GSTP1 glutathione S-transferase pi 1 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: GSTP1provided by HGNC
Official Full Name: glutathione S-transferase pi 1provided by HGNC
Primary source: HGNC:4638
See related: Ensembl:ENSG00000084207; HPRD:00614; MIM:134660; Vega:OTTHUMG00000137430
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PI; DFN7; GST3; GSTP; FAEES3
Summary: Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 11q13

Sequence :: Chromosome: 11; NC_000011.9 (67351066..67354124)

See GSTP1 in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

the GSTT1 null genotype appears to be associated with a modest increase in the risk of NHL, whereas the GSTM1 and GSTP1 Ile105Val polymorphisms are unrelated to lymphoma risk.
Title: Role of polymorphisms of GSTM1, GSTT1 and GSTP1 Ile105Val in Hodgkin and non-Hodgkin lymphoma risk: a Human Genome Epidemiology (HuGE) review.
people with GSTM1 null genotype, with dual null genotype of GSTM1 and GSTT1, or with GSTT1 null genotype and GSTP1 A131G polymorphism are associated with high risks of PCa.
Title: Genetic polymorphisms of GSTM1, GSTT1, and GSTP1 with prostate cancer risk: a meta-analysis of 57 studies.
Variants of CBR3 and GSTP1 enzymes may be associated with changes in short-term functional cardiac parameters.
Title: The relationship between changes in functional cardiac parameters following anthracycline therapy and carbonyl reductase 3 and glutathione S transferase Pi polymorphisms.
GSTM1 and GSTP1, but not GSTT1 genetic polymorphisms are associated with increased risk of breast cancer in our population
Title: Association between polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and breast cancer risk in a sample Iranian population.
drug resistance in three strains of tumor cells is associated with significant increase in hGSTP1 and hGSTA4 gene expression, whereas increased hGSTK1 gene expression was detected only in resistant erythroleukemia and mammary adenocarcinoma cells.
Title: Expression of genes of glutathione transferase isoforms GSTP1-1, GSTA4-4, and GSTK1-1 in tumor cells during the formation of drug resistance to cisplatin.
No evidence of a significant association between the GSTP1 Ile105Val polymorphism and risk of head and neck cancers. [Meta-analysis]
Title: Association of GSTP1 Ile105Val polymorphism and risk of head and neck cancers: a meta-analysis of 28 case-control studies.
Among this indigenous South African children cohort, the GSTP1 genotype modified the effects of ambient exposures to PM(10) and SO(2) and lung function.
Title: GSTM1 and GSTP1 gene variants and the effect of air pollutants on lung function measures in South African children.
GSTP1 codon 105 polymorphism is associated with gastric cancer.
Title: Association between the GSTP1 codon 105 polymorphism and gastric cancer risk: an updated meta-analysis.
The GSTP1 105 G-allele is associated with permanent ototoxicity in pediatric medulloblastoma/PNET and strongly interacts with radiation dose.
Title: Glutathione S-transferase P1 single nucleotide polymorphism predicts permanent ototoxicity in children with medulloblastoma.
GSTM1 and GSTP1 polymorphisms are not associated with the risk of rheumatoid arthritis.
Title: The glutathione S-transferase M1 and P1 polymorphisms and rheumatoid arthritis: a meta-analysis.

