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Klk6 kallikrein related-peptidase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29245, updated on 5-Mar-2024

Summary

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Official Symbol
Klk6provided by RGD
Official Full Name
kallikrein related-peptidase 6provided by RGD
Primary source
RGD:3419
See related
Ensembl:ENSRNOG00000031927 AllianceGenome:RGD:3419
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Klni; Prss9
Summary
Enables peptidase activity. Involved in regulation of neuron projection development. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in secretory granule. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; demyelinating disease; and multiple system atrophy. Orthologous to human KLK6 (kallikrein related peptidase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 107.5), Lung (RPKM 21.1) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
1q22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (103415411..103422682)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (94278863..94286136)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (99762195..99769486)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene kallikrein related-peptidase 8 Neighboring gene kallikrein-related peptidase 7 Neighboring gene kallikrein related-peptidase 5 Neighboring gene uncharacterized LOC134484892

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ovarian cancer specific kallikrein profile in effusions. Shih IeM, et al. Gynecol Oncol, 2007 May. PMID 17303231
  2. Dynamic role of kallikrein 6 in traumatic spinal cord injury. Scarisbrick IA, et al. Eur J Neurosci, 2006 Sep. PMID 16987227
  3. Prognostic implications of the immunohistochemical expression of human kallikreins 5, 6, 10 and 11 in renal cell carcinoma. Petraki CD, et al. Tumour Biol, 2006. PMID 16340244
  4. Enzymatic properties of rat myelencephalon-specific protease. Blaber SI, et al. Biochemistry, 2002 Jan 29. PMID 11802715
  5. Nervous system-specific expression of a novel serine protease: regulation in the adult rat spinal cord by excitotoxic injury. Scarisbrick IA, et al. J Neurosci, 1997 Nov 1. PMID 9334391, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exercise improves the body function and protects the neuronal injury in Parkinson's disease rats by activating calpain 1 and kallikrein 6.
    Title: Exercise improves the body function and protects the neuronal injury in Parkinson's disease rats by activating calpain 1 and kallikrein 6.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of neuron projection development IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cornified envelope ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kallikrein-6
Names
kallikrein 6 (neurosin)
kallikrein 6 (neurosin, zyme)
kallikrein i
protease serine 9 (neurosin)
protease, serine, 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019175.1 → NP_062048.1  kallikrein-6 precursor

    See identical proteins and their annotated locations for NP_062048.1

    Status: PROVISIONAL

    Source sequence(s)
    AF016269
    UniProtKB/TrEMBL
    A0A1R3UDT9, F7F6H9, O54854
    Related
    ENSRNOP00000060676.1, ENSRNOT00000065876.3
    Conserved Domains (2) summary
    smart00020
    Location:28 → 244
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:29 → 247
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    103415411..103422682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228982.5 → XP_006229044.1  kallikrein-6 isoform X1

    See identical proteins and their annotated locations for XP_006229044.1

    UniProtKB/TrEMBL
    A0A1R3UDT9, F7F6H9, O54854
    Conserved Domains (2) summary
    smart00020
    Location:28 → 244
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:29 → 247
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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