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Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29540, updated on 26-May-2016
Official Symbol
Hsd17b7provided by RGD
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 7provided by RGD
Primary source
RGD:2837
See related
Ensembl:ENSRNOG00000002826
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
a phosphoprotein that associates with the short form of the prolactin receptor [RGD, Feb 2006]
Orthologs
Location:
13q24
Exon count:
10
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (88288116..88308011, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (92914581..92934289, complement)

Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signaling 4 Neighboring gene Da1-10-like Neighboring gene coiled-coil domain containing 190 Neighboring gene discoidin domain receptor tyrosine kinase 2 Neighboring gene betaine aldehyde dehydrogenase-like

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
3-keto sterol reductase activity IEA
Inferred from Electronic Annotation
more info
 
3-keto sterol reductase activity ISO
Inferred from Sequence Orthology
more info
 
estradiol 17-beta-dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
prolactin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
estrogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
hippocampus development IEP
Inferred from Expression Pattern
more info
PubMed 
maternal process involved in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to prolactin IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
3-keto-steroid reductase
Names
17-beta-HSD 7
17-beta-hydroxysteroid dehydrogenase 7
PRAP
PRL receptor-associated protein
estradiol 17-beta-dehydrogenase 7
hydroxysteroid dehydrogenase 17 beta, type 7
NP_058931.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017235.3NP_058931.1  3-keto-steroid reductase

    See identical proteins and their annotated locations for NP_058931.1

    Status: VALIDATED

    Source sequence(s)
    AABR07021733, FM073997, FN803430
    UniProtKB/Swiss-Prot
    Q62904
    Conserved Domains (2) summary
    cd08941
    Location:2280
    3KS_SDR_c; 3-keto steroid reductase, classical (c) SDRs
    COG1028
    Location:1271
    FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

    Range
    88288116..88308011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250216.2XP_006250278.1  

    See identical proteins and their annotated locations for XP_006250278.1

    UniProtKB/Swiss-Prot
    Q62904
    UniProtKB/TrEMBL
    A0A0H2UHB1
    Related
    ENSRNOP00000003812, ENSRNOT00000003812
    Conserved Domains (2) summary
    cd08941
    Location:3281
    3KS_SDR_c; 3-keto steroid reductase, classical (c) SDRs
    COG1028
    Location:1272
    FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
  2. XM_006250215.2XP_006250277.1  

    See identical proteins and their annotated locations for XP_006250277.1

    UniProtKB/Swiss-Prot
    Q62904
    UniProtKB/TrEMBL
    A0A0H2UHB1
    Conserved Domains (2) summary
    cd08941
    Location:3281
    3KS_SDR_c; 3-keto steroid reductase, classical (c) SDRs
    COG1028
    Location:1272
    FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
  3. XM_006250217.2XP_006250279.1  

    See identical proteins and their annotated locations for XP_006250279.1

    UniProtKB/Swiss-Prot
    Q62904
    UniProtKB/TrEMBL
    A0A0H2UHB1
    Conserved Domains (2) summary
    cd08941
    Location:3281
    3KS_SDR_c; 3-keto steroid reductase, classical (c) SDRs
    COG1028
    Location:1272
    FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

Alternate Rn_Celera

Genomic

  1. AC_000081.1 Alternate Rn_Celera

    Range
    81835166..81852028 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)