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GSPT1 G1 to S phase transition 1 [ Homo sapiens (human) ]

Gene ID: 2935, updated on 15-May-2016
Official Symbol
GSPT1provided by HGNC
Official Full Name
G1 to S phase transition 1provided by HGNC
Primary source
HGNC:HGNC:4621
See related
Ensembl:ENSG00000103342 HPRD:00753; MIM:139259; Vega:OTTHUMG00000172956
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GST1; ETF3A; eRF3a; 551G9.2
Orthologs
Location:
16p13.1
Exon count:
16
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (11868128..11916662, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (11961985..12010519, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene breast cancer anti-estrogen resistance 4 (non-protein coding) Neighboring gene ribosomal L1 domain containing 1 Neighboring gene uncharacterized LOC105371084 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 1 Neighboring gene nuclear pore complex interacting protein family member A1 pseudogene Neighboring gene tumor necrosis factor receptor superfamily member 17

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
    mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
  • mRNA surveillance pathway, conserved biosystem (from KEGG)
    mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ38048, FLJ39067

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity TAS
Traceable Author Statement
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation release factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
cytoplasmic translational termination IBA
Inferred from Biological aspect of Ancestor
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
PubMed 
protein methylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
intracellular NAS
Non-traceable Author Statement
more info
PubMed 
translation release factor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
eukaryotic peptide chain release factor GTP-binding subunit ERF3A
Names
G1 to S phase transition protein 1 homolog
eukaryotic peptide chain release factor subunit 3a

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130006.1NP_001123478.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 2

    See identical proteins and their annotated locations for NP_001123478.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in an internal exon, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AC007216, AU132091, BC008391, BC009503, BM666324, DC384910
    Consensus CDS
    CCDS45413.1
    UniProtKB/Swiss-Prot
    P15170
    Related
    ENSP00000408399, OTTHUMP00000249814, ENST00000439887, OTTHUMT00000421511
    Conserved Domains (5) summary
    cd01883
    Location:213429
    EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
    COG5256
    Location:209633
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    cd04089
    Location:438519
    eRF3_II; eRF3_II: domain II of the eukaryotic class II release factor (eRF3). In eukaryotes, translation termination is mediated by two interacting release factors, eRF1 and eRF3, which act as class I and II factors, respectively. eRF1 functions as an omnipotent ...
    pfam07145
    Location:6481
    PAM2; Ataxin-2 C-terminal region
    cd03704
    Location:525631
    eRF3c_III; C-terminal domain of eRF3
  2. NM_001130007.1NP_001123479.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 3

    See identical proteins and their annotated locations for NP_001123479.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. The resulting isoform (3) is shorter at the N-terminal, compared to isoform 1.
    Source sequence(s)
    AC007216, AK315267, BM666324, BT006722
    Consensus CDS
    CCDS45414.1
    UniProtKB/Swiss-Prot
    P15170
    UniProtKB/TrEMBL
    B2RCT6, Q7KZX8
    Related
    ENSP00000399539, OTTHUMP00000249817, ENST00000420576, OTTHUMT00000421514
    Conserved Domains (4) summary
    cd01883
    Location:76292
    EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
    COG5256
    Location:72496
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    cd04089
    Location:301382
    eRF3_II; eRF3_II: domain II of the eukaryotic class II release factor (eRF3). In eukaryotes, translation termination is mediated by two interacting release factors, eRF1 and eRF3, which act as class I and II factors, respectively. eRF1 functions as an omnipotent ...
    cd03704
    Location:388494
    eRF3c_III; C-terminal domain of eRF3
  3. NM_002094.3NP_002085.2  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 1

    See identical proteins and their annotated locations for NP_002085.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC007216, AU132091, BC008391, BM666324, BT006722, DC384910
    Consensus CDS
    CCDS45412.1
    UniProtKB/TrEMBL
    Q7KZX8
    Related
    ENSP00000398131, OTTHUMP00000249813, ENST00000434724, OTTHUMT00000421510
    Conserved Domains (5) summary
    cd01883
    Location:214430
    EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
    COG5256
    Location:210634
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    cd04089
    Location:439520
    eRF3_II; eRF3_II: domain II of the eukaryotic class II release factor (eRF3). In eukaryotes, translation termination is mediated by two interacting release factors, eRF1 and eRF3, which act as class I and II factors, respectively. eRF1 functions as an omnipotent ...
    pfam07145
    Location:6481
    PAM2; Ataxin-2 C-terminal region
    cd03704
    Location:526632
    eRF3c_III; C-terminal domain of eRF3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    11868128..11916662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    11962002..12010568 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)