Submit: New GeneRIF Correction See all (531)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
AY324387.1	NP_778224.1	HIST4H4	BIND	PubMed	HIST4H4 (H4) interacts with the GSTP1 promoter.
P09211	Q00597	FANCC	HPRD	PubMed
P09211	P09211	GSTP1	HPRD	PubMed
P09211	P45983	MAPK8	HPRD	PubMed
P09211	Q9NRX1	PNO1	HPRD	PubMed
P09211	P21246	PTN	HPRD	PubMed
P09211	Q6EEV6	SUMO4	HPRD	PubMed
P09211	P21980	TGM2	HPRD	PubMed
P09211	Q12933	TRAF2	HPRD	PubMed
BioGRID:109205	BioGRID:106574	ACTA2	BioGRID	PubMed	Co-fractionation
BioGRID:109205	BioGRID:107776	ATF2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109205	BioGRID:107452	CDK2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109205	BioGRID:116183	COPS5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109205	BioGRID:114031	CUL2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109205	BioGRID:114030	CUL3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109205	BioGRID:108473	FANCC	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:109205	BioGRID:108621	FN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109205	BioGRID:109205	GSTP1	BioGRID	PubMed	Co-crystal Structure
BioGRID:109205	BioGRID:114995	ISG15	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109205	BioGRID:109883	ITGA4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109205	BioGRID:115114	KIAA0101	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109205	BioGRID:110169	LIG4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109205	BioGRID:110378	MAP3K1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109205	BioGRID:111580	MAPK1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109205	BioGRID:111585	MAPK8	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109205	BioGRID:110438	MLH1	BioGRID	PubMed	Two-hybrid
BioGRID:109205	BioGRID:121232	PNO1	BioGRID	PubMed	Two-hybrid
BioGRID:109205	BioGRID:111731	PTN	BioGRID	PubMed	Two-hybrid
BioGRID:109205	BioGRID:121834	SCAF1	BioGRID	PubMed	Two-hybrid
BioGRID:109205	BioGRID:119602	SIRT7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109205	BioGRID:132223	SUMO4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109205	BioGRID:112910	TGM2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109205	BioGRID:113038	TRAF2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109205	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109205	BioGRID:115791	UBD	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109205	BioGRID:113255	VCAM1	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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4-hydroxy-2-nonenal detoxification, organism-specific biosystem (from BIOCYC)
4-hydroxy-2-nonenal detoxification, organism-specific biosystem
4-hydroxy-2-nonenal detoxification
Arachidonate Epoxygenase / Epoxide Hydrolase, organism-specific biosystem (from WikiPathways)
Arachidonate Epoxygenase / Epoxide Hydrolase, organism-specific biosystemThe cytochrome P450-dependent formation of polyunsaturated fatty acid epoxides is an important biochemical pathway creating mediators of inflammation and blood pressure regulation. Once formed these...
Biological oxidations, organism-specific biosystem (from REACTOME)
Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
Chemical carcinogenesis, organism-specific biosystem (from KEGG)
Chemical carcinogenesis, organism-specific biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
Chemical carcinogenesis, conserved biosystem (from KEGG)
Chemical carcinogenesis, conserved biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
Diurnally regulated genes with circadian orthologs, organism-specific biosystem (from WikiPathways)
Diurnally regulated genes with circadian orthologs, organism-specific biosystemHuman genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regu...
Drug metabolism - cytochrome P450, organism-specific biosystem (from KEGG)
Drug metabolism - cytochrome P450, organism-specific biosystem
Drug metabolism - cytochrome P450
Drug metabolism - cytochrome P450, conserved biosystem (from KEGG)
Drug metabolism - cytochrome P450, conserved biosystem
Drug metabolism - cytochrome P450
Glutathione conjugation, organism-specific biosystem (from REACTOME)
Glutathione conjugation, organism-specific biosystemGlutathione S-Transferases (GSTs; EC 2.5.1.18) are another major set of phase II conjugation enzymes. They can be found in the cytosol as well as being microsomal membrane-bound. Cytosolic GSTs are e...
Glutathione metabolism, organism-specific biosystem (from KEGG)
Glutathione metabolism, organism-specific biosystem
Glutathione metabolism
Glutathione metabolism, conserved biosystem (from KEGG)
Glutathione metabolism, conserved biosystem
Glutathione metabolism
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
Metabolism of xenobiotics by cytochrome P450, organism-specific biosystem (from KEGG)
Metabolism of xenobiotics by cytochrome P450, organism-specific biosystem
Metabolism of xenobiotics by cytochrome P450
Metabolism of xenobiotics by cytochrome P450, conserved biosystem (from KEGG)
Metabolism of xenobiotics by cytochrome P450, conserved biosystem
Metabolism of xenobiotics by cytochrome P450
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Phase II conjugation, organism-specific biosystem (from REACTOME)
Phase II conjugation, organism-specific biosystemPhase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involv...
Prostate cancer, organism-specific biosystem (from KEGG)
Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
Prostate cancer, conserved biosystem (from KEGG)
Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
glutathione-mediated detoxification I, organism-specific biosystem (from BIOCYC)
glutathione-mediated detoxification I, organism-specific biosystemPlease note: This is a general detoxification pathway, where the first step can be catalyzed by many different enzymes, collectively known as glutathione transferases, or GSTs. In the first reaction,...
metapathway biotransformation, organism-specific biosystem (from WikiPathways)
metapathway biotransformation, organism-specific biosystem
metapathway biotransformation

