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GSTM1 glutathione S-transferase mu 1 [ Homo sapiens (human) ]

Gene ID: 2944, updated on 29-May-2016
Official Symbol
GSTM1provided by HGNC
Official Full Name
glutathione S-transferase mu 1provided by HGNC
Primary source
HGNC:HGNC:4632
See related
Ensembl:ENSG00000134184 HPRD:00707; MIM:138350; Vega:OTTHUMG00000011635
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MU; H-B; GST1; GTH4; GTM1; MU-1; GSTM1-1; GSTM1a-1a; GSTM1b-1b
Summary
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
1p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (109687796..109693745)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110230418..110240828)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase mu 4 Neighboring gene glutathione S-transferase mu 2 (muscle) Neighboring gene glutathione S-transferase mu 5 Neighboring gene uncharacterized LOC105378894

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC26563

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
glutathione binding IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity TAS
Traceable Author Statement
more info
 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular detoxification of nitrogen compound IDA
Inferred from Direct Assay
more info
PubMed 
glutathione derivative biosynthetic process TAS
Traceable Author Statement
more info
 
glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
nitrobenzene metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
Preferred Names
glutathione S-transferase Mu 1
Names
GST HB subunit 4
GST class-mu 1
HB subunit 4
S-(hydroxyalkyl)glutathione lyase
glutathione S-alkyltransferase
glutathione S-aralkyltransferase
glutathione S-aryltransferase
glutathione S-transferase M1
NP_000552.2
NP_666533.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009246.1 RefSeqGene

    Range
    5001..10950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000561.3NP_000552.2  glutathione S-transferase Mu 1 isoform 1

    See identical proteins and their annotated locations for NP_000552.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC036805, DB459176, X08020
    Consensus CDS
    CCDS809.1
    UniProtKB/Swiss-Prot
    P09488
    UniProtKB/TrEMBL
    X5DR03
    Related
    ENSP00000311469, OTTHUMP00000013346, ENST00000309851, OTTHUMT00000032151
    Conserved Domains (3) summary
    cd03209
    Location:92212
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    COG0625
    Location:3189
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03075
    Location:384
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
  2. NM_146421.2NP_666533.1  glutathione S-transferase Mu 1 isoform 2

    See identical proteins and their annotated locations for NP_666533.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal in-frame exon in the coding region, compared to variant 1. The resulting protein (isoform 2) maintains the reading frame but is 37 amino acids shorter than isoform 1.
    Source sequence(s)
    BC024005, BC036805, DB459176
    Consensus CDS
    CCDS810.1
    UniProtKB/Swiss-Prot
    P09488
    UniProtKB/TrEMBL
    X5D932
    Related
    ENSP00000234981, OTTHUMP00000013347, ENST00000349334, OTTHUMT00000032152
    Conserved Domains (2) summary
    cd03075
    Location:384
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    cl02776
    Location:92175
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    109687796..109693745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270782.3XP_005270839.1  

    Conserved Domains (3) summary
    cd03209
    Location:58178
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    COG0625
    Location:9155
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cl00388
    Location:150
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  2. XM_005270783.3XP_005270840.1  

    Conserved Domains (2) summary
    cd03209
    Location:1108
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    COG0625
    Location:1485
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]