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GSTM4 glutathione S-transferase mu 4 [ Homo sapiens (human) ]

Gene ID: 2948, updated on 8-May-2016
Official Symbol
GSTM4provided by HGNC
Official Full Name
glutathione S-transferase mu 4provided by HGNC
Primary source
HGNC:HGNC:4636
See related
Ensembl:ENSG00000168765 HPRD:00706; MIM:138333; Vega:OTTHUMG00000011642
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GTM4; GSTM4-4
Summary
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified. [provided by RefSeq, Jul 2008]
Orthologs
Location:
1p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (109656076..109665501)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110198698..110208123)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha transducin 2 Neighboring gene adenosine monophosphate deaminase 2 Neighboring gene ribosomal protein L7 pseudogene 8 Neighboring gene glutathione S-transferase mu 2 (muscle) Neighboring gene glutathione S-transferase mu 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC9247, MGC131945

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
glutathione binding IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
glutathione derivative biosynthetic process TAS
Traceable Author Statement
more info
 
glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
nitrobenzene metabolic process IEA
Inferred from Electronic Annotation
more info
 
xenobiotic catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
Preferred Names
glutathione S-transferase Mu 4
Names
GST class-mu 4
GST-Mu2
GTS-Mu2
S-(hydroxyalkyl)glutathione lyase M4
glutathione S-alkyltransferase M4
glutathione S-aralkyltransferase M4
glutathione S-aryltransferase M4
glutathione S-transferase M4
testis tissue sperm-binding protein Li 60n
NP_000841.1
NP_671489.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000850.4NP_000841.1  glutathione S-transferase Mu 4 isoform 1

    See identical proteins and their annotated locations for NP_000841.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC000031, BC108729, BM673461, DA895954
    Consensus CDS
    CCDS807.1
    UniProtKB/Swiss-Prot
    Q03013
    Related
    ENSP00000358851, OTTHUMP00000013356, ENST00000369836, OTTHUMT00000032187
    Conserved Domains (3) summary
    cd03209
    Location:92211
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    COG0625
    Location:3189
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03075
    Location:384
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
  2. NM_147148.2NP_671489.1  glutathione S-transferase Mu 4 isoform 2

    See identical proteins and their annotated locations for NP_671489.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame exon in the 3' coding region and 3' UTR, compared to variant 1. It encodes a protein which has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC000031, BI791533, DA895954, M99422
    Consensus CDS
    CCDS806.1
    UniProtKB/Swiss-Prot
    Q03013
    Related
    ENSP00000316471, OTTHUMP00000013358, ENST00000326729, OTTHUMT00000032189
    Conserved Domains (3) summary
    cd03209
    Location:92189
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    COG0625
    Location:3189
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03075
    Location:384
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RNA

  1. NR_024538.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region resulting in a frameshift and early stop codon, compared to variant 1. The predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated decay (NMD).
    Source sequence(s)
    AC000031, BC015513, BM673461, DA895954, M99421
    Related
    ENST00000495742

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    109656076..109665501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541297.1XP_011539599.1  

    Conserved Domains (3) summary
    cd03209
    Location:92189
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    COG0625
    Location:3189
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03075
    Location:384
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
  2. XM_011541298.1XP_011539600.1  

    Conserved Domains (2) summary
    COG0625
    Location:1485
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cl02776
    Location:185
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    110313519..110322944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_147149.1: Suppressed sequence

    Description
    NM_147149.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.