Acta1 actin, alpha 1, skeletal muscle [Rattus norvegicus] - Gene

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Summary

Official Symbol: Acta1provided by RGD
Official Full Name: actin, alpha 1, skeletal muscleprovided by RGD
Primary source: RGD:2025
See related: Ensembl:ENSRNOG00000017786
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary: may act as a structural component of the cytoskeleton; may play a role in muscle function [RGD, Feb 2006]

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Genomic context

Location :: 19q12

Sequence :: Chromosome: 19; NC_005118.2 (54081496..54084508, complement)

See Acta1 in MapViewer

Chromosome 19 - NC_005118.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The effects of reactive oxygen species on tryptophan residues in alpha skeletal actin and troponin I, was investigated.
Title: Quantitative evaluation of tryptophan oxidation in actin and troponin I from skeletal muscles using a rat model of acute oxidative stress.
SHP2 negatively regulates alpha-SKA expression via RhoA inactivation and suggest that SHP2 implicates ERK5 in cardiomyocyte elongation downstream of gp130.
Title: SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene.
actin cytoskeletal mechanics are an essential feature of the glucose transport process in intact skeletal muscle
Title: Disruption of cortical actin in skeletal muscle demonstrates an essential role of the cytoskeleton in glucose transporter 4 translocation in insulin-sensitive tissues.

Submit: New GeneRIF Correction

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:248084	BioGRID:270726	Sumo3		BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cell growth	IEP Inferred from Expression Pattern more info	PubMed
response to extracellular stimulus	IEP Inferred from Expression Pattern more info	PubMed
response to lithium ion	IEP Inferred from Expression Pattern more info	PubMed
response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
response to steroid hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
skeletal muscle fiber adaptation	IEP Inferred from Expression Pattern more info	PubMed
skeletal muscle fiber development	ISO Inferred from Sequence Orthology more info
skeletal muscle fiber development	ISS Inferred from Sequence or Structural Similarity more info
skeletal muscle thin filament assembly	ISO Inferred from Sequence Orthology more info
skeletal muscle thin filament assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
actin cytoskeleton	ISO Inferred from Sequence Orthology more info
actin filament	ISO Inferred from Sequence Orthology more info
actin filament	ISS Inferred from Sequence or Structural Similarity more info
cellular_component	ND No biological Data available more info
cytoplasm	IEA Inferred from Electronic Annotation more info
sarcomere	ISO Inferred from Sequence Orthology more info
stress fiber	ISO Inferred from Sequence Orthology more info
stress fiber	ISS Inferred from Sequence or Structural Similarity more info
striated muscle thin filament	ISO Inferred from Sequence Orthology more info
striated muscle thin filament	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Preferred Names: actin, alpha skeletal muscle

Names: actin, alpha skeletal muscle; actin alpha 1; alpha-actin-1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019212.2 → NP_062085.1 actin, alpha skeletal muscle

Status: PROVISIONAL

Source sequence(s)

BC061974

UniProtKB/Swiss-Prot

P68136

Related

ENSRNOP00000024084, ENSRNOT00000024084

Conserved Domains (2) summary

cd00012
Location:9 – 375
Blast Score: 1495

ACTIN; Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one ...

pfam00022
Location:5 – 377
Blast Score: 1723

Actin; Actin