Stmn1 stathmin 1 [Rattus norvegicus] - Gene

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Summary

Official Symbol: Stmn1provided by RGD
Official Full Name: stathmin 1provided by RGD
Primary source: RGD:2992
See related: Ensembl:ENSRNOG00000016810
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as: SMN; OP18; PP17; PP19; PR22; Lap18; prosolin; MGC72884
Summary: may promote microtubule depolymerization; may act as a signaling relay phosphoprotein for second messenger signaling pathways involved in cell proliferation and differentiation [RGD, Feb 2006]
Annotation information: Annotation category: partial on reference assembly

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Genomic context

Location :: 5q36

Sequence :: Chromosome: 5; NC_005104.2 (153226420..153232084)

See Stmn1 in MapViewer

Chromosome 5 - NC_005104.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

role of stathmin 1 in FcRI-mediated activation of cells of mast cell lineage and might shed light on the diverse response of these cells to IgE or IgE plus antigen.
Title: A novel insight to the functional role of Stathmin 1 in IgE-mediated activation of RBL-2H3 cells.
Stathmin 1 is involved in the neuroprotective effect of pituitary adenylate cyclase-activating polypeptide (PACAP) in PC12 cells subjected to serum starvation.
Title: Involvement of stathmin 1 in the neurotrophic effects of PACAP in PC12 cells.
Stathmin expression increases in the uterus when stimulated by embryo implantation and decidualization and may play a role in the early stages of pregnancy.
Title: Enhanced expression of uterine stathmin during the process of implantation and decidualization in rats.
Sustained stathmin levels in differentiating oligodendrocytes, because of overexpression, resulted in enhanced apoptotic susceptibility.
Title: Expression of stathmin, a developmentally controlled cytoskeleton-regulating molecule, in demyelinating disorders.
role for stathmin in the migration of newborn neurons in the adult brain
Title: Proteomic and immunochemical characterization of a role for stathmin in adult neurogenesis.
Identification of cJun-responsive genes in Rat-1a cells using multiple techniques: increased expression of this protein is necessary for cJun-mediated anchorage-independent growth.
Title: Identification of cJun-responsive genes in Rat-1a cells using multiple techniques: increased expression of stathmin is necessary for cJun-mediated anchorage-independent growth.
Given that the microtubule-destabilizing activity of Op18/stathmin is regulated by its phosphorylation, the ASK1-p38 cascade may regulate microtubule dynamics through Op18/stathmin.
Title: Identification of Op18/stathmin as a potential target of ASK1-p38 MAP kinase cascade.

Submit: New GeneRIF Correction

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Function	Evidence Code	Pubs
tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
axonogenesis	IEA Inferred from Electronic Annotation more info
axonogenesis	ISO Inferred from Sequence Orthology more info
brain development	IEP Inferred from Expression Pattern more info	PubMed
cell differentiation	IEA Inferred from Electronic Annotation more info
intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
microtubule depolymerization	ISO Inferred from Sequence Orthology more info
microtubule depolymerization	TAS Traceable Author Statement more info	PubMed
mitotic spindle organization	ISO Inferred from Sequence Orthology more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
negative regulation of microtubule polymerization	IEA Inferred from Electronic Annotation more info
negative regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
nervous system development	IEA Inferred from Electronic Annotation more info
positive regulation of cellular component movement	IEA Inferred from Electronic Annotation more info
positive regulation of cellular component movement	ISO Inferred from Sequence Orthology more info
response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoplasm	ISO Inferred from Sequence Orthology more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
cytosol	IEA Inferred from Electronic Annotation more info
cytosol	ISO Inferred from Sequence Orthology more info
intracellular	ISO Inferred from Sequence Orthology more info
intracellular	TAS Traceable Author Statement more info	PubMed
membrane fraction	IEA Inferred from Electronic Annotation more info
membrane fraction	ISO Inferred from Sequence Orthology more info
microtubule	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: stathmin

Names: stathmin; metablastin; oncoprotein 18; phosphoprotein p19; leukemia-associated phosphoprotein p18; leukemia-associated cytosolic phosphoprotein stathmin

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017166.1 → NP_058862.1 stathmin

Status: PROVISIONAL

Source sequence(s)

J04979

UniProtKB/Swiss-Prot

P13668

Related

ENSRNOP00000022574, ENSRNOT00000022574

Conserved Domains (1) summary

pfam00836
Location:4 – 143
Blast Score: 344

Stathmin; Stathmin family

RefSeqs of Annotated Genomes: Build 4.2

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly (based on RGSC_v3.4)

Genomic

NC_005104.2 Reference assembly (based on RGSC_v3.4)

Range

153226420..153232084

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate assembly (Rn_Celera)

Genomic

AC_000073.1 Alternate assembly (Rn_Celera)

Range

145096588..145102252

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	CH473968.1	EDL80724.1
		EDL80725.1
		EDL80727.1
mRNA	BC062234.1	AAH62234.1
mRNA	J04979.1	AAA42184.1
mRNA	M27876.1	AAA81570.1
mRNA	X94914.1	CAA64400.1