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GSTZ1 glutathione S-transferase zeta 1 [ Homo sapiens (human) ]

Gene ID: 2954, updated on 12-May-2016
Official Symbol
GSTZ1provided by HGNC
Official Full Name
glutathione S-transferase zeta 1provided by HGNC
Primary source
HGNC:HGNC:4643
See related
Ensembl:ENSG00000100577 HPRD:04785; MIM:603758; Vega:OTTHUMG00000171551
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAI; MAAI; GSTZ1-1
Summary
This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme catalyzes the conversion of maleylacetoacetate to fumarylacetoacatate, which is one of the steps in the phenylalanine/tyrosine degradation pathway. Deficiency of a similar gene in mouse causes oxidative stress. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2015]
Orthologs
Location:
14q24.3
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (77320887..77331597)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (77787230..77797940)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene microRNA 1260a Neighboring gene neuroglobin Neighboring gene protein O-mannosyltransferase 2 Neighboring gene transmembrane p24 trafficking protein family member 8 Neighboring gene ATP binding cassette subfamily G member 2 (Junior blood group) pseudogene Neighboring gene sterile alpha motif domain containing 15

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of glutathione transferase zeta 1 (GSTZ1) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC2029

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione peroxidase activity TAS
Traceable Author Statement
more info
PubMed 
glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity TAS
Traceable Author Statement
more info
 
maleylacetoacetate isomerase activity EXP
Inferred from Experiment
more info
PubMed 
maleylacetoacetate isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
L-phenylalanine catabolic process IEA
Inferred from Electronic Annotation
more info
 
L-phenylalanine catabolic process TAS
Traceable Author Statement
more info
 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
glutathione derivative biosynthetic process TAS
Traceable Author Statement
more info
 
glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
tyrosine catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
maleylacetoacetate isomerase
Names
S-(hydroxyalkyl)glutathione lyase
glutathione S-alkyltransferase
glutathione S-aralkyltransferase
glutathione S-aryltransferase
glutathione transferase zeta 1
maleylacetone isomerase
NP_001504.2
NP_665877.1
NP_665878.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001312660.1NP_001299589.1  maleylacetoacetate isomerase isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which lacks a portion of the N-terminus (aa 1-55), and is shorter than isoform 1. This isoform lacks the glutathione-binding site, and hence, is unlikely to retain enzyme activity.
    Source sequence(s)
    AJ001838, AK315154, BC001453, BG772450
    Consensus CDS
    CCDS9860.1
    UniProtKB/Swiss-Prot
    O43708
    Conserved Domains (2) summary
    cd03191
    Location:38152
    GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
    cl00388
    Location:125
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  2. NM_145870.2NP_665877.1  maleylacetoacetate isomerase isoform 1

    See identical proteins and their annotated locations for NP_665877.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AJ001838, BC001453, BG772450
    Consensus CDS
    CCDS9858.1
    UniProtKB/Swiss-Prot
    O43708
    UniProtKB/TrEMBL
    A0A0C4DFM0
    Related
    ENSP00000216465, OTTHUMP00000246405, ENST00000216465, OTTHUMT00000414082
    Conserved Domains (3) summary
    cd03191
    Location:93207
    GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
    cd03042
    Location:680
    GST_N_Zeta; GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    TIGR01262
    Location:7211
    maiA; maleylacetoacetate isomerase
  3. NM_145871.2NP_665878.2  maleylacetoacetate isomerase isoform 2

    See identical proteins and their annotated locations for NP_665878.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AJ001838, BC001453, BG772450
    Consensus CDS
    CCDS9859.1
    UniProtKB/Swiss-Prot
    O43708
    UniProtKB/TrEMBL
    A0A0A0MR33
    Related
    ENSP00000314404, OTTHUMP00000246409, ENST00000349555, OTTHUMT00000414087
    Conserved Domains (3) summary
    cd03191
    Location:73165
    GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
    cd03042
    Location:672
    GST_N_Zeta; GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    TIGR01262
    Location:7169
    maiA; maleylacetoacetate isomerase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

    Range
    77320887..77331597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267559.2XP_005267616.1  

    See identical proteins and their annotated locations for XP_005267616.1

    UniProtKB/Swiss-Prot
    O43708
    Related
    ENSP00000354959, OTTHUMP00000246406, ENST00000361389, OTTHUMT00000414083
    Conserved Domains (2) summary
    cd03191
    Location:38152
    GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
    cl00388
    Location:125
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  2. XM_011536670.1XP_011534972.1  

    Conserved Domains (1) summary
    cd03191
    Location:54168
    GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
  3. XM_011536671.1XP_011534973.1  

    Related
    ENSP00000451976, OTTHUMP00000246413, ENST00000553586, OTTHUMT00000414096
    Conserved Domains (3) summary
    cd03191
    Location:74166
    GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
    cd03042
    Location:773
    GST_N_Zeta; GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    TIGR01262
    Location:8170
    maiA; maleylacetoacetate isomerase

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    77726689..77737398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001513.3: Suppressed sequence

    Description
    NM_001513.3: This RefSeq was removed because currently there is no support for the transcript.