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GSTT1 glutathione S-transferase theta 1 [ Homo sapiens (human) ]

Gene ID: 2952, updated on 30-Jun-2015
Official Symbol
GSTT1provided by HGNC
Official Full Name
glutathione S-transferase theta 1provided by HGNC
Primary source
HGNC:HGNC:4641
See related
HPRD:02700; MIM:600436
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. GSTT1 and GSTT2 share 55% amino acid sequence identity and both may play an important role in human carcinogenesis. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries. This GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes, which are also located on chromosome 22, have been identified. [provided by RefSeq, Jun 2014]
Annotation information
Annotation category: only annotated on alternate loci in reference assembly
Orthologs
See GSTT1 in MapViewer
Location:
22q11.23
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 22 (ALT_REF_LOCI_1) NT_187633.1 (270308..278486, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24376135..24384284, complement)

NT_187633.1Genomic Context describing neighboring genes Neighboring gene D-dopachrome tautomerase-like Neighboring gene eukaryotic translation initiation factor 4E binding protein 1 pseudogene 2 Neighboring gene MT-ND1 pseudogene 13 Neighboring gene glutathione S-transferase theta 1 pseudogene Neighboring gene glutathione S-transferase theta pseudogene 2 Neighboring gene glutathione S-transferase theta-1-like Neighboring gene calcineurin binding protein 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ18180, DKFZp762N226

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
glutathione derivative biosynthetic process TAS
Traceable Author Statement
more info
 
glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
glutathione S-transferase theta-1
Names
GST class-theta-1
glutathione transferase T1-1
NP_000844.2
NP_001280736.1
NP_001280737.1
NP_001280738.1
NP_001280739.1
NP_001280740.1
NP_001280741.1
NP_001280742.1
NP_001280743.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000853.3NP_000844.2  glutathione S-transferase theta-1 isoform a

    See identical proteins and their annotated locations for NP_000844.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AF435971, CA306446, CA487832
    UniProtKB/Swiss-Prot
    P30711
    Conserved Domains (3) summary
    cd03183
    Location:91216
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    COG0625
    Location:3212
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03050
    Location:378
    GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
  2. NM_001293807.1NP_001280736.1  glutathione S-transferase theta-1 isoform b

    See identical proteins and their annotated locations for NP_001280736.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional exon but lacks a different exon, which results in a frameshifted segment in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AF435971, BG536639, CA306446, CA487832, DA900601
    UniProtKB/Swiss-Prot
    P30711
    Conserved Domains (2) summary
    cd03183
    Location:103202
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    cl00388
    Location:337
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  3. NM_001293808.1NP_001280737.1  glutathione S-transferase theta-1 isoform c

    See identical proteins and their annotated locations for NP_001280737.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and uses an alternate splice site, resulting in an alternate 5' UTR and translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4, 5, 6 and 7 all encode isoform c.
    Source sequence(s)
    AJ874719, CA306446, CA487832
    UniProtKB/Swiss-Prot
    P30711
    UniProtKB/TrEMBL
    Q4GZS9
    Conserved Domains (1) summary
    cl02776
    Location:198
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
  4. NM_001293809.1NP_001280738.1  glutathione S-transferase theta-1 isoform c

    See identical proteins and their annotated locations for NP_001280738.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons, resulting in an alternate 5' UTR and translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4, 5, 6 and 7 all encode isoform c.
    Source sequence(s)
    CA306446, CA487832, CD701199
    UniProtKB/Swiss-Prot
    P30711
    Conserved Domains (1) summary
    cl02776
    Location:198
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
  5. NM_001293810.1NP_001280739.1  glutathione S-transferase theta-1 isoform c

    See identical proteins and their annotated locations for NP_001280739.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon, resulting in an alternate 5' UTR and translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4, 5, 6 and 7 all encode isoform c.
    Source sequence(s)
    CA306446, CA487832, CR456499
    UniProtKB/Swiss-Prot
    P30711
    Conserved Domains (1) summary
    cl02776
    Location:198
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
  6. NM_001293811.1NP_001280740.1  glutathione S-transferase theta-1 isoform c

    See identical proteins and their annotated locations for NP_001280740.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon, resulting in an alternate 5' UTR and translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4, 5, 6 and 7 all encode isoform c.
    Source sequence(s)
    BF343733, CA306446, CA487832
    UniProtKB/Swiss-Prot
    P30711
    Conserved Domains (1) summary
    cl02776
    Location:198
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
  7. NM_001293812.1NP_001280741.1  glutathione S-transferase theta-1 isoform c

    See identical proteins and their annotated locations for NP_001280741.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site, resulting in an alternate 5' UTR and translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4, 5, 6 and 7 all encode isoform c.
    Source sequence(s)
    BX401239, CA306446, CA487832
    UniProtKB/Swiss-Prot
    P30711
    Conserved Domains (1) summary
    cl02776
    Location:198
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
  8. NM_001293813.1NP_001280742.1  glutathione S-transferase theta-1 isoform d

    See identical proteins and their annotated locations for NP_001280742.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks two alternate exons, resulting in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AA298437, CA306446, CA487832
    Conserved Domains (1) summary
    cd03050
    Location:367
    GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
  9. NM_001293814.1NP_001280743.1  glutathione S-transferase theta-1 isoform e

    See identical proteins and their annotated locations for NP_001280743.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks three alternate exons, resulting in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AJ867758, CA306446, CA487832
    UniProtKB/TrEMBL
    Q4W251
    Conserved Domains (1) summary
    cl00388
    Location:337
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NT_187633.1 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    270308..278486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261587.2XP_005261644.1  

    Conserved Domains (3) summary
    cd03183
    Location:140265
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    COG0625
    Location:88261
    Gst; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03050
    Location:3127
    GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...