General gene information

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Markers

RH47100 (e-PCR)
- UniSTS:73781

GSTP1 (e-PCR)
- UniSTS:44904

G60258 (e-PCR)
- UniSTS:137364

GDB:270066 (e-PCR)
- UniSTS:156344

MARC_5389-5390:996690338:1 (e-PCR)
- UniSTS:269499

D11S4609 (e-PCR)
- UniSTS:11198

Homology

Homologs of the GSTP1 gene: The GSTP1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and C.elegans.
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
JUN kinase binding	ISS Inferred from Sequence or Structural Similarity more info
S-nitrosoglutathione binding	IDA Inferred from Direct Assay more info	PubMed
dinitrosyl-iron complex binding	IDA Inferred from Direct Assay more info	PubMed
glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
kinase regulator activity	ISS Inferred from Sequence or Structural Similarity more info
nitric oxide binding	NAS Non-traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cellular response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
central nervous system development	TAS Traceable Author Statement more info	PubMed
common myeloid progenitor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
negative regulation of I-kappaB kinase/NF-kappaB cascade	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of MAPK cascade	NAS Non-traceable Author Statement more info	PubMed
negative regulation of acute inflammatory response	NAS Non-traceable Author Statement more info	PubMed
negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
negative regulation of biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of fibroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of interleukin-1 beta production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of leukocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of monocyte chemotactic protein-1 production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of necrotic cell death	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of nitric-oxide synthase biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of stress-activated MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of tumor necrosis factor-mediated signaling pathway	IC Inferred by Curator more info	PubMed
nitric oxide storage	NAS Non-traceable Author Statement more info	PubMed
positive regulation of superoxide anion generation	ISS Inferred from Sequence or Structural Similarity more info
regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
regulation of stress-activated MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
response to reactive oxygen species	ISS Inferred from Sequence or Structural Similarity more info
small molecule metabolic process	TAS Traceable Author Statement more info
xenobiotic metabolic process	IDA Inferred from Direct Assay more info	PubMed
xenobiotic metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
TRAF2-GSTP1 complex	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	TAS Traceable Author Statement more info	PubMed
cytosol	TAS Traceable Author Statement more info
intracellular	IDA Inferred from Direct Assay more info	PubMed
mitochondrion	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutathione S-transferase P

Names: glutathione S-transferase P; GSTP1-1; GST class-pi; deafness, X-linked 7; fatty acid ethyl ester synthase III

NP_000843.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012075.1 RefSeqGene

Range

5001..8059

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000852.3 → NP_000843.1 glutathione S-transferase P

Status: REVIEWED

Source sequence(s)

BC010915, CA946272, X15480

Consensus CDS

CCDS41679.1

UniProtKB/Swiss-Prot

P09211

Related

ENSP00000381607, OTTHUMP00000174659, ENST00000398606, OTTHUMT00000268504

Conserved Domains (3) summary

cd03076
Location:3 – 76
Blast Score: 314

GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

PTZ00057
Location:8 – 196
Blast Score: 158

PTZ00057; glutathione s-transferase; Provisional

cd03210
Location:84 – 210
Blast Score: 597

GST_C_Pi; C-terminal, alpha helical domain of Class Pi Glutathione S-transferases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p10 Primary Assembly

Range

67351066..67354124

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

63680236..63683230

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018922.1 Alternate CHM1_1.0

Range

67270694..67273754

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01024027.1 (2129..4540)	None
genomic	ABBA01024028.1	None
genomic	AMYH01003747.1 (168029..171089)	None
genomic	AP001184.4 (100393..103230)	None
genomic	AY324387.1	AAP72967.1
genomic	CH471076.1	EAW74648.1
		EAW74649.1
		EAW74650.1
genomic	M24485.1	AAA56823.1
genomic	U12472.1	AAA64919.1
genomic	U21689.1	AAC13869.1
genomic	X08058.1	CAA30847.1
genomic	X08094.1	CAA30894.1
mRNA	AY579414.1	None
mRNA	BC010915.1	AAH10915.1
mRNA	BC044846.1	None
mRNA	BT019949.1	AAV38752.1
mRNA	BT019950.1	AAV38753.1
mRNA	CA946272.1	None
mRNA	CR450361.1	CAG29357.1
mRNA	GQ141553.1	ACT66687.1
mRNA	GQ141554.1	ACT66688.1
mRNA	U30897.1	AAC51280.1
mRNA	U62589.1	AAC51237.1
mRNA	X06547.1	CAA29794.1
mRNA	X15480.1	CAA33508.1
other-genetic	DQ892738.2	ABM83664.1
other-genetic	DQ895985.2	ABM86911.1