determination IEA
Inferred from Electronic Annotation
more info
 
auditory receptor cell fate determination ISO
Inferred from Sequence Orthology
more info
 
cardiac neural crest cell development involved in outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cardiac neural crest cell development involved in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell adhesion ISO
Inferred from Sequence Orthology
more info
 
cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
cell maturation IEA
Inferred from Electronic Annotation
more info
 
cell maturation ISO
Inferred from Sequence Orthology
more info
 
cell migration IEA
Inferred from Electronic Annotation
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cell morphogenesis involved in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis involved in neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
cellular response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to nerve growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
cochlea development IEA
Inferred from Electronic Annotation
more info
 
cochlea development ISO
Inferred from Sequence Orthology
more info
 
comma-shaped body morphogenesis IEA
Inferred from Electronic Annotation
more info
 
common bile duct development IEA
Inferred from Electronic Annotation
more info
 
common bile duct development ISO
Inferred from Sequence Orthology
more info
 
embryonic heart tube morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic heart tube morphogenesis ISO
Inferred from Sequence Orthology
more info
 
establishment of epithelial cell polarity IEA
Inferred from Electronic Annotation
more info
 
establishment of epithelial cell polarity ISO
Inferred from Sequence Orthology
more info
 
forebrain radial glial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
glomerulus vasculature development IEA
Inferred from Electronic Annotation
more info
 
hair cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hindbrain morphogenesis IEA
Inferred from Electronic Annotation
more info
 
hindbrain morphogenesis ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
inner ear receptor stereocilium organization IEA
Inferred from Electronic Annotation
more info
 
inner ear receptor stereocilium organization ISO
Inferred from Sequence Orthology
more info
 
labyrinthine layer blood vessel development IEA
Inferred from Electronic Annotation
more info
 
labyrinthine layer blood vessel development ISO
Inferred from Sequence Orthology
more info
 
lateral inhibition IEA
Inferred from Electronic Annotation
more info
 
lateral inhibition ISO
Inferred from Sequence Orthology
more info
 
liver development IEA
Inferred from Electronic Annotation
more info
 
liver development ISO
Inferred from Sequence Orthology
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
lung development ISO
Inferred from Sequence Orthology
more info
 
metanephric nephron tubule morphogenesis IEA
Inferred from Electronic Annotation
more info
 
midbrain development IEA
Inferred from Electronic Annotation
more info
 
midbrain development ISO
Inferred from Sequence Orthology
more info
 
midbrain-hindbrain boundary morphogenesis IEA
Inferred from Electronic Annotation
more info
 
midbrain-hindbrain boundary morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of auditory receptor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of auditory receptor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of calcium ion import IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of forebrain neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of glial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of inner ear receptor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of pancreatic A cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of pancreatic A cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of pro-B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of pro-B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of pro-B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of stomach neuroendocrine cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of stomach neuroendocrine cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
neural tube development ISO
Inferred from Sequence Orthology
more info
 
neuron differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
neuronal stem cell population maintenance IDA
Inferred from Direct Assay
more info
PubMed 
neuronal stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
neuronal stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
oculomotor nerve development IEA
Inferred from Electronic Annotation
more info
 
oculomotor nerve development ISO
Inferred from Sequence Orthology
more info
 
outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
pancreas development IEA
Inferred from Electronic Annotation
more info
 
pancreas development ISO
Inferred from Sequence Orthology
more info
 
pattern specification process ISO
Inferred from Sequence Orthology
more info
 
pharyngeal arch artery morphogenesis IEA
Inferred from Electronic Annotation
more info
 
pharyngeal arch artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
pituitary gland development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JAK-STAT cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of astrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of astrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitotic cell cycle, embryonic IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic cell cycle, embryonic ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein targeting to mitochondrion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of Stat3 protein IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of Stat3 protein ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of Stat3 protein ISS
Inferred from Sequence or Structural Similarity
more info
 
protein complex assembly IEA
Inferred from Electronic Annotation
more info
 
protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
protein complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of auditory receptor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of secondary heart field cardioblast proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of secondary heart field cardioblast proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of timing of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of timing of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of timing of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
renal interstitial fibroblast development IEA
Inferred from Electronic Annotation
more info
 
response to alkaloid IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to thyroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
somatic stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
telencephalon development IEA
Inferred from Electronic Annotation
more info
 
telencephalon development ISO
Inferred from Sequence Orthology
more info
 
thymus development IEA
Inferred from Electronic Annotation
more info
 
thymus development ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
trochlear nerve development IEA
Inferred from Electronic Annotation
more info
 
trochlear nerve development ISO
Inferred from Sequence Orthology
more info
 
ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
vascular smooth muscle cell development IEA
Inferred from Electronic Annotation
more info
 
vascular smooth muscle cell development ISO
Inferred from Sequence Orthology
more info
 
ventricular septum development ISO
Inferred from Sequence Orthology
more info
 
ventricular septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
transcription factor HES-1
Names
RHL
hairy and enhancer of split 1
hairy-like protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024360.3NP_077336.3  transcription factor HES-1

    See identical proteins and their annotated locations for NP_077336.3

    Status: PROVISIONAL

    Source sequence(s)
    BC061730
    UniProtKB/Swiss-Prot
    Q04666
    Related
    ENSRNOP00000002346, ENSRNOT00000002346
    Conserved Domains (2) summary
    cd00083
    Location:3295
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam07527
    Location:109150
    Hairy_orange; Hairy Orange

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

    Range
    74312837..74315249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000079.1 Alternate Rn_Celera

    Range
    69677011..69679422